Vasculitis

Question 0

Venulitis with palpable purpura (raised bruises)

Answer 0

• most commonly HSN angiitis
• serum sickness
• RMSF (likes upper extremity)
• cancers

Question 1

Vasculitis

Answer 1

Inflammation of vessels that result in ischemia

• primary and secondary
• often results in multi organ and skin dysfunction
• cryoglobinemia
• C\P ANCA (C ANCA Wegeners; P in everything else)

Question 2

Palpable purpura on LUX, systemic symptoms (fever malaise)

Answer 2

• drug induced vasculitis

- allopurinol, gold, thiazides, sulfas, phenytoin, PCN

Question 3

Palpable purpura (butt and legs), arthritis, GI, Kidney diseas more common in kids

Answer 3

Henoch-Shonlein purpura

• usually self limiting
• may cause intusseception

Question 4

HSN vasculitis following Hep C infxn, with immune complex deposits

Answer 4

• cryoglobinemia

Question 5

Painful oral ulcerations, plus 2: recurrent genital lesions, eye, skin, positive pathergy test

Answer 5

Bechets syndrome

- typically self resolving

Question 6

Bechets syndrome

Answer 6

Painful oral ulcerations, plus 2: recurrent genital lesions, eye, skin, positive pathergy test
- typically self-resolving

Question 7

Vasculitis NOT involving skin: kidney, peripheral neuropathy, bowel disease. Fever weightloss, abdominal, MSk pain

Answer 7

• polyarteritis nodosa
• no lung involvement
• lesions all different ages

Question 8

PAN identifying features

Answer 8

• aneurysms
• pulmonary arteries NOT involved
• venules not involved
• ANCA not involved
• kidneys most commonly involved: nephrotic syndrome

Question 9

Pain, paresthesis, and sensory loss in PAN

Answer 9

• mononeuritis multiplex

- necrotizing neuritis of vaso nervorum

Question 10

Gangrene, livedo reticularis, urticaria and purpura

Answer 10

• PAN skin manifestation

Question 11

Treatment for most of the vasculitises

Answer 11

• high dose prednisone and cyclophosphamide

Question 12

Pulmonary capillaries and glomerulonephritis, diffuse alviolar, P-ANCA positive, hemorrhage complication:
More common than PAN

Answer 12

Microscopic polyangiitis

Question 13

Eosinophilic rhinitis and asthma with vasculitis

Answer 13

• Churg-Strauss
• confused for allergies
• trt: with prednisone and cyclophosphamide
• high mortality if its not treated

Question 14

renal, upper and lower resp lesions, saddle nose deformity, C-ANCA

Answer 14

Wegeners (granulomatous polyangiitis) 
- Often includes occular lesions 
- mononeuritis multiplex
- 
Trt: with prednisone and cyclophosphamide

Question 15

1 cause of acquired Heart disease in kids

• mucocutaneous erythema, desquamation of fingertips, cervical adenopathy, conjunctivitis, rash
• coronary aneurysms 25%

Answer 15

• Kawasakis

- trt with ASA and IVIG

Question 16

Jaw claudication, elderly women, HA, Scandinavians, HIGH ESR (> 50)

Answer 16

Giant cell arteritis

• T cell infiltrate
• blindness complication: TRT on suspicion
• diagnosis ip with biopsy

Question 17

Myalgias without weakness, 50y/o + women, fever malaise et al

Answer 17

• polymyalgia rheumatica
• prednisone and cyclophosphamide
• angioplasty

Question 18

I can’t takya pulse

Answer 18

• takayasu’s