Vasculitides and Vaso-occlusive diseases Flashcards
what are the 4 CSVV
Henoch–Schönlein purpura
Acute hemorrhagic edema of infancy
Urticarial vasculitis
Erythema elevatum diutinum
what drugs can cuase CSVV
NSAIDs
COX-2 inhibitors
PCNs
quinolones
(also, ACEi, allopurinol, lasix)
how long after exposure to infection or drug does CSVV appear?
7-10 days
describe appearance of CSVV
palpable purpuric to erythematous papules, vesicles, and macules on lower extremities/dependent areas
urticaria that lasts > 24 hrs
urticarial vasculitis
labs in urticarial vasculitis
** majority w/o these findings (75%)
low complement levels
anti-C1q Ab
what is Schnitzerler’s syndrome
uritcarial vasculitis with monoclonal IgM gammopathy with at least 2 of the following
- fever
- arthralgias
- LAD
- HSM
- elevated ESR
- leukocytosis
- bone pain/abnormality
when you see urticarial vasculitis, think about
autoimmune connective tissue disease (SLE) infection (HBV, HCV, EBV) serum sickness malignancy meds (KI, NSAIDs, fluoxetine)
treatment of urticarial vasculitis
anti-histamines, NSAIDs, cholchicine, dapsone, antimalarials, oral steroids
sites of HSP lesions
lower ext and butt
other findings you can see with HSP
abdominal pain (colicky), GI bleeding, vomiting
arthritis
hematuria
**usu follows URI
histology + DIF of HSP
LCV perivascular IgA (and C3 and fibrin)
% HSP pts that can develop permanent renal dz
2%
describe lesions on EED
red, violaceous, brown papules and plques on extensor surfaces
what is EED a/w
autoimmune dz
infx (hemolytic strep, HBV, HIV)
IBD
IgA monoclonal gammopathy
