Vascular Pharm

Question 1

General Classes that treat PAH

Answer 1

1) Prostanoids
2) Endothelial Antagonists
3) PDE5 Inhibitors
4) Riociguat (Sensitizer)

Question 2

MOA of Prostanoids

Answer 2

Increase cAMP –> vascular relaxation and suppresses vascular smooth muscle growth

Question 3

Prostanoids Effects

Answer 3

1) Lowers pulmonary arterial resistance
2) Decreases pulmonary arterial pressure
3) Increases exercise tolerance
4) Improves short term survival

Question 4

List Examples of Prostanoids

Answer 4

1) Treprostinil
2) Epoprostenol
3) Iloprost
4) Selexipag

Question 5

Treprostinil is an ____

Answer 5

Prostanoids

Question 6

Epoprostenol is a ___

Answer 6

Prostanoids

Question 7

Iloprost Is an ___

Answer 7

Prostanoids

Question 8

Selexipag is an ___

Answer 8

Prostanoids

Question 9

Which two prostanoids can cause sepsis due to chronic catheter

Answer 9

1) Treprostinil

2) Epoprostenol

Question 10

Epoprostenol needs to be ____ unlike Treprostinil

Answer 10

Refrigerated

Question 11

Common side effects to all Prostanoids

Answer 11

1) Headache
2) Flushing
3) N/V/D
4) Jaw Pain
5) Skin Rash

Question 12

Iloprost can cause ___

Answer 12

Hypotension

Question 13

Selexipag can be used ____ if IV is refused or treating a child

Answer 13

orally

Question 14

MOA of Endothelin Antagonist

Answer 14

1) Nonspecifically blocks Eta and Etb endothelin receptors

Question 15

Effects of endothelin antagonist

Answer 15

1) Improves Exercise Tolerance

2) Slows sx progression

Question 16

Examples of endothelin Antagonists

Answer 16

1) Ambrisentan - Eta selective

2) Macitentan - Nonselective

Question 17

Ambrisentan if used in preg causes

Answer 17

Teratogenesis

Question 18

Macitentan is an

Answer 18

Endothelin Antagonist

Question 19

Ambrisentan is an

Answer 19

Endothelin Antagonist

Question 20

Sildenafil is an

Answer 20

PDE5 inhibitor

Question 21

Riociguat shouldnt be used during

Answer 21

Pregnancy