VDJ recombination 1 Flashcards
1
Q
how many types of light chain constant regions are there
A
2
2
Q
how many types of heavy chain constant regions are there
A
5
3
Q
how many hyper variable regions are there
A
3
4
Q
what do hyper variable region do
A
they generate a high level of antigen specificity
5
Q
how is the variable region generated
A
by joining individual gene segments in the VDJ recombination reaction
6
Q
which direction does recombination take place
A
unidirectionally
7
Q
what does recombination between individual gene segments rely on
A
it relies on the recognition of recombination signal sequences rss by RAG proteins
8
Q
describe the RAG 1 protein
A
active region is C-terminal core. active site DDE motif.
9
Q
describe the RAG2 protein
A
active region is N terminal core. C terminus has PHD finger for chromatin binding.
10
Q
A
