Hematopoietic factors

Question 1

Most common type of anemia

Answer 1

Iron deficiency anemia

Question 2

Pernicious anemia

Answer 2

Vit B12 deficiency anemia caused by a defect in the synthesis of intrinsic factor.

Question 3

Excess iron is stored in

Answer 3

GI epithelial cells, macrophages and hepatocytes

Question 4

Dietary iron supplements

Answer 4

Ferrous sulphate
Ferrous gluconate
Ferrous fumarate

Question 5

Parenteral iron preparations

Answer 5

Iron dextran
Sodium ferric gluconate complex
Iron sucrose

Question 6

Ferumoxytol?

Answer 6

Super-paramagnetic iron oxide
Interferes with MRI studies

Question 7

Acute iron overdose

Answer 7

Necrotizing gastroenteritis
Shock
Metabolic acidosis
Coma
Death

Question 8

Chronic iron overload

Answer 8

Hemochromatosis (damages heart, liver, pancreas)

Question 9

Hemochromatosis commonly in

Answer 9

Individuals with an inherited abnormality of iron absorption
Those who receive frequent transfusions for hemolytic disorders (thalassemia major)

Question 10

Treatment of acute iron intoxication

Answer 10

Deferoxamine

Question 11

Treatment of chronic iron toxicity

Answer 11

Phlebotomy (hereditary hemochromatosis)
Parenteral deferoxamine or deferasirox (hemochromatosis due to frequent transfusions)

Question 12

Vitamin B12 forms available

Answer 12

Cyanocobalamin
Hydroxocobalamin

Question 13

Vit B12 binds to _____ for plasma transport

Answer 13

Transcobalamin II

Question 14

Vitamin B12 essential reactions

Answer 14

Conversion of methyl-malonyl-coenzyme A to succinyl-CoA
Conversion of homocysteine to methionine

Question 15

Which precursor is required for DNA synthesis

Answer 15

Deoxythymidylate (dTMP)

Question 16

Vitamin B12 clinical

Answer 16

Pernicious anemia
Anemia caused by gastric resection

Question 17

Hematopoitic growth factors?

Answer 17

Erythropoiesis-stimulating agents (ESAs)
Myeloid growth factors (G-CSF & GM-CSF)
Megakaryocyte growth factors

Question 18

Erythropoietin produced by

Answer 18

Kidney

Question 19

Reduction in erythropoietin synthesis cause

Answer 19

Anemia of renal failure

Question 20

Human erythropoietin

Answer 20

Epoetin alfa

Question 21

ESA therapy complications

Answer 21

Hypertension
Thrombosis

Question 22

Myeloid growth factors

Answer 22

Granulocyte colony stimulating factor G-CSF (filgrastim)
Granulocyte macrophage colony stimulating factor GM-CSF (sargramostim)

Question 23

Myeloid growth factors clinical

Answer 23

Accelerate the recovery of neutrophils after cancer chemotherapy
Treat aplastic anemia, congenital neutropenia

Question 24

G-CSF toxicity

Answer 24

Bone pain

Question 25

GM-CSF toxicity

Answer 25

Fever Arthralgias Capillary damage with edema

Question 26

Megakaryocyte growth factors

Answer 26

Oprelvekin (IL-11) Romiplostin Eltrombopag

Question 27

Oprelvekin clinical

Answer 27

Secondary prevention of thrombocytopenia in patients undergoing cytotoxic chemotherapy for nonmyeloid cancers

Question 28

Romiplostim clinical

Answer 28

Idiopathic thrombocytopenia purpura ITP

Question 29

Oprelvekin toxicity

Answer 29

Fatigue Headache Dizziness Anemia Transient atrial arrhythmias Fluid accumulation in the lungs