Venous Thromboembolism Low molecular weight Heparin (LMWH) - recorded lecture

Question 1

Pharmacokinetic characteristic advantages of LMWH compared to UFH

Answer 1

• reduced protein binding
• predictable dose response
• Longer plasma half-life
• smaller molecule
• less effect of platelets and endothelium

Question 2

Clinical advantages of LMWH compared to UFH

Answer 2

• good bioavailability and predictable dose response
• resistance not encountered
• Fixed or weight-based dosing possible
• monitoring not required
• once or twice daily dosing
• reduced incidence of HIT and possibly, bleeding

Question 3

when to consider Monitoring for LMWH

Answer 3

Monitor anti Xa levels
Consider for children, severe kidney failure, obesity, long courses, pregnancy