Vasculitis Flashcards
Name two large vessel vasculitis
Giant Cell Arteritis
Takayasu’s arteritis
Name two medium vessel vasculitis
Polyarteritis Nodosa
Kawasaki disease
Buerger’s disease
Small vessel
pANCA - Churg Strauss, Microscopic Polyangitis
cANCA - Granulomatosis with polyangitis
ANCA -‘ve - Henoch Schonlein Purpura, good pastures disease
Giant cell Arteritis - four key symptoms
Painless loss of vision
Jaw claudication
Headache
Temporal artery & scalp tenderness
What blood tests in GCA?
ESR (up), ALP (UP) , HB (down)
How to treat GCA
Oral prednisolone 40-60mg
Who gets Takayasu’s arteritis
Asian women who are less than 40 years . Giant cells in the aortic arch at branches.
3 key features of Takayasu’s arteritis
Weak pulses in upper extremities
Visual disturbance
Hypertension
What lab test in Takayasu’s
ESR
How treat Takayasu’s
Corticosteroids
Who gets polyarteritis Nodosa?
Young, male adults. Immune confuses endothelium for Hep B
Features of polyarteritis nodosa?
Skin -> Rash
Renal -> HTN
GIT -> Melaena and abdo pain
How to diagnose polyarteritis nodosa?
String of beads on angiogram
Who gets Kawasaki’s disease?
Young children
What are the 5 key features of Kawasaki’s disease?
C onjunctivitis R ash - polymorphic on trunk A denopathy - cervical lympg S trawberry tounge H ands and feet (swollen and rash)
What happens to bloods in Kawasaki’s?
Anaemia
Raised WBC, LFT, ESR, CRP
Management of kawasaki’s
IV Ig + Aspirin
What did granulamoatosis polyangitis used to be called?
Wegners disease
What antibody is found in granulomatosis with polyangitis?
cANCA
What are the key features of GPA?
URT - chronic sinusitis, epistaxis, saddle-nose deformity
LRT - cough, haemoptysis, pleuritis
Renal - Rapidly progressive GN, haematuria & proteinuria
Other - Palpable purpura, ocular conjucticitis, keratitis, uveitis
How do you treat Wegners GPA?
Pred & cyclophosphamide
What is the autoantibody for eosinophillic GPA?
pANCA
What are the key features of eosinophillic GPA?
Late onset asthma
Eosinophillia
Paranasal sinusitis
Rapid progress GN
What investigations would you do in EGPA?
WBC -> Raised eosinophils
X-ray
Spirometry
ECG
Management for eGPA?
Steroids and cyclophosphamide
Describe Henoch Schonleins vasculitits
A child aged 3-8 years presents with a rash on buttocks following an URTI
What are the key features of henoch schonleins vasculitits?
Palpable purpuric rash on legs Colicky abdominal pain Arthralgia Post-URT Polyarthritis
What is the management of Henoch Schonlein’s?
Pain relief
Supportive
Steroids if severe
