Diabetes Medications

Question 1

Lispro (Humalog)

Answer 1

• Rapid onset and short action
• reversing positions of P28 and K29 on B chain
• makes insulin onset much faster

Question 2

Aspart (novolog)

Answer 2

• Rapid onset and short action
• Changing the P28 to aspartate

Question 3

Glulisine (apidra)

Answer 3

• Rapid onset and short action
• Asn 3 and Lys 29 are switched to Lys and Glu

Question 4

Glargine (Lantus)

Answer 4

-Slow onset and long action
Asn 21 of A chain is changed to Gly

Question 5

Detemir (Levemir)

Answer 5

-Slow onset and long action
- Thr 30 is deleted and Lys 29

Question 6

Degludec (tresiba)

Answer 6

-Slow onset and long action

Question 7

NPH insulin (N)

Answer 7

Slow absorption and long duration of action
- Insulin bound to protamine which when injected protamine is broken down by tissue protease and insulin is slowly released