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Pharmacology Midterms > Vaughan-Williams Classification > Flashcards

Vaughan-Williams Classification Flashcards

(59 cards)

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1
Q

What action potential does SODIUM channel blockers target

A

Cardiac

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2
Q

What class target the INACTIVATED sodium channel

A

1B

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3
Q

Class - Affinity - Rate
1A
1B
1C

A

Open - Slow
Inactivated - Rapid
Open - Very slow

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4
Q

What class of sodium channel blockers is RISKY? Because?

A

1A
Antiarrhythmic but pro-arrhythmic

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5
Q

Drugs under 1A sodium channel blockers

A

(DQP)
Disopyramide
Quinidine
Procainamide

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6
Q

EFFECTS of class 1A sodium channel blockers

A

SLOWS phase 0 depolarization
PROLONGS action potential (increase refractory period) and QT interval (QRS duration) = TDP
SLOWS conduction velocity

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7
Q

Quinidine
Isomer of __________
Adverse effect __________

A

Quinine (alkaloid)
Cinchonism
Anti-malaria

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8
Q

Triad of cinchonism

A

Headache
Dizziness
Tinnitus

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9
Q

Procainamide
Derivative of __________
Adverse effect __________

A

Procaine (Local anesthetic)
Reversible SLE same with hydralazine

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10
Q

A fatal arrhythmic condition

A

Torsades de pointes

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11
Q

Drugs under 1B sodium channel blockers

A

Tomato, Mayo, Lettuce, Photato

Tocainide
Mexiletine
Lidocaine
Phenytoin

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12
Q

Effects of 1B sodium channel blockers

A

Shortens action potential
No effect on conduction velocity
More pronounced in ischemic tissues

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13
Q

Very SLOW dissociation means

A

More pronounced effect

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14
Q

Drugs under 1C sodium channel blockers

A

More, Enlarged, Fries, Please

Morisizine
Encainide
Flecainide
Propafenone

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15
Q

Mexiletine is an analogue of __________ that is not susceptible to __________

A

Lidocaine
FPE

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16
Q

Mexiletine is indicated for

A

Long term treatment of life threatening ventricular arrhythmia

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17
Q

Propafenone is indicated for

A

Supraventricular Tachycardia
Ventricular arrhythmia

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18
Q

Effects of 1C sodium channel blockers

A

SLOWS phase 0 depolarization and conduction velocity
No to minimal effect on action potential duration

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19
Q

What class targets the CARDIAC action potential

A

Class 1 sodium channel blockers
Class 3 potassium channel blockers

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20
Q

What class targets the NODAL action potential

A

Class 2 beta blockers
Class 4 calcium channel blockers

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21
Q

Drugs under class 2 beta blockers

A

Pro si EsMe

Esmolol
Metoprolol
Propanolol

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22
Q

Effects of class 2 beta blockers

A

Delays slope of phase 4 (SA)
Prolong repolarization (AV)
- Chrono and dromo

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23
Q

What is Chronotropy

A

Heart rate

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24
Q

What is dromotropy

Study These Flashcards
A

Conduction velocity
How fast the IMPULSE

25
Indication of beta blockers
Atrial fibrillation
26
Drugs under Class 3 potassium channel blockers
Dronaderone Sotalol Dofetilide Ibutilide Amiodarone
27
Effects of class 3 potassium channel blockers
PROLONGS ventricular action potential
28
What class 3 potassium channel blockers is NON-IODINATED and had no effect on thyroid
Dronaderone
29
What drug is both a POTASSIUM channel blockers and a BETA blocker
Sotalol
30
What drug is indicated for VT and atrial arrhythmia
Dofetilide
31
Amiodarone contains how many percent of iodine
32%
32
Amiodarone __________ is required Half life is __________
Loading doses Extremely long
33
What drug is had a BROAD spectrum of activity
Amiodarone
34
What does amiodarone block
Sodium, potassium and calcium channels Beta-adrenoreceptors
35
Effects of amiodarone
Decrease SA node automaticity and AV conduction velocity Increase PR and QT interval
36
Indications for amiodarone
VT SVT AF Flutter
37
DRUG PECULIARITIES of amiodarone
High efficacy, low incidence of TDP No reverse use dependence
38
Amiodarone is an enzyme ___________ of the metabolism of
Inhibitor Digoxin, Flecainide, Phenytoin, Procainamide and Warfarin= increase effect
39
Major metabolite of amiodarone
Desethylamiodarone
40
Amiodarone and it's metabolite is highly
Lipophilic
41
An autoregulatory phenomenon whereby large amount of Iodine acutely inhibits thyroid hormone
Wolff-chaikoff effect (Thyroid abnormalities)
42
Drugs under class 4 calcium channel blockers
Verapamil Diltiazem
43
Effects of class 4 calcium channel blockers
Prolong repolarization Decrease AV conduction velocity - ino Little effect on SA node and heart rate
44
Indications of class 4 calcium channel blockers
Atrial fibrillation Acute supraventricular Tachycardia
45
Miscellaneous agents include
Adenosine Magnesium Potassium Cardioglycosides Ivabradine
46
Adenosine is an agonist to
Adenosine 1 receptors
47
What does adenosine activated and suppress
Activation of Ach-sensitive POTASSIUM channels Suppress CALCIUM dependent action potential
48
Adenosine Half life __________ DOC for __________
Prompt conversion of paroxysmal SVT to sinus rhythm
49
It's deficiency can lead to arrhythmic condition
Magnesium
50
Influences the channels
Magnesium sulfate
51
Both used for digitalis-induced arrhythmia
Magnesium Potassium
52
Indicated for TDP
Magnesium
53
Has significant parasympathomimetic effects
Cardioglycosides
54
Cardioglycosides decrease
SA pacemaker activity AV conductance HR
55
Potassium is for
Atrial fibrillation+HR
56
-chrono and dromo + Ino Means For POTASSIUM
SLOWS heartbeat but STRENGTHENS contraction
57
A NOVEL heart rate lowering drug
Ivabradine
58
What does ivabradine block
If current (Funny current) in SA node
59
What has a beautiful trial in angina pectoris and a shift study of heart failure
Ivabradine

Pharmacology Midterms (4 decks)

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