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Dermpath Slide Study > Vascular Tumors > Flashcards

Vascular Tumors Flashcards

1
Q
A

Lymphangioma

“frog spawn”

D2-40 positive

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2
Q
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Angiokeratoma

“Bloody SK”

May have clot inside, acanthosis, hyperkeratosis, thin walled vessels

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3
Q
A

Nevus flammeus

Dilated capillary sized vessels

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4
Q
A

Angioma serpiginosum

Clinically looks like small dots on legs of female, bleed freely when traumatized

Histologically you see dilated tortuous capillaries in upper dermis

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5
Q
A

Venous lake

(usually collapses after biopsy)

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6
Q
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Glomus tumor

“string of black pearls”

commonly tender

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7
Q
A

Glomangioma

One to two layers of glomus cells around prominent vessels

More vessels than cells

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8
Q
A

Pyogenic granuloma

lobular capillary hemangioma

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9
Q
A

Bacillary angiomatosis

usually not distinctly lobular

Bartonella infection causes blood vessels to grow out of control and form tumor like masses

Look for amorphous clusters of organisms (+warthin starry) and +++neutrophils

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10
Q
A

Cherry angioma

Capillaries with pink hyalinization in walls

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11
Q
A

Infantile hemangioma

Tightly packed endothelial cells

RICH and NICH are glut 1 negative

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12
Q
A

Angiolymphoid hyperplasia with eos

Centrally you see thick walled vessels w/hobnail endothelium

Peripheral proliferation of smaller vessels and lymphoid nodular aggregates

Nodular aggregates of eos

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13
Q

What is angiolymphoid hyperplasia with eosinophilia aka?

A

Epithelioid Hemangioma

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14
Q
A

Kimura disease

Many deep lymphoid nodules

Many eosinophils with eosinophilic microabscesses

Presents as painless subQ swelling

Increased IgE

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15
Q
A

Intravascular papillary endothelial hyperplasia of Masson

*re-canalizing thrombus within a vascular space

papillary projections with hyalinized cores

Tx is cut it out (it can mimic malignancy)

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16
Q
A

AV malformation

Thin and thick walled vessels together

*compared to an angioma, there is no hyaline in walls

17
Q
A

Glomeruloid hemangioma

a/w Castleman dz and POEMS

polyneuropathy

organomegaly

endocrinopathy

M protein

skin findings

18
Q
A

Hobnail hemangioma

aka targetoid hemosiderotic hemangioma

*hemosiderin

Superficially you will see dilated vascular spaces, down deeper and on periphery more slit like with hemosiderin (mimicker of melanocytic lesion)

19
Q
A

Eccrine angiomatous hamartoma

Capillaries, mature eccrine glands, and ducts

DEEP hamartoma which is tender typically

20
Q
A

Microvenular hemangioma

small very flat vessels w/surrounding pericytes

bland and monomorphic appearing, spreads down deep

21
Q
A

Tufted angioma aka angioblastoma

“cannonball tufts” of capillaries in dermis

slowly growing plaque in child

22
Q
A

Myopericytoma

dermal nodule

whirled onion skin layers surrounding vascular channels

Myofibroma is mimicker

23
Q
A

PEComa

Perivascular endothelioid cell tumor

Very pale or clear cells around delicate vessels

+HMB45 (MelanA) but S100 is negative which helps to differentiate from Melanoma

24
Q
A

Kaposiform hemangioendothelioma

Soft tissue mass in infants almost always

many pts get kasabach merritt syndrome

Microscopically it looks limilar to tufted angioma or kaposi with slit like vessels but lobules are typically less well circumscribed, more infiltrative into surrounding tissue

25
PHAT Pleomorphic hyalinizing angiectatic tumor Pleo - spindled cells (can mimic schwannoma) \*PHAT is s100 negative, CD34 positive - helps to differentiate hyalinized or fibriboid vessel walls
26
Hemangiopericytoma Diffuse pericytes, staghorn vessels
27
Spindle cell hemangioma "Hemorrhagic lung" with alveolar spaces Spindled cells Pheloliths
28
Atypical vascular lesion
29
Angiosarcoma Atypical infiltrating connected vascular channels dissecting between collagen Hyperchromiatic atypical multilayered endothelial cells looking for c-MYC amplification via FISH can be helpful Can be epitheliod appearing as well
30
Epithelioid hemangioendothelioma Dilated vascular channels with solid epithelioid and spindle cell areas Intracytoplasmic lumens Variable pleomorphism and mitotic activity "Blister cells" are the small round vascular spaces noted here (its trying to make vascular spaces)
31
Retiform hemangioendothelioma Arborizing blood vessels reminiscent of rete testes considered a low grade angiosarcoma
32
Kaposi sarcoma, tumor stage Fairly circumscribed dermal nodule of spindled cells which form irregular slit like vascular spaces containing red blood cells "sieve-like" appearance with no true endothelial lining Cytologic atypia **+HHV8**, +CD34, CD31, ERG
33
Kaposi sarcoma, patch stage Subtle dermal proliferation of angulated thin walled slit like vessels **promontory sign: vessel wrapping around native structure** Extravasation of RBCs, hemosiderin deposition **+HHV8,** +CD34, +CD31

Dermpath Slide Study (26 decks)

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