Ventricular Systolic Function Flashcards
LV systolic function
Ventricles pump blood into systemic and pulmonary circulation
Ensure adequate perfusion to the body
What is systolic dysfunction
Inability to contract
In systolic dysfunction what happens
Decreases in SV/EF
Increase in preload (LVEDP)
?CHF
Diastole is
Ventricular distension/ relaxation
What is starling’s law
As filling occurs, stretch in muscle develops tension/strength for contraction, generate negative pressure gradient to ensure venous return, coronary arteries fill during this time
Ventricular systole is produced by and what is it followed by
Depolarization of the ventricles
Followed by mechanical contraction
What produces increased pressure within LV and RV
Ventricular myocardium contraction
What are the phases of systole
Isovolumic contraction
Ventricular ejection
What is isovolumic contraction
All valves closed, ventricular pressure is building up
What happens in the ventricular ejection phase
Atrio-ventricular valves closed
Semilunar valves open caused by pressure gradient between LV and aorta
Ejection occurs until ventricular pressure equalizes within the great vessels
What is the sequence of systole
Myocardial depolarization —>contraction—>ejection
Electrical stimulation of the heart that results in a contraction of the myocardium
Pressure increases, causing a reduction of the internal volume of the chamber
What is the timing of systole
IVCT- onset of QRS complex
Ejection
When does ejection of systole start
AV opens
When does systolic ejection end
When the AV closes
What are the pressures of the AO
Systolic: 120mmHg
Diastolic: 70mmHg
Mean: 85mmHg
What are the pressures in the PA
Systolic: 25mmHg
Diastolic: 10mmHg
Mean: 16mmHg
What is the mean pressure of the LA
10mmHg
What is the mean pressure of the RA
4mmHg
What are the pressures of the RV
Systolic: 25mmHg
Diastolic: 4mmHg
What are the pressures of the LV
Systolic: 120mmHg
Diastolic: 10mmHg
After depolarization of the ventricular muscle what starts to contract
LV/RV
What does contraction increase
Intra-cavitary pressure
Pressure rises until it exceeds what
AO/PA pressure which opens the AV/PV and blood is ejected
After ejection what happens
LV/RV pressure falls below the AO and PA, which closes the AV and PV
The pressure keeps falling during relaxation until what
MV and TV open
Filling sees a large change in ___ with only a slight ____ in ______.
Volume
Increase
Pressure
The LV has what kind of pressure volume loop
Rectangular
The RV has what kind of pressure volume loop
Triangular
Why is the RV different from the LV pressure volume loop
Lower pressure are on the right side
Lowers impedance of the pulmonary vascular bed
Even after the peak pressure is reached, flow continues to enter where and from where
The PA from the RV
Determinates of SV
Preload
Afterload
Contractility
Preload is
Muscle length or stretch at end-diastole
Since the intact heart cannot be measures we estimate preload by using
LVEDV
PVEDP
LA pressure
Changes in preload alter what
The end-diastolic volume
Altering the end-diastolic volume caused by the change in preload increases the what
Amount of stretch
Afterload is
The tension that the LV must overcome before fiber shortening and contraction
What affects afterload
Changes in ventricular volume, wall thickness or vascular resistance
Is the LV or the RV more sensitive to afterload
RV
What is contractility
Inherent strength of the cardiac muscle and ablility to shorten as it contracts
Changing any one the three determinants of stroke volume will do what
Affect the other two
What are the factors the increase stroke volume
Increased preload
Decreased afterload
Increased inotropy
What are the factors that decrease stroke volume
Decrease preload
Increase afterload
Decrease inotropy