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Rheum > Vasculitis > Flashcards

Vasculitis Flashcards

1
Q

Three classic patterns of GCA presentation

A
  1. Cranial symptoms
  2. Large vessel/systemic presentation
  3. PMR
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2
Q

Two uncommon cranial symptoms of GCA

A

Tongue claudication and trismus

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3
Q

Autoimmune causes of aortitis (split in 2 categories)

A
  1. AI diseases:
    GCA
    TA
    Relpasong polychondritis
    Behchets
    Cogan
    SPA
  2. Outside
    Sarcoidosis
    IGG4
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4
Q

What % of GCA patients present only with constitutional symptoms

A

15-20

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5
Q

Three pathological mechanisms for blindness in GCA

A
  1. AION
  2. Retinal/ophthalmic artery occlusion
  3. Occipital stroke
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6
Q

Apart from blindness, what are the other visual manifestations of GCA

A
  1. Ophthalmoplegia —> diplopia —> 2/2 EOM ischemia
  2. Amaurosis fugax—> most predictive of future blindness
  3. Iritis
  4. Scotoma
  5. Glaucoma
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7
Q

Why do we not see intracranial involvement in GCA

A

Because the vessels lack and internal elastic lamina and vasa vasorum after enter the cranium

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8
Q

Which arterial involvement is unusual in GCA but can happen with Behchets as an isolated finding

A

Pulmonary

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9
Q

How do patients die from GCA

A
  1. Stroke
  2. MI
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10
Q

What is the time frame for highest mortality in GCA

A

First 4 months —> use aspirin to prevent MI or stroke

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11
Q

New non-IL-6 inhibitor for GCA

A

Mavrilimumab

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12
Q

What is the MOA of mavrilimumab

A

GM-CSF inhibitor

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13
Q

What is the RAVE TRAIL? Which disease and what was the major outcome

A

ANCA vasculitis —> showed non-inferiority of RTX over CYC

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14
Q

For ANCA vasculitis, which csDMARD can be used for induction therapy in non-severe ANCA vasculitis

A

MTX

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15
Q

What are the three csDMARDs used for maintainance in ANCA vasculitis

A

MTX, AZA, and MMF

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16
Q

Which CD20 antibody is used for (now as a standard of care) for maintainance in ANCA vasculitis

A

Rituximab —> used conventionally at 500 mg every 6 months but can be variable

17
Q

What is the PEXIVASC trail

A
18
Q

What is Avacopan?

A

C5aR1 inhibitor —> used in refractory GPA

19
Q

What is the duration of maintainance therapy in ANCA vasculitis

A

Unknown!!! What a surprise

20
Q

What is remission in ANCA vasculitis

A

We don’t know!! No wonder lol

21
Q

Which drugs can cause ANCA positivity

A
  1. Levimasole
  2. PTU
  3. Hydralazine
  4. Minocycline

Rheum (12 decks)

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