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Musculoskeletal > Systemic lupus erythematous (SLE) > Flashcards

Systemic lupus erythematous (SLE) Flashcards

1
Q

Define SLE

A

Multi system inflammatory autoimmune disorder

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2
Q

Diagnostic criteria for SLE

proportion + pneumonic

A

4/11 diagnostic criteria of American College of Rheumatology provides a high sensitivity & specificity for diagnosis of SLE

SOAP BRAIN MD

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3
Q

SOAP BRAIN MD

A

Serositis
Oral ulcers
Arthritis (non erosive)
Photosensitivity
Bloods (haemolytic anaemia/leukopenia/thrombocytopenia)
Renal disease (urine casts/proteinuria)
ANA
Immunological disorder (anti-dsDNA/anti-Sm/anti-phospholipid)
Neurological disease (pyschosis/seizures)
Malar rash
Discoid rash

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4
Q

Aetiology of SLE

3

A

UNKNOWN
Tissue damage may be caused by vascular immune complex deposition
Could be due to combination of hormonal, genetic & exogenous factors

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5
Q

Epidemiology of SLE

prevalence, age, ethnicity, gender

A

COMMON
More common in the young
More common in Afro-caribbean & Chinese
9x more common in FEMALES

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6
Q

Presenting symptoms & signs of SLE

5 general + 1, 1, 3

A 
Fever
Fatigue 
Weight loss
Lymphadenopathy
Splenomegaly
Raynaud’s phenomenon
Oral ulcers
Skin rash
- malar rash
- discoid lupus (red scaly patches)
- atypical rashes (e.g. photosensitivity, vasculitis, urticaria, purpura)
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7
Q

Presenting symptoms & signs of SLE - musculoskeletal

3

A

arthritis
tendonitis
myopathy

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8
Q

Presenting symptoms & signs of SLE - heart

4

A

pericarditis
myocarditis
arrhythmias
Libman-Sack endocarditis

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9
Q

Presenting symptoms & signs of SLE - lungs

4

A

pleurisy
pleural effusion
basal atelectasis
restrictive lung defects

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10
Q

Presenting symptoms & signs of SLE - neurological

5

A 
headache
confusion
stroke
cranial nerve palsies
chorea
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11
Q

Presenting symptoms & signs of SLE - psychiatric

2

A

depression

psychosis

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12
Q

Presenting symptoms & signs of SLE - renal

A

glomerulonephritis

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13
Q

Investigations for SLE

3 groups

A

Bloods
Autoantibodies
Others

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14
Q

Investigations for SLE - bloods

7

A 
FBC
U&Es
LFT
Raised ESR
Normal CRP
Clotting
Complement
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15
Q

Investigations for SLE - autoantibodies

9

A 
Anti-dsDNA (60%)
Rheumatoid factor (30-50%)
Anti-ENA
Anti-RNP
Anti-SM
Anti-Ro
Anti-La
Anti-histone
Anti-cardiolipin
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16
Q

Investigations for SLE - others

urine - 3

A

haematuria
proteinuria
red cell casts

17
Q

Investigations for SLE - others

joints

A

plain radiographs

18
Q

Investigations for SLE - others

heart & lungs - 4

A

CXR
ECG
echocardiogram
CT

19
Q

Investigations for SLE - others

kidneys

A

renal biopsy (if glomerulonephritis suspected)

20
Q

Investigations for SLE - others

CNS - 2

A

MRI

lumbar puncture

Musculoskeletal (20 decks)

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