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Pharmacology > Vasoactive Peptides > Flashcards

Vasoactive Peptides Flashcards

1
Q

transmitters in the autonomic and central nervous systems

A

Vasoactive peptides

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2
Q

angiotensin II, VD or VC?

A

Vasoconstrictor

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3
Q

vasopressin, VD or VC

A

Vasoconstrictor

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4
Q

endothelins VD, or VC?

A

Vasoconstrictor

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5
Q

neuropeptide Y VD, or VC

A

Vasoconstrictor

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6
Q

urotensin VD or VC

A

Vasoconstrictor

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7
Q

(bradykinin and related kinins VD or VC

A

Vasodilator

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8
Q

natriuretic peptides,

A

Vasodilator

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9
Q

vasoactive intestinal peptide

A

Vasodilator

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10
Q

substance P

A

Vasodilator

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11
Q

neurotensin

A

Vasodilator

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12
Q

calcitonin
gene-related peptide

A

Vasodilator

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13
Q

adrenomedullin

A

Vasodilator

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14
Q

Inactive form of angiotensin 1

A

angiotensinogen

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15
Q

Modulators of renin release aside from synthesis of renin

A
  1. Macula densa
  2. Renal baroreceptor
  3. Sympathetic NS
  4. Angiotensin
  5. Intracellular signaling pathways
  6. Pharmacologic alteration of renin release
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16
Q

A specialized region of distal convoluted tubule

A

Macula Densa

17
Q

where renin is released/regulated

A

Macula densa

18
Q

Relationship between NACL deliver/concentration and renin release

A

Inversely proportional

19
Q

Prostaglandin E2 and Nitric Oxide

A

Stimulate renin release

20
Q

Adenosine

A

Renin release inhibitor

21
Q

If NACL is low, filtrate flow or urine output is?

A

reduces; low

22
Q

Renal vascular baroreceptor relationship with renal artery pressure and renin release

A

Inverse relationship

24
Q

Low BP and renin release relationship

25
Q

Renin, a vasodilator or vasoconstrictor?

A

Vasoconstrictor

26
Q

Enzyme which converts Angiotensin I to Angiotensin II

A

Converting enzyme

27
Q

Angiotensin II, vasodilator or vasoconstrictor?

A

POTENT VASOCONSTRICTOR

28
Q

ANG II action on renin release

29
Q

2nd messengers/ intracellular messengers

A

cAMP, cGMP, and free cytosolic Calcium (Ca2+) concentration

30
Q

cAMP and renin relationship

A

directly proportional

31
Q

adenyly cyclase and renin relationship

A

directly proportional

32
Q

Drugs that alter renin release

A
  1. Vasodilators
  2. B-Adrenoceptor agonists
  3. A-adrenoceptor antagonists
  4. Phosphodiesterase inhibitors
  5. most diuretics
  6. anesthetics
33
Q

most important substrate of ACE

34
Q

Ace Inhibitors

A

captopril
enalapril
lisinopril

35
Q

Bradykinin MOA

A

activates cough reflex

36
Q

ANG II mechanisms in raising blood pressure (4)

A
  1. Vasoconstriction
  2. Aldosterone release
  3. ADH Release
  4. cell growth
37
Q

Drugs that interfere with renin release

A

Propanolol
Ace inhibitors

38
Q

ANG receptor blockers

A

Losartan
Olmesartan
Valsartan
Azilsartan
Condesartan
Telmisartan
Irbesartan

Pharmacology (3 decks)

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