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Vasoactive Peptides Flashcards

1
Q

vasoconstrictors

A

ANG II
endothelins
NPY

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2
Q

vasodilators

A

bradykinin
natriuretic peptides (ANP & BNP)
VIP
CGRP

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3
Q

ANG II stimulates the release of

A

Aldosterone

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4
Q

ANG II effects

A

Vasoconstrictor
Stimulates aldosterone release
Increases peripheral vascular resistance
Causes renal sodium retention through aldosterone
Facilitates the release of norepi
Cardiac remodeling

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5
Q

Angiotensin antagonist

A

ACE inhibitors (captopril, enalapril)
ARBs (losartan, valsartan)

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6
Q

ARBs are inhibitors at which receptor

A

ANG II AT1 receptor

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7
Q

Aliskiren moa

A

renin inhibitor
reduces ANG I and II and aldosterone secretion

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8
Q

Renin-angiotensin antagonists used in htn

A

Aliskiren
Captopril, enalapril
Losartan, valsartan

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9
Q

Aliskiren toxicity

A

angioedema
renal impairment

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10
Q

ACE inhibitors toxicity

A

cough
teratogenic
hyperkalemia

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11
Q

ARBs toxicity

A

teratogenic
hyperkalemia

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12
Q

Kinin antagonists

A

Ecallantide
Icatibant

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13
Q

Icatibant blocks which receptor

A

B2 bradykinin

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14
Q

kinin antagonist clinical

A

hereditary angioedema

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15
Q

Ecallantide toxicity

A

hypersensitivity reactions

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16
Q

Icatibant toxicity

A

hepatotoxic
hypersensitivity reactions

17
Q

Natriuretic peptides

A

atrial natriuretic peptide ANP
brain natriuretic peptide BNP

18
Q

Nesiritide moa and clinical

A

BNP receptor agonist
acute heart failure

19
Q

endothelin antagonist

A

bosentran
macitentan

20
Q

bosentran and macitentan moa and clinical

A

ETa and ETb receptor antagonists
pulmonary htn

21
Q

Nesiritide toxicity

A

renal damage
hypotension

22
Q

endothelin antagonist toxicity

A

hepatic impairment
teratogenic

23
Q

Neurokinin antagonist

A

Aprepitant
Capsaicin

24
Q

Aprepitant clinical

A

antiemetic for chemotherapy induced vomiting

25
Capsaicin clinical
topical for painful conditions (joints, post-herpetic neuralgia)
26
Aprepitant toxicity
asthenia hiccups
27
Capsaicin toxicity
burning stinging erythema
28
badykinin causes the production of
IP3 DAG cAMP nitric oxide prostaglandins
29
blood levels of endogenous BNP can be used as a diagnostic marker for
heart failure
30
neurokinins include
substance P neurokinin A neurokinin B
31
in tissues bradykinin causes
inflammation edema vasodilation pain
32
substance P moa
arteriolar vasodilation & venoconstriction

Blood Pharma (3 decks)

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