Ventricular Systolic Function Flashcards
LV systolic function
Ventricles pump blood into systemic and pulmonary circulation
Ensure adequate perfusion to the body
What is systolic dysfunction
Inability to contract
In systolic dysfunction what happens
Decreases in SV/EF
Increase in preload (LVEDP)
?CHF
Diastole is
Ventricular distension/ relaxation
What is starling’s law
As filling occurs, stretch in muscle develops tension/strength for contraction, generate negative pressure gradient to ensure venous return, coronary arteries fill during this time
Ventricular systole is produced by and what is it followed by
Depolarization of the ventricles
Followed by mechanical contraction
What produces increased pressure within LV and RV
Ventricular myocardium contraction
What are the phases of systole
Isovolumic contraction
Ventricular ejection
What is isovolumic contraction
All valves closed, ventricular pressure is building up
What happens in the ventricular ejection phase
Atrio-ventricular valves closed
Semilunar valves open caused by pressure gradient between LV and aorta
Ejection occurs until ventricular pressure equalizes within the great vessels
What is the sequence of systole
Myocardial depolarization —>contraction—>ejection
Electrical stimulation of the heart that results in a contraction of the myocardium
Pressure increases, causing a reduction of the internal volume of the chamber
What is the timing of systole
IVCT- onset of QRS complex
Ejection
When does ejection of systole start
AV opens
When does systolic ejection end
When the AV closes
What are the pressures of the AO
Systolic: 120mmHg
Diastolic: 70mmHg
Mean: 85mmHg
What are the pressures in the PA
Systolic: 25mmHg
Diastolic: 10mmHg
Mean: 16mmHg
What is the mean pressure of the LA
10mmHg
What is the mean pressure of the RA
4mmHg
What are the pressures of the RV
Systolic: 25mmHg
Diastolic: 4mmHg
What are the pressures of the LV
Systolic: 120mmHg
Diastolic: 10mmHg
After depolarization of the ventricular muscle what starts to contract
LV/RV
What does contraction increase
Intra-cavitary pressure
Pressure rises until it exceeds what
AO/PA pressure which opens the AV/PV and blood is ejected
After ejection what happens
LV/RV pressure falls below the AO and PA, which closes the AV and PV
The pressure keeps falling during relaxation until what
MV and TV open
Filling sees a large change in ___ with only a slight ____ in ______.
Volume
Increase
Pressure
The LV has what kind of pressure volume loop
Rectangular
The RV has what kind of pressure volume loop
Triangular
Why is the RV different from the LV pressure volume loop
Lower pressure are on the right side
Lowers impedance of the pulmonary vascular bed
Even after the peak pressure is reached, flow continues to enter where and from where
The PA from the RV
Determinates of SV
Preload
Afterload
Contractility
Preload is
Muscle length or stretch at end-diastole
Since the intact heart cannot be measures we estimate preload by using
LVEDV
PVEDP
LA pressure
Changes in preload alter what
The end-diastolic volume
Altering the end-diastolic volume caused by the change in preload increases the what
Amount of stretch
Afterload is
The tension that the LV must overcome before fiber shortening and contraction
What affects afterload
Changes in ventricular volume, wall thickness or vascular resistance
Is the LV or the RV more sensitive to afterload
RV
What is contractility
Inherent strength of the cardiac muscle and ablility to shorten as it contracts
Changing any one the three determinants of stroke volume will do what
Affect the other two
What are the factors the increase stroke volume
Increased preload
Decreased afterload
Increased inotropy
What are the factors that decrease stroke volume
Decrease preload
Increase afterload
Decrease inotropy
Fractional shortening and ejection fraction are what kind of systolic measurement
Quantitative
What are the volumetric assessments of LV systolic function
Simpson’s EF Area length method stroke volume -> cardiac output, cardiac index Dp/Dt Tissue doppler MPI global strain
What are the qualitative LV systolic function measurements
Visual kinetic analysis (global EF estimation)
Segmental wall motion analysis
What are the 4 different types of segmental wall motion analysis
Normal
Hypokinetic
Akinetic
Dyskinetic
What is the normal value for a parasternal EF
55%
What is the normal value for fractional shortening
> 25%
What is the normal Simpson’s EF for males
52-72
What is the normal Simpson’s EF for females
54-74
% of change in the minor axis dimension has a correlation to what
EF
