Vasculitides and Vaso-occlusive diseases Flashcards
what are the 4 CSVV
Henoch–Schönlein purpura
Acute hemorrhagic edema of infancy
Urticarial vasculitis
Erythema elevatum diutinum
what drugs can cuase CSVV
NSAIDs
COX-2 inhibitors
PCNs
quinolones
(also, ACEi, allopurinol, lasix)
how long after exposure to infection or drug does CSVV appear?
7-10 days
describe appearance of CSVV
palpable purpuric to erythematous papules, vesicles, and macules on lower extremities/dependent areas
urticaria that lasts > 24 hrs
urticarial vasculitis
labs in urticarial vasculitis
** majority w/o these findings (75%)
low complement levels
anti-C1q Ab
what is Schnitzerler’s syndrome
uritcarial vasculitis with monoclonal IgM gammopathy with at least 2 of the following
- fever
- arthralgias
- LAD
- HSM
- elevated ESR
- leukocytosis
- bone pain/abnormality
when you see urticarial vasculitis, think about
autoimmune connective tissue disease (SLE) infection (HBV, HCV, EBV) serum sickness malignancy meds (KI, NSAIDs, fluoxetine)
treatment of urticarial vasculitis
anti-histamines, NSAIDs, cholchicine, dapsone, antimalarials, oral steroids
sites of HSP lesions
lower ext and butt
other findings you can see with HSP
abdominal pain (colicky), GI bleeding, vomiting
arthritis
hematuria
**usu follows URI
histology + DIF of HSP
LCV perivascular IgA (and C3 and fibrin)
% HSP pts that can develop permanent renal dz
2%
describe lesions on EED
red, violaceous, brown papules and plques on extensor surfaces
what is EED a/w
autoimmune dz
infx (hemolytic strep, HBV, HIV)
IBD
IgA monoclonal gammopathy
treatment of EED
dapsone
what does EED stand for
erythema elevatum diutinum
describe lesions of granuloma faciale
smooth violaceous to re-brown plaque on face, usu solitary
tx for granuloma faciale
ILK, dapsone, tacrolimus
* often tx resistant
