Vascular Disorders

Question 1

Familial chylomicronemia (type I)

Answer 1

• LPL or apoCII deficiency
• CM and, later, VLDL increase
• High serum TG w/ turbid supranate and clear infranate
• Acute pancreatitis

Question 2

Type II hyperlipidemia

Answer 2

• Increased serum CH and LDL

* Hypothyroidism, blocked bile flow, nephrotic syndrome, genetic (familial hypercholesterolemia)

Question 3

Familial dysbetalipoproteinemia (type III)

Answer 3

• ApoE deficiency; decreased IDL and CM remnant uptake
• Increased serum CH and TG, normal-high LDL
• Palmar xanthomas

Question 4

Type IV hyperlipidemia

Answer 4

• Increased VLDL
• EtOH, OCP, DM, renal failure, diuretic use, genetic (familial hypertriglyceridemia)
• Increased TG, normal-high CH and LDL, decreased HDL
• Eruptive xanthomas

Question 5

Type V hyperlipidemia

Answer 5

• Genetic
• Decreased LPL —> increased CMs and VLDL
• Increased TG, normal CH and LDL
• Eruptive xanthomas, acute pancreatitis, lipemia retinalis, dyspnea, hypoxemia, hepatosplenomegaly