Venketaraman- Hematopoiesis

Question 1

at what point of development are pluripotent stem cells first seen in the bone moarrow?

Answer 1

7th month. (prior in months 3-7 they are in the liver/spleen)

Question 2

what do myeloid cells ultimately give rise too?

Answer 2

erythrocytes, neutrophils, basophils, eosinophils, monocytes and platelets

Question 3

erythropoiesis is hormonally controlled by what?

Answer 3

iron, amino acids, B vitamins and Erythropoietin (EPO)

Question 4

what do all leukocytes have in common?

Answer 4

they all originate from hemocytoblasts

Question 5

myeloid stem cells give direct rise to myeloblasts and monoblasts. What do each of them give rise too?

Answer 5

myeloblasts–> eosinophils, neutrophils and basophils

monoblasts–> monocytes

Question 6

what is the order in which lymphocytes are developed?

Answer 6

hemocytoblasts–> lymphoid stem cells–> lymphoblast–> prolymphocytes –> lymphocytes

Question 7

what is erythropointin and where does it come from?

Answer 7

cytokine that induces stem cells to RBC. released by the kidney when oxygen levels are low.