Eicosanoids, prostaglandins, thromboxanes, leukotrienes, and related compounds

Question 1

Carboxylic acid having 20 carbon. Pro inflammatory, and produces the eicosanoids. Synthesized from leinolic acic.

Answer 1

Arachidonic acid

Question 2

Eicosanoid pathways

Answer 2

Cyclooxygenase
Lipoxygenase
CYP 450 Epoxygenase

Question 3

Products of COX pathway

Answer 3

Prostanoids
- prostaglandins
- prostacyclin
- thromboxane

Question 4

VD or VC, PGF

Answer 4

Vasoconstrictor

Question 5

VD or VC, PGE

Answer 5

Vasodilator

Question 6

VD or VC, Prostacyclin (PGI)

Answer 6

Vasodilator

Question 7

Type of COX for cytoprotective agents

Answer 7

COX 1

Question 8

Type of COX for inflammation and pain

Answer 8

COX 2

Question 9

Products of LOX

Answer 9

Hydroperoxyeicosatetraenoic acid (HPETE)

Question 10

Products of HPETE

Answer 10

HETE
Leukotriene
Lipoxin

Question 11

Factors that determine the type of eicosanoid synthesized

Answer 11

Cell type
Cell stimulus
Substrate lipid species

Question 12

For smooth muscle relaxation, dilates corpus cavernosum in the penis, the CaVerJect

Answer 12

Alprostadil (PGE1)

Question 13

Constrictor and induces labor

Answer 13

Dinoprostone (PGE2)

Question 14

Prevents stomach ulceration, induce abortion (contracts uterus)

Answer 14

Misoprostol (PGE1)

Question 15

Reduce IOP in glaucoma

Answer 15

Latanoprost PGF2

Question 16

Vasodilator, inhibitor of platelet aggregation

Answer 16

Prostacyclin (PGI2)

Question 17

Vasoconstrictor, platelet aggregator

Answer 17

Thromboxane (TXA2)

Question 18

Target of LT biosynthesis inhibitors

Answer 18

5-LOX activating protein

Question 19

reduce proinflammatory leukotrience mediators

Answer 19

FLAP inhibitors

Question 20

Associated to lipoxins; are pro-inflammatory

Answer 20

Hepoxilins

Question 21

non-enzymatic pathway of eicosanoids

Answer 21

Isoeicosanoid pathway