Asthma and COPD Drugs

Question 1

List the SABAs

Answer 1

1) Albuterol
2) Terbutaline
3) Metaproterenol
4) Pirbuterol
5) Levalbuterol

Question 2

MOA/Effects SABA

Answer 2

1) Increase AC generation
- Reverse Bronchoconstriction
- Relax airway smooth muscle

Question 3

Which of the SABAs is a Sulfa

Answer 3

Terbutaline

Question 4

Which of the SABAs can cause Cardiac Adverse Effects

Answer 4

Pirbuterol

Question 5

List the ICS

Answer 5

1) Beclomethasone
2) Budesonide
3) Ciclesonide
4) Flunisolide
5) Fluticasone
6) Mometasone
7) Triamcinolone

Question 6

Budesonide and mometasone cannot be used if pt has

Answer 6

milk allergy

Question 7

Which ICS is least likely to cause candida

Answer 7

ciclesonide

Question 8

List the Oral and Parenteral Corticosteroid

Answer 8

Prednisone

Question 9

When should you use LABA in asthma

Answer 9

Only with ICS

Question 10

LABAs Adverse effects for asthma

Answer 10

Increase risk of asthma-related deaths and asthma-related hospitalizations

Question 11

List examples of LABA

Answer 11

1) Fomoterol
2) Salmeterol
3) Indacaterol and Vilanterol
4) Olodaterol

Question 12

Fomoterol is an

Answer 12

LABA

Question 13

Falmeterol is an

Answer 13

LABA

Question 14

Indacaterol and Vilanterol are

Answer 14

LABAs

Question 15

Olodaterol is an

Answer 15

LABA

Question 16

Which LABA is a long-term, once-daily maintence bronchodilator for airflow obstruction

Answer 16

Olodaterol

Question 17

LAMAs MOA

Answer 17

1) Block Acetylcholine from binding

2) Inhibit parasympathetic nerve impulses

Question 18

LAMA Examples

Answer 18

1) Atropine - Temp Blockade
2) Ipratropium - Maintenance
3) Tiotropium - LT Maintenance
4) Aclidinium - LT Maintenance

Question 19

Atropine is an

Answer 19

LAMA

Question 20

Ipratropium is an

Answer 20

LAMA

Question 21

Tiotropium is an

Answer 21

LAMA

Question 22

Aclidinium is an

Answer 22

LAMA

Question 23

Methylxanthines MOA

Answer 23

Inhibit PDE

Inhibit Bronchoconstriction

Question 24

Exacerbations of Methylxanthines

Answer 24

1) PUD
2) Seizure Disorders
3) Cardiac Arrhythmias

Question 25

Omalizumab is an

Answer 25

Monocloncal Antibody that binds to IgE

Question 26

List the Leukotriene Receptor Antagonists/Lipoxygenase Inhibitors

Answer 26

1) Montelukast
2) Zafirlukast
3) Zileuton-controlled release

Question 27

Effects of Leukotriene Receptor Antagonists/Lipoxygenase Inhibitors

Answer 27

1) Anti-inflammatory

2) Glucocorticoid sparing effect

Question 28

Indication of Leukotriene Receptor Antagonists/Lipoxygenase Inhibitors

Answer 28

1) Treatment and prevention of acute asthmatic attacks

Question 29

MOA of Motelukast

Answer 29

Inhibits LTD4 at CysLT1 receptor w.o any agonist activity

Question 30

Indication of Montelukast

Answer 30

1) Allergies

2) Prevent Asthma Attacks

Question 31

Can you use Montelukast to treat active attacks

Answer 31

NO

Question 32

MOA of Zafirlukast

Answer 32

Inhibits LTD4 and LTE4 receptor

Question 33

Indication of Zafirlukast

Answer 33

Prophylaxis and Chronic asthma treatment

Question 34

Zileuton-Controlled Release MOA

Answer 34

5-lipoxygenase inhibitor –> inhibition of LTB4, LTC4, and LTD4

Question 35

Indication of Zileuton Controlled release

Answer 35

Prophylaxis and Chronic Treatment of Asthma

Question 36

Caution for Zafirlukast

Answer 36

Hepatotoxicity

Question 37

Caution for Zileuton-Controlled Release

Answer 37

NOT recommended in cases where active liver disase or hepatic function elevations are >/= 3 times upper limit

Question 38

Caution of Omalizumab

Answer 38

Anaphylaxis (NEED to observe pt for an amount of time)

Question 39

Indication of Omalizumab

Answer 39

1) Moderate and Severe Persistent Asthma w/ + skin test or in vitro reactivity to perennial aearoallergen
2) Chronic Idiopathic urticaria

Question 40

Which LAMA is relatively free of systemic atropine like effects

Answer 40

IPRATROPIUM