Ventilation Flashcards
Why do we use PCO2 to assess ventilation?
Because CO2 is much (20x) more soluble in blood than O2, so measuring CO2 is usually a close approximation of ventilatory efficacy.
What is the calculation for minute ventilation?
Minute ventilation = tidal volume x resp rate
What is the difference between hypoxia and hypoxemia?
- Hypoxemia - decreased O2 dissolved in the blood (plasma)
- Hypoxia - decreased O2 delivery to the tissues
Why do we use PaO2 as the parameter to measure gas exchange and not PCO2?
because issues with oxygen delivery will occur first if gas exchange is not performed adequately
Intrapulmonary and intrapleural pressure do what upon expiration vs. inspiration?
- Expiration: both increase
- Inspiration: both decrease (due to contraction of diaphragm and intercostal muscles)
What are the 5 causes of hypoxemia? (Ranked from most to least common)
- Ventilation-perfusion mismatch
- Low FiO2
- Hypoventilation
- Anatomic shunts
- Diffusion barriers
What is the most common cause of hypoxemia in anesthetized patients?
V-Q mismatch
What would cause a high V/Q ratio?
If blood flow is decreased; your PaO2 will equal the FiO2 and PaCO2 will be 0 mmHg
- This is called dead space ventilation
What would cause a low V/Q ratio?
Ventilation is decreased, typically by atelectasis; PaO2 = PvO2 and PaCO2 = PvCO2
- Physiologic shunt - allow deoxygenated blood to enter systemic circulation and is effectively a R—> L shunt
T or F: oxygen insufflation can slow the adverse effects of hypoventilation/apnea
true
How do anatomic shunts (such as a reverse PDA) differ from physiologic shunts?
Physiologic shunts return to normal once patient recovers from anesthesia, anatomic shunts will not resolve without anatomic correction
What might be a cause for diffusion impairment?
pulmonary fibrosis, due to the thickening of the blood-gas barrier
What are the 4 types of hypoxia?
- Circulatory
- Anemic
- Cytotoxic/histotoxic
- Hypoxemic
Describe circulatory hypoxia
Due to cardiac arrest or extremely low cardiac output
- Tissue oxygen delivery cannot occur b/c the cardiac pump/vascular system is not functional/severely compromised
Describe anemic hypoxia
tissue oxygen delivery is insufficient b/c of low Hb content (particularly oxyhemoglobin)