Vascular Flashcards

1
Q

Etiology of peripheral arterial disease

A

Atherosclerosis

Differentials:
Beurger disease - thromboangiitis obliterans
vasculitis - takayasu arteritis, bechet disease
ergot toxicity
vasospasm
Cystic medial degeneration
Popliteal artery aneurysm - showering of emboli
Fibromyalgia dysplasia

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2
Q

Diagnostic criteria of critical limb ischemia

A
  1. rest pain req opioid analgesia
  2. tissue loss - ulcer, gangrene
  3. ABI<0.5, TPI<0.3, Toe pressure<30, Ankle pressure<50
    for more than 2 weeks
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3
Q

Classification for acute limb ischemia

A
Rutherford classification
I: viable
II: threatened (a: marginally, 
image and revasc urgently
b:immediately) - emergency revasc
III: Irreversible, non viable - amputation

Sensory, motor, doppler - arterial and venous

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4
Q

Classification of chronic limb ischemia

A

Fontaine or Rutherford

0 - asymptomatic
1 - mild claud
2- mod claud
3- maj claud
4 - rest pain
5 - minor tissue loss
6 - major tissue loss (more than forefoot)
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5
Q

Investigations for PAD

A

Anatomical

  • arterial duplex (us)
  • CT angiogram
  • lesser used: bone subtraction angiogram, MRA

Perfusion
- ABPI/ TBI

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6
Q

Management of PAD

A

Asymptomatic

  • lifestyle
  • manage various RF (smoking, HTN, DM - HbA1c)
  • statins, single anti pat therapy

Claudicants, non debilitating

  • supervised exercise therapy (30m, 3x/7, for 12w)
  • drugs: naftidrofurul, cilostazol

Claudicants, debilitating; critical limb ischemia:
revascularisation (endoscopic angioplasty/ stenting, subintimal angioplasty vs bypass) - Transatlantic classification

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7
Q

Buerger’s test

A

significant if pallor when raised <20 deg
venous guttering

reactive hyperaemia when foot placed down from bed

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8
Q

What is a positive exercise test

A

fall of ABI >0.2 post exercise

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9
Q

When to repair AAA

A

Asymptomatic: threshold 5.5cm (follow up with u/s) - give statin to slow rate of growth
or >1cm/year or saccular aneurysm (rather than fusiform)
AND patient fit for surgery

Symptomatic: repair ASAP regardless of size - pain or distal embolisation
(optimise for surgery - CVS fx)

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10
Q

Criteria for AAA

A

Normal Aorta: 2-2.5cm
AAA: >3
Aortic diameter>50% than normal
<50%: ectasia

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11
Q

RF AAA
and
RF for rupture

A

smoking
male
family hx
disorders: marfan (fibrillin 1), Ehler danlos syndrome IV (type 3 collagen)
others: HTN, HLD, atherosclerosis, advanced age, hyperhomocysteinemia

RF for rupture:
COPD, smoking, larger initial AAA size, female gender, renal transplant, rate of enlargement

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12
Q

Types of rAAA presentation

A
  1. Classical: hypotension, shock, pain rad to back, pulsatile ab mass
  2. Local contained: radicular symptoms to thigh, groin with GI/urinary obstruction
  3. rupture into IVC (aortocaval fistula): audible ab bruit, venous HTN (swollen cyanotic legs, lower GI bleed, hematuria)
  4. distal embolisation (thrash foot)
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13
Q

Cx of AAA surgery

A

Intra-op: haemorrhage, distal embolisation (thrash), distal limb arterial thrombosis

Early: spinal cord ischemia (paralysis), ARF (oliguria), AMI, CVA, acute sigmoid colon ischemia, pneumonia, ARDS

Late: aortoenteric fistula, graft infection (Dacron graft), false aneurysm formation, sexual dysfunction, renal failure

