Bone drugs

Question 1

Which drugs directly inhibit bone resorption by increasing osteoclast apoptosis and inhibition of prenylation of proteins necessary for osteoclast function?

Answer 1

Bisphosphonates

Question 2

What drug is a Sclerostin antibody and is currently being investigated as a treatment for osteoporosis?

Answer 2

Romosozumab

Question 3

What hormone(s) inhibits bone resorption? t

Answer 3

Calcitonin

Question 4

What is the preferred treatment for Vitamin D repletion in a patient with liver disease?

Answer 4

calcifediol

Question 5

Vitamin D2

Answer 5

ergocalciferol

Question 6

What is the preferred treatment for Vitamin D repletion?

Answer 6

cholecalciferol

Question 7

What protein binds RANK to increase osteoclast activity?

Answer 7

RANK-L

Question 8

1α-OHD3 (alternative to calcitriol)

Answer 8

Dihydrotachysterol

Question 9

Which drug class can increase the risk of osteonecrosis of the jaw?

Answer 9

Bisphosphonates

Question 10

What drug class are Alendronate, Risedronate, Ibandronate, and Zoledronate

Answer 10

Bisphosphonates

Question 11

What hormone(s) stimulates the formation of 1,25(OH)2D3 at the kidney?

Answer 11

PTH

Question 12

What hormone prevents osteoclast activation by increase osteoblast production of OPG?

Answer 12

Estrogen

Question 13

What hormone(s) stimulates the reabsorption of phosphate at the kidney?

Answer 13

1,25(OH)2D3

Question 14

What is the most effective drug for prevention and treatment of
osteoporosis?

Answer 14

Bisphosphonates

Question 15

What treatment of osteoporosis is not indicated in patients at risk for heart disease?

Answer 15

estrogen

Question 16

Which class of diuretics increases calcium excretion in the kidney?

Answer 16

Loop diuretics

Question 17

Synthetic amino terminal human PTH fragment

Answer 17

Teriparatide

Question 18

Which drugs prevent the RANK-RANKL interaction?

Answer 18

Raloxifene, Estrogen, Denosumab

Question 19

What drug class is Raloxifene?

Answer 19

Selective Estrogen Receptor Modulators (SERMs)

Question 20

1,25-Dihydroxyvitamin D3

Answer 20

calcitriol

Question 21

What hormone(s) stimulates the reabsorption of calcium at the kidney?

Answer 21

1,25(OH)2D3 and PTH

Question 22

What hormone(s) stimulate the absorption of Calcium and Phosphate from the intestine?

Answer 22

1,25(OH)2D3

Question 23

What are 3 non-pharmacologic therapies to improve bone density?

Answer 23

(1) diet (calcium: 1500 mg/d; Vitamin D: 800 IU/d],
(2) exercise (weight-bearing)
(3) smoking cessation

Question 24

What hormone(s) stimulates the osteoblasts and osteoclasts to promote bone resorption and formation?

Answer 24

1,25(OH)2D3 and PTH

Question 25

What drug is indicated in the prevention and treatment of osteoporosis in a patient that can’t tolerate BP or is at increased risk for breast cancer?

Answer 25

Raloxifene (SERM)

Question 26

What hormones increase RANK-L, decrease OPG, and antagonize Vitamin D-stimulated intestinal calcium transport?

Answer 26

Glucocorticoids

Question 27

What is the preferred treatment for Vitamin D repletion in a patient with renal disease?

Answer 27

calcitriol

Question 28

What drug ncreases osteoblastic activity and bone formation with intermittent administration?

Answer 28

Teriparatide

Question 29

What protein binds RANK to decrease osteoclast activity?

Answer 29

osteoprotegerin (OPG)

Question 30

Monoclonal Antibody to RANK-L

Answer 30

Denosumab

Question 31

What hormone(s) inhibits the formation of 1,25(OH)2D3 at the kidney?

Answer 31

FGF23

Question 32

Which class of diuretics increases calcium reabsorption in the kidney?

Answer 32

Thiazides

Question 33

25-Hydroxyvitamin D3

Answer 33

calcifediol

Question 34

Vitamin D3

Answer 34

cholecalciferol

Question 35

What hormone(s) stimulates the excretion of phosphate at the kidney?

Answer 35

PTH and FGF23