Vascular smooth muscle contractility Flashcards
1
Q
why are the two types of smooth muscle organisation
A
mutiunitary and unitary
2
Q
what is the difference between the two organisations of smooth muscle
A
- Multiunit, where each cell receives innovation from autonomic neurons - allows for finer motor control
Unitary, where only some gets innovation from autonomic neurons, and is then spread via gap junctions
3
Q
what is the pump that uptakes calcium into the SR
A
SERCA (2a and 2b) pump
4
Q
what is the receptors that pushes calcium out of the SR
A
ryanodine receptors
IP3 receptors
5
Q
what are the two calcium binding proteins found inside the SR
A
calequestrine and calreticulin
6
Q
what is the molecule that calcium binds to when calcium is released, in terms of contractility
A
calmodulin –> Ca4-calmodulin
7
Q
what deactivates the phosphorylation of myosin light chain
A
myosin phosphorylase (NO and prostacyclin activates this molecule)
