Vasculitis

Question 1

Name two large vessel vasculitis

Answer 1

Giant Cell Arteritis

Takayasu’s arteritis

Question 2

Name two medium vessel vasculitis

Answer 2

Polyarteritis Nodosa
Kawasaki disease
Buerger’s disease

Question 3

Small vessel

Answer 3

pANCA - Churg Strauss, Microscopic Polyangitis
cANCA - Granulomatosis with polyangitis
ANCA -‘ve - Henoch Schonlein Purpura, good pastures disease

Question 4

Giant cell Arteritis - four key symptoms

Answer 4

Painless loss of vision
Jaw claudication
Headache
Temporal artery & scalp tenderness

Question 5

What blood tests in GCA?

Answer 5

ESR (up), ALP (UP) , HB (down)

Question 6

How to treat GCA

Answer 6

Oral prednisolone 40-60mg

Question 7

Who gets Takayasu’s arteritis

Answer 7

Asian women who are less than 40 years . Giant cells in the aortic arch at branches.

Question 8

3 key features of Takayasu’s arteritis

Answer 8

Weak pulses in upper extremities
Visual disturbance
Hypertension

Question 9

What lab test in Takayasu’s

Answer 9

ESR

Question 10

How treat Takayasu’s

Answer 10

Corticosteroids

Question 11

Who gets polyarteritis Nodosa?

Answer 11

Young, male adults. Immune confuses endothelium for Hep B

Question 12

Features of polyarteritis nodosa?

Answer 12

Skin -> Rash
Renal -> HTN
GIT -> Melaena and abdo pain

Question 13

How to diagnose polyarteritis nodosa?

Answer 13

String of beads on angiogram

Question 14

Who gets Kawasaki’s disease?

Answer 14

Young children

Question 15

What are the 5 key features of Kawasaki’s disease?

Answer 15

C onjunctivitis
R ash - polymorphic on trunk
A denopathy - cervical lympg
S trawberry tounge 
H ands and feet (swollen and rash)

Question 16

What happens to bloods in Kawasaki’s?

Answer 16

Anaemia

Raised WBC, LFT, ESR, CRP

Question 17

Management of kawasaki’s

Answer 17

IV Ig + Aspirin

Question 18

What did granulamoatosis polyangitis used to be called?

Answer 18

Wegners disease

Question 19

What antibody is found in granulomatosis with polyangitis?

Answer 19

cANCA

Question 20

What are the key features of GPA?

Answer 20

URT - chronic sinusitis, epistaxis, saddle-nose deformity
LRT - cough, haemoptysis, pleuritis
Renal - Rapidly progressive GN, haematuria & proteinuria
Other - Palpable purpura, ocular conjucticitis, keratitis, uveitis

Question 21

How do you treat Wegners GPA?

Answer 21

Pred & cyclophosphamide

Question 22

What is the autoantibody for eosinophillic GPA?

Answer 22

pANCA

Question 23

What are the key features of eosinophillic GPA?

Answer 23

Late onset asthma
Eosinophillia
Paranasal sinusitis
Rapid progress GN

Question 24

What investigations would you do in EGPA?

Answer 24

WBC -> Raised eosinophils
X-ray
Spirometry
ECG

Question 25

Management for eGPA?

Answer 25

Steroids and cyclophosphamide

Question 26

Describe Henoch Schonleins vasculitits

Answer 26

A child aged 3-8 years presents with a rash on buttocks following an URTI

Question 27

What are the key features of henoch schonleins vasculitits?

Answer 27

Palpable purpuric rash on legs 
Colicky abdominal pain 
Arthralgia 
Post-URT 
Polyarthritis

Question 28

What is the management of Henoch Schonlein’s?

Answer 28

Pain relief
Supportive
Steroids if severe