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PSL > Vasodilators > Flashcards

Vasodilators Flashcards

1
Q

Why does increasing K+ channel opening relax vascular smooth muscle?

A

K+ flux sets the membrane potential
The longer the K+ channels are open, the closer the membrane potential is to the K+ equilibrium potential. The closer the membrane potential is to K+ equilibrium potential, the harder it is to depolarize the membrane enough to open voltage-gated Ca2+ channels

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2
Q

which PDE inhibitors inhibit the breakdown of cAMP? cGMP?

A

PDE3/cAMP: amrinone, milrinone
PDE5/cGMP: dipyridamole, sildenafil, tadalafil, vardenafil

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3
Q

Levitra and Cialis are _______________ (more/less) selective for PDE5 than Viagra

A

more

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4
Q

Cialis has a _____________ (shorter/longer) duration of action than Viagra or Levitra

A

longer

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5
Q

Why are PDE5 inhibitors contraindicated with organic nitrates?

A

precipitous drop in blood pressure since both drugs increase accumulation of cGMP

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6
Q
A
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PSL (8 decks)

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