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Blood Pharma > Vasoactive Peptides > Flashcards

Vasoactive Peptides Flashcards

1
Q

vasoconstrictors

A

ANG II
endothelins
NPY

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2
Q

vasodilators

A

bradykinin
natriuretic peptides (ANP & BNP)
VIP
CGRP

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3
Q

ANG II stimulates the release of

A

Aldosterone

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4
Q

ANG II effects

A

Vasoconstrictor
Stimulates aldosterone release
Increases peripheral vascular resistance
Causes renal sodium retention through aldosterone
Facilitates the release of norepi
Cardiac remodeling

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5
Q

Angiotensin antagonist

A

ACE inhibitors (captopril, enalapril)
ARBs (losartan, valsartan)

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6
Q

ARBs are inhibitors at which receptor

A

ANG II AT1 receptor

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7
Q

Aliskiren moa

A

renin inhibitor
reduces ANG I and II and aldosterone secretion

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8
Q

Renin-angiotensin antagonists used in htn

A

Aliskiren
Captopril, enalapril
Losartan, valsartan

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9
Q

Aliskiren toxicity

A

angioedema
renal impairment

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10
Q

ACE inhibitors toxicity

A

cough
teratogenic
hyperkalemia

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11
Q

ARBs toxicity

A

teratogenic
hyperkalemia

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12
Q

Kinin antagonists

A

Ecallantide
Icatibant

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13
Q

Icatibant blocks which receptor

A

B2 bradykinin

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14
Q

kinin antagonist clinical

A

hereditary angioedema

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15
Q

Ecallantide toxicity

A

hypersensitivity reactions

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16
Q

Icatibant toxicity

A

hepatotoxic
hypersensitivity reactions

17
Q

Natriuretic peptides

A

atrial natriuretic peptide ANP
brain natriuretic peptide BNP

18
Q

Nesiritide moa and clinical

A

BNP receptor agonist
acute heart failure

19
Q

endothelin antagonist

A

bosentran
macitentan

20
Q

bosentran and macitentan moa and clinical

A

ETa and ETb receptor antagonists
pulmonary htn

21
Q

Nesiritide toxicity

A

renal damage
hypotension

22
Q

endothelin antagonist toxicity

A

hepatic impairment
teratogenic

23
Q

Neurokinin antagonist

A

Aprepitant
Capsaicin

24
Q

Aprepitant clinical

A

antiemetic for chemotherapy induced vomiting

25
Q

Capsaicin clinical

A

topical for painful conditions (joints, post-herpetic neuralgia)

26
Q

Aprepitant toxicity

A

asthenia
hiccups

27
Q

Capsaicin toxicity

A

burning
stinging
erythema

28
Q

badykinin causes the production of

A

IP3
DAG
cAMP
nitric oxide
prostaglandins

29
Q

blood levels of endogenous BNP can be used as a diagnostic marker for

A

heart failure

30
Q

neurokinins include

A

substance P
neurokinin A
neurokinin B

31
Q

in tissues bradykinin causes

A

inflammation
edema
vasodilation
pain

32
Q

substance P moa

A

arteriolar vasodilation & venoconstriction

Blood Pharma (3 decks)

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