Vascular and Platelet disorders Flashcards
Also known as Moschowitz syndrome
a. Thrombotic Thrombocytopenic Purpura
b. Post Transfusion Purpura
c. Non-Immune Destruction of Platelets
Thrombotic Thrombocytopenic Purpura (TTP)
deficiency in ADAMTS 13 and formation of hyaline thrombin in cappilaries and arterioles throughout the body
a. Thrombotic Thrombocytopenic Purpura
b. Post Transfusion Purpura
c. Non-Immune Destruction of Platelets
Thrombotic Thrombocytopenic Purpura
(TTP)
rapid onset of severe thrombocytopenia
life threatening hemorrhage
treatment: IVIg
a. Thrombotic Thrombocytopenic Purpura
b. Post Transfusion Purpura
c. Non-Immune Destruction of Platelets
Post Transfusion Purpura
occurs in children after GIT infection.
toxins enter bloodstream and attaches to renal glomerular cells.
a. Hemolytic Uremic Syndrome
b. Post Transfusion Purpura
c. Non-Immune Destruction of Platelets
a. Hemolytic Uremic Syndrome
b. Post Transfusion Purpura
c. Non-Immune Destruction of Platelets
HELLP syndrome
a. Hemolytic Uremic Syndrome
b. Post Transfusion Purpura
c. Thrombocytopenia in Pregnancy and Preeclampsia
a. Hemolytic Uremic Syndrome
b. Post Transfusion Purpura
c. Thrombocytopenia in Pregnancy and Preeclampsia
Treatment for Thrombocytopenia in Pregnancy and Preeclampsia
a. Discontinue use
b. Delivery of infant whenever possible
c. Washed Maternal Cells
a. Discontinue use
b. Delivery of infant whenever possible
c. Washed Maternal Cells
erythrocyte destruction is antibody mediated
a. Hemolytic Uremic Syndrome
b. Hemolytic Disease of Fetus and Newborn
c. Thrombocytopenia in Pregnancy and Preeclampsia
a. Hemolytic Uremic Syndrome
b. Hemolytic Disease of Fetus and Newborn
c. Thrombocytopenia in Pregnancy and Preeclampsia
Abxicimab, Tirofiban, Eftifibadite, Quinidine
a. Drug-dependent Ab
b. Hapten-induced Ab
c. Drug-induced Ab
a. Drug-dependent Ab
b. Hapten-induced Ab
c. Drug-induced Ab
small drug molecules combine with plasma. severe thrombocytopenia.
a. Drug-dependent Ab
b. Hapten-induced Ab
c. Drug-induced Ab
Hapten-induced Ab
Antibody production when exposed to drug
a. Immunologic Drug-induced Thrombocytopenia
b. Hemolytic Disease of Fetus and Newborn
c. Non-Immune Destruction of Platelets
Immunologic Drug-induced Thrombocytopenia
In Increased Platelet Destruction, what are IMMUNOLOGIC diseases?
Drug-induced
Neonatal Autoimmune
Post Transfusion Purpura
ITP
NAIT
Normal to increased megakaryocytes but decreased circulating platelets. Defective platelet formation or destruction of platelets in the BM.
a. Ineffective Thrombopoeisis
b. Increased Destruction
c. Abnormal distribution or dilution
a. Ineffective Thrombopoeisis
b. Increased Destruction
c. Abnormal distribution or dilution
