Vasculitides Flashcards

1
Q

Define vasculitides

A

Primary vasculitides are classified based on MAIN VESSEL SIZE affected
- Large, medium, small

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2
Q

Define vasculitis

A

Inflammation & necrosis of blood vessels

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3
Q

Types of vasculitides - large vessel

2

A

Giant cell arteritis

Takayasu’s aortitis

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4
Q

Types of vasculitides - medium vessel

2

A

Polyarteritis nodosa

Kawasaki’s disease

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5
Q

Types of vasculitides - small vessel

6

A
Churg-Strauss syndrome
Microscopic polyangiitis 
Wegner’s granulomatosis
Henoch-Schonlein purpura
Mixed essential cryoglobinaemia (MEC)
Relapsing polychondritis
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6
Q

Aetiology of vasculitides

3

A

UNKNOWN
Suggested autoimmune origin
Immune complex deposition in the walls of blood vessels leads to inflammation

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7
Q

Risk factors for vasculitides

4

A

Hepatitis B - polyarteritis nodosa
Hepatitis C - mixed essential cryoglobinaemia
pANCA - microscopic polyangitis & Churg-Strauss
c-ANCA - Wegner’s granulomatosis

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8
Q

Epidemiology of vasculitides

prevalence, Takayasu group

A

RARE

Takayasu’s arteritis is most common in japanese females

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9
Q

Presenting symptoms & signs of vasculitides - general

2 general + 4

A

Large vessel vasculitides have a classic clinical pattern based on the vessels affected
Medium & small vessel vasculitides are characterised by multi organ involvement & have less specific clinical features

Fever
Malaise
Night sweats
Weight loss

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10
Q

Presenting symptoms & signs of vasculitides - skin

A

Rash

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11
Q

Presenting symptoms & signs of vasculitides - joint

2

A

Arthralgia

Arthritis

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12
Q

Presenting symptoms & signs of vasculitides - GI

3

A

Abdo pain
Haemorrhage
Diarrhoea

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13
Q

Presenting symptoms & signs of vasculitides - kidney

2

A

Glomerulonephritis

Renal failure

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14
Q

Presenting symptoms & signs of vasculitides - lungs

5

A
Dyspnoea
Cough
Chest pain
Haemoptysis
Haemorrhage
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15
Q

Presenting symptoms & signs of vasculitides - CVS

3

A

Pericarditis
Coronary arteritis
Myocarditis

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16
Q

Presenting symptoms & signs of vasculitides - CNS

2

A

Mononeuritis multiplex

Infarction

17
Q

Presenting symptoms & signs of vasculitides - eyes

2

A

Retinal haemorrhage

Cotton wool spots

18
Q

Presenting symptoms & signs of vasculitides - GCA

4

A

Loss of vision
Jaw claudication
Headache
Scalp tenderness

19
Q

Presenting symptoms & signs of vasculitides - polyarteritis nodosa
(5)

A
Micro aneurysms
Thrombosis 
Infarctions
Hypertension
Testicular pain
20
Q

Presenting symptoms & signs of vasculitides - Henoch-Schonlein purpura
(5)

A
Purpura
Arthritis
Gut symptoms 
Glomerulonephritis 
IgA deposition
21
Q

Presenting symptoms & signs of vasculitides - Wegner’s granulomatosis
(7)

A
Granulomatous vasculitis of upper & lower respiratory tract
Nasal discharge 
Ulceration & deformity
Haemoptysis 
Sinusitis
Glomerulonephritis 
Saddle nose
22
Q

Investigations for vasculitides

6 types

A

Bloods

Autoantibodies

Urine

CXR

Biopsy

Angiography

23
Q

Investigations for vasculitides - bloods

2

A

FBC - normocytic anaemia, high platelets, high neutrophils

High ESR/CRP

24
Q

Investigations for vasculitides - autoantibodies

A

e.g. cANCA in Wegner’s

25
Q

Investigations for vasculitides - urine

3

A

Haematuria
Proteinuria
Red cell casts (if glomerulonephritis)

26
Q

Investigations for vasculitides - CXR

2

A

Diffuse, nodular or flitting shadows

Atelectasis

27
Q

Investigations for vasculitides - biopsy

3

A

Renal
Lung
Temporal artery (in GCA)

28
Q

Investigations for vasculitides - angiography

A

To identify aneurysms (in PAN)