Vasculitides

Question 1

What are the large vessel vasculitidies?

Answer 1

Temporal arteritis (giant cell arteritis)

Takayasu’s arteritis

Question 2

Temporal arteritis

Answer 2

Headache, eye pain/vision loss. Treat with steroids ASAP, then do temporal artery bx.

Question 3

Takayasu’s arteritis

Answer 3

Vasculitis of large vessels such as aorta. Leads to diminished peripheral pulses, hand claudication, discrepancies of BP readings. Classically in young Asian women. Tx: steroids, anti-HTN, surgery.

Question 4

What are the medium vessel vasculitides?

Answer 4

Kawasaki’s, GPA, EGPA, PAN

Question 5

Features of Kawasaki’s disease

Answer 5

Fever, conjunctivitis, stomatitis, rash, pericarditis/myocarditis. Tx with IVIG and aspirin!

Question 6

GPA stands for

Answer 6

Granulomatosis with polyangiitis (artist formerly known as Wegener’s)

Question 7

GPA features

Answer 7

ANCA-assoc GN, lung, sinus

Question 8

EGPA stands for

Answer 8

Eosinophilic granulomatosis with polyangiitis (artist formerly known as Churg-Strauss)

Question 9

EGPA

Answer 9

p-ANCA assoc GN, asthma, eosinophilia

Question 10

PAN stands for

Answer 10

Polyarteritis nodosa

Question 11

Polyarteritis nodosa

Answer 11

p-ANCA assoc GN, affects all organ systems except NO lung involvement. Assoc with Hep B

Question 12

What are the small vessel vasculitides?

Answer 12

Microscopic polyangiitis, Behceet’s, hypersensitivity vasculitis

Question 13

Microscopic polyangiitis

Answer 13

Affects kidney, skin, joints, lungs

Question 14

Behcet’s syndrome

Answer 14

Triad: oral apthous ulcers, genital ulcers, uveitis. Tx steroids

Question 15

Treatment for ANCA assoc vasculitides?

Answer 15

Steroids, cyclophosphamide, rituximab

Question 16

Buergers disease (thromboangiitis obliterans)

Answer 16

Classically in young male smokers. Causes ischemic claudication which can lead to gangrene. Must stop smoking!