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Blood Pharma > Hematopoietic factors > Flashcards

Hematopoietic factors Flashcards

1
Q

Most common type of anemia

A

Iron deficiency anemia

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2
Q

Pernicious anemia

A

Vit B12 deficiency anemia caused by a defect in the synthesis of intrinsic factor.

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3
Q

Excess iron is stored in

A

GI epithelial cells, macrophages and hepatocytes

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4
Q

Dietary iron supplements

A

Ferrous sulphate
Ferrous gluconate
Ferrous fumarate

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5
Q

Parenteral iron preparations

A

Iron dextran
Sodium ferric gluconate complex
Iron sucrose

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6
Q

Ferumoxytol?

A

Super-paramagnetic iron oxide
Interferes with MRI studies

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7
Q

Acute iron overdose

A

Necrotizing gastroenteritis
Shock
Metabolic acidosis
Coma
Death

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8
Q

Chronic iron overload

A

Hemochromatosis (damages heart, liver, pancreas)

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9
Q

Hemochromatosis commonly in

A

Individuals with an inherited abnormality of iron absorption
Those who receive frequent transfusions for hemolytic disorders (thalassemia major)

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10
Q

Treatment of acute iron intoxication

A

Deferoxamine

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11
Q

Treatment of chronic iron toxicity

A

Phlebotomy (hereditary hemochromatosis)
Parenteral deferoxamine or deferasirox (hemochromatosis due to frequent transfusions)

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12
Q

Vitamin B12 forms available

A

Cyanocobalamin
Hydroxocobalamin

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13
Q

Vit B12 binds to _____ for plasma transport

A

Transcobalamin II

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14
Q

Vitamin B12 essential reactions

A

Conversion of methyl-malonyl-coenzyme A to succinyl-CoA
Conversion of homocysteine to methionine

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15
Q

Which precursor is required for DNA synthesis

A

Deoxythymidylate (dTMP)

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16
Q

Vitamin B12 clinical

A

Pernicious anemia
Anemia caused by gastric resection

17
Q

Hematopoitic growth factors?

A

Erythropoiesis-stimulating agents (ESAs)
Myeloid growth factors (G-CSF & GM-CSF)
Megakaryocyte growth factors

18
Q

Erythropoietin produced by

A

Kidney

19
Q

Reduction in erythropoietin synthesis cause

A

Anemia of renal failure

20
Q

Human erythropoietin

A

Epoetin alfa

21
Q

ESA therapy complications

A

Hypertension
Thrombosis

22
Q

Myeloid growth factors

A

Granulocyte colony stimulating factor G-CSF (filgrastim)
Granulocyte macrophage colony stimulating factor GM-CSF (sargramostim)

23
Q

Myeloid growth factors clinical

A

Accelerate the recovery of neutrophils after cancer chemotherapy
Treat aplastic anemia, congenital neutropenia

24
Q

G-CSF toxicity

A

Bone pain

25
Q

GM-CSF toxicity

A

Fever
Arthralgias
Capillary damage with edema

26
Q

Megakaryocyte growth factors

A

Oprelvekin (IL-11)
Romiplostin
Eltrombopag

27
Q

Oprelvekin clinical

A

Secondary prevention of thrombocytopenia in patients undergoing cytotoxic chemotherapy for nonmyeloid cancers

28
Q

Romiplostim clinical

A

Idiopathic thrombocytopenia purpura ITP

29
Q

Oprelvekin toxicity

A

Fatigue
Headache
Dizziness
Anemia
Transient atrial arrhythmias
Fluid accumulation in the lungs

Blood Pharma (3 decks)

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