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DEMS > Vasopressin/Oxytocin drugs > Flashcards

Vasopressin/Oxytocin drugs Flashcards

1
Q

What drug can be used to treat nocturnal enuresis?

A

desmopression

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2
Q

What results from inadequate ADH secretion from posterior pituitary?

A

Central Diabetes Insipidus

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3
Q

What condition is defined as incomplete

suppression of ADH secretion under hypoosmolar conditions?

A

yndrome of Inappropriate Secretion of Antidiuretic Hormone (SIADH)

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4
Q

What drug reduces V2-receptor mediated stimulation of adenylyl cyclase?

A

Lithium

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5
Q

What street drug increases the risk of SIADH?

A

Methylenedioxy methamphetamine (MDMA)

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6
Q

What psychotropic agents increase the risk of SIADH?

A

haloperidol, SSRIs, and TCAs

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7
Q

What drug inhibits ADH effect on distal tubule?

A

Demeclocyline

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8
Q

What results fro inadequate ADH actions of target organs?

A

Nephrogenic Diabetes Insipidus

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9
Q

What drug can be used instead of octreotide to decrease bleeding in esophageal varices

A

Vasopressin (via V1)

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10
Q

NSAIDS (indomethacin) and thiazide, along with a low salt/low protein diet, are treatments for what condition?

A

Nephrogenic Diabetes Insipidus

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11
Q

Chlorpropamide, Carbamazepine, clofibrate, thiazides, and NSAIDs are all additional treatments for what condition?

A

Central Diabetes Insipidus

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12
Q

V2 receptor antagonists

A

Tolvaptan and Conivaptan

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13
Q

What is a concern of correcting SIADH too quickly?

A

cerebellar pontine

myelinolysis

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14
Q

ADH binds which receptor to increase the rate of insertion of aquaporins?

A

V2

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15
Q

ADH analog

A

desmopressin (DDAVP)

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16
Q

Does ADH mediate vasocontriction of vasodilation of vascular smooth muscle?

A

vasoconstriction

17
Q

How is vasopressin administered?

A

parenterally

18
Q

What is the treatment of choice for Central Diabetes Insipidus

A

Desmopressin

19
Q

What type of receptors are V1 receptors?

A

Gq

20
Q

What type of receptors are V2 receptors?

A

Gs

21
Q

Where are V1 receptors located?

A

Vascular smooth muscle

22
Q

Where are V2 receptors located?

A

Kidney

23
Q

What antibiotic increases the risk of Nephrogenic Diabetes Insipidus?

A

Demeclocyline (tetracycline antibiotic)

DEMS (5 decks)

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