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14
Q

Endovascular (EVAR) vs open AAA sx repair

A

Short term: endo mortality rate lower, and a/w lower aneurysm relate death

LT (4 y): endo has higher incidence of post op cx and need for re-intervention

endo needs long term follow up with CT angio to check position of stent

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15
Q

Position of SFJ

A

2.5cm inferolateral to pubic tubercle

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16
Q

How to confirm it is saphena varix

A

located at SFJ/ inguinal region, soft, compressible

collapsible when lying down, positive cough impulse

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17
Q

grading of chronic venous insufficiency

A
CEAP classification
0 - normal
1 - telangiectasia (<1mm), reticular veins (1-3mm)
2 - varicose veins (>3mm)
3 - edema 
4 a venous eczema/ hyperpigmentation
4 b atrophie blanche, lipodermatosclerosis
5 - healed ulcer
6 - active venous ulcer
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18
Q

Venous ulcer management

A

first rule out marjolin cancer - biopsy

Conservative: 4 layer compression bandage

  • first ensure ABI >0.8
    1. non stick wound dressing + wool bandage
    2. crepe bandage
    3. blue line bandage (elset)
    4. adhesive bandage (coban)
  • aim ankle pressure ~30mmhg
  • also give: analgesia, antibiotics (if infx), avoid trauma, elevate legs when resting, compression stockings for life after healed

Surgical: split skin graft, venous sx for underlying pathology

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19
Q

Varicose veins management

- cx of surgery

A

Conservative:

  • lifestyle: change job, avoid standing long durations
  • daflon
  • graduated compression stockings

Surgical if: 1. cosmesis, 2. symptomatic, 3. cx

  • high tie with GSV stripping - stab avulsion (CI if DVT)
    (cx: DVT , saphenous nerve injury)
  • US guided injection foam sclerotherapy
    (cx: cutaneous necrosis, hyperpigmentation, telangiectasic matting, thrombophlebitis, allergic reaction, venous
    thromboembolism)
  • endovenous laser/ radiotherapy saphenous vein ablation
    (cx: skin burns, DVT, PE, vein perforation & hematoma, superficial thrombophlebitis)
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20
Q

Anatomical relations of GSV, SSV

A

GSV: passes anterior to medial malleolus, travel with saphenous nerve

SSV: passes posterior to posterior malleolus, travel with sural nerve

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21
Q

Special tests for venous PE

A

tourniquet test, trendelenburg test, perthes test, doppler ultrasound

22
Q

arterial supply of LL

A

aorta > common iliac > int/ext iliac > common femoral

5 br: sup epigastric, sup circumflex art, sup ext pudendal art, deep ext pud art, profunda femoris (3 br: med/lat circumflex fem art, 4 perforating branches)

pop>ant/pos tibial, peroneal arteries

23
Q

Description of dorsalis pedis

A

one third of the way down a line joining the midpoint of the two malleoli to the cleft between the first and second toe located between the extensor halluces longus and extensor digitorium longus

24
Q

location of claudication vs site of dz

  • buttock
  • thigh
  • calf
  • foot
A

buttock/ impotence: stenosis of lower aorta/ common iliac (aortoiliac dz)

thigh: ext iliac, common fem, aortoiliac dz
calf: superficial femoral (femoral-popliteal dz)
foot: tibial peroneal dz

25
Q

Arterial exam

  • inspection
  • palpation
  • special
A

Inspect:

  • colour (red, white, purple)
  • trophic changes: hairless, dry shiny skin, thickened nail
  • tissue loss: ulcer/ gangrene/ amputation
  • surrounding skin: cellulitis, nec fas, DM dermopathy
  • deformities: Charcot

Feel:

  • temp, CRT, bogginess, discharge, inguinal LN
  • pulses grading

Special: beurger
Complete:
- full neuro LL exam: sensory, motor, peripheral neuropathy
- palpate other peri pulses, auscultate for bruit
- ab for AAA
- ABPI
- neck for carotid art stenosis

26
Q

Differentiate between art, venous and neuropathic ulcers

A

pain: ischemic painful
site: distal toes, lat malleolus/ gaiter, medial malleolus/ heel,MT heads
size: vary/ large/ -
shape: defined/ irregular/ punched
edge: punched/ sloping/ clean
base: no gran/ gran
surrounding skin: pale/ venous signs/ normal
temp: cold/ warm/ dry
pulses: absent for art
sensation/reflex/ vibration: loss in neuropathic
bone: in neuro

27
Q

types of amputations

A

ray, forefoot, lisfranc (trans MT), Chopard (mid-tarsal), syme (thru ankle), BKA, AKA, through knee, hip disarticulation

28
Q

ABPI values