Vasopressin/Oxytocin drugs Flashcards
What drug can be used to treat nocturnal enuresis?
desmopression
What results from inadequate ADH secretion from posterior pituitary?
Central Diabetes Insipidus
What condition is defined as incomplete
suppression of ADH secretion under hypoosmolar conditions?
yndrome of Inappropriate Secretion of Antidiuretic Hormone (SIADH)
What drug reduces V2-receptor mediated stimulation of adenylyl cyclase?
Lithium
What street drug increases the risk of SIADH?
Methylenedioxy methamphetamine (MDMA)
What psychotropic agents increase the risk of SIADH?
haloperidol, SSRIs, and TCAs
What drug inhibits ADH effect on distal tubule?
Demeclocyline
What results fro inadequate ADH actions of target organs?
Nephrogenic Diabetes Insipidus
What drug can be used instead of octreotide to decrease bleeding in esophageal varices
Vasopressin (via V1)
NSAIDS (indomethacin) and thiazide, along with a low salt/low protein diet, are treatments for what condition?
Nephrogenic Diabetes Insipidus
Chlorpropamide, Carbamazepine, clofibrate, thiazides, and NSAIDs are all additional treatments for what condition?
Central Diabetes Insipidus
V2 receptor antagonists
Tolvaptan and Conivaptan
What is a concern of correcting SIADH too quickly?
cerebellar pontine
myelinolysis
ADH binds which receptor to increase the rate of insertion of aquaporins?
V2
ADH analog
desmopressin (DDAVP)
Does ADH mediate vasocontriction of vasodilation of vascular smooth muscle?
vasoconstriction
How is vasopressin administered?
parenterally
What is the treatment of choice for Central Diabetes Insipidus
Desmopressin
What type of receptors are V1 receptors?
Gq
What type of receptors are V2 receptors?
Gs
Where are V1 receptors located?
Vascular smooth muscle
Where are V2 receptors located?
Kidney
What antibiotic increases the risk of Nephrogenic Diabetes Insipidus?
Demeclocyline (tetracycline antibiotic)
