Vascular Embryology: Topic 7 Flashcards
Vascular development occurs by what two mechanisms?
Vasculogenesis
Angiogenesis
Vasculogenesis
Coalescence of angioblasts
i.e. Major vessels such as the dorsal aorta and cardinal veins
Angiogenesis
Vessels sprout from existing vessels
I.e. remainder of vascular system
What leads to enlargement of some vessels while other vessels are obliterated?
Preferential flow related to the development of organs
How does enlargement of vessels occur?
By way of fusion with smaller vessels and partly by enlargement of individual capillary beds
What are the major arterial conduits in the early embryo?
Dorsal aortas
What is simply a continuation of the endocardial tubes?
Dorsal aortas
Where do dorsal aortas arise from?
Aortic sac (distal most part of the truncus arteriosus)
What establishes the first pair of aortic arches?
Because of the changing position of the developing heart tube and pericardium, the cranial portions of the dorsal aortas come to describe an arc on both sides of the foregut
How many pairs of aortic arches are present at some point during development?
6 pairs
What is the only transient aortic arch?
5th aortic arch
What is notable about the 5th aortic arch?
It never forms or forms incompletely and regresses
How are the aortic arches numbered?
I, II, III, IV, VI
What happens to the arches as they develop?
Some become modified and others regress
At day 27, the aortic arch I has largely disappeared. Part of it remains and becomes what?
Maxillary Artery
Remnant of Arch II becomes what?
Stapedial Artery
Aortic arches IV and VI are being formed as what?
Ventral and dorsal sprouts
What does Arch III form?
Common carotid artery and first part of the internal carotid artery
What does Arch IV become?
Left Arch IV
Right Arch IV
Left Arch IV
part of the aortic arch between LCC and L. Subclavian