When to measure end diastolic
Isovolumic contraction time
- onset of the QRS complex
- frame after MV closure
- frame where LV diameter/dimension is largest
When to measure end systole
Isovolumic relaxation time
- the frame preceding MV opening
- when the LV is the smallest
- near the end of the T wave
When peak downward displacement if the septum is abnormal what should be used for timing
The peak upward displacement if the posterior wall
Increasing what can help the linear EF with abnormal IVS
Frame rate
Simpson’s biplane is also called the
Method of disks
What does the Simpson’s biplane method rely on
Endocardium tracing in 2 apical views
What are the 2 apical views that the Simpson’s biplane uses
A4C
A2C
The length of the LV should extend from where to where
The middle of the MV annulus to the true LV apex
If the true apex cannot be seen well, what should not be done
Simpsons
Ensure that the LV central axis in diastole or length does not differ between the A4C and A2C views by more than what
10%
What is derived from the volumetric assessment
Stroke volume
Ejection fraction
What is the cardiac output equation
CO= SV x HR
What is the equation for the volumetric assessment
SV = EDV-ESV
What can be performed when the endocardial definition is suboptimal from the apical images but good from parasternal
Area-length method
How is the area-length method performed
Trace the LV chamber at the pap muscle level then measure the LV length in the A4C view from the MV annulus to the apex
What does the SV calculation assume about the LVOT
That it is circular
What is also assumed in the SV calculation
Laminar flow
Most indices of cardiac performance are influenced by
Loading conditions, like SV CO CI
When is the Dp/Dt measured
During the pre-ejection phase of the cardiac cycle
Dp/Dt is less influenced by what
Loading conditions
Dp is the
Change in pressure
Dt is the
Change in time it takes to reach that pressure
What are the points that are Usually chosen for Dp/Dt
1 m/s and 3m/s
Dp/Dt uses which principle
Bernoulli
What is the pressure at 1 m/s in the Bernoulli equation
4mmHg
What is the pressure at 3 m/s in the Bernoulli equation
36mmHg
What is the difference between the two pressures (1 m/s and 3 m/s)
32mmHg
Dp/Dt measures how much time it takes for what
The LV pressure to rise by 32mmHg
What are the limitations of Dp/Dt
Valve click artifact (from prosthetic valves)
Eccentric MR jets (difficult to pick up CW)
Poor alignment to the MR jets
Non-compliant LA
What is the normal value for Dp/Dt
<27 msec
Tissue doppler measures the speed that the
LV muscle contracts in the longitudinal plane
What is the normal value for tissue doppler
> 9.0 cm/s
Tissue doppler is a good measurement of
Systolic function
Muscle tissues in the LV are arranged
Longitudinally
Radially
Circumferentially
What is the S prime influenced by
Tethering and translational motion of the heart
What is tethering
When a hypokinetic or akinetic segment is adjacent to a normal segment and gets dragged along by its motion
What velocities progressively decrease form base to apex in the normal heart
S prime
S prime will not be accurate when there is varying degrees of
Segmental systolic dysfunction, as it will not include those abnormal segments
S prime will be fairly accurate when
Wall motion is normal or globally down
S prime measures what
The velocity of the tissue in one of the basal segments from the apical view
Therefore what can the s prime only truly reflect
The performance of that segment
When is the index of myocardial performance used in cases with
Dilated cardiomyopathy Cardiac amyloidosis Pulmonary hypertension RV infarction RV dysplasia
MPI provides information about both
Systolic and diastolic function
IMP is a ratio between
(ICT+IRT)/ET
May disease states include some degree of
Systolic and diastolic dysfunction
In a diseased heart, what happens to ejection time and isovolumic times
ET shortens, isovolumic times increase
What is the normal LV for the MPI conventional doppler method
<0.44
What are the normal measurements for the TDI method
LV: <0.6
RV: <0.55
The normal RV in the A4C view should be ___ than ___ the size of the LV
Less
2/3
Should the RV or the LV dominate the apex
LV
Mild dilation of the RV is when the
RV >2/3 of the LV but RV cavity is still smaller than LV.
The RV apex more basal than the LV apex is what
Normal
Moderate dilation of the RV
When the RV and the LV are equal size and share the apex
Severe dilatation of the RV is when
RV>LV size and RV occupies the apex
Walls MUST be seen in how many views to be scored qualitatively
2 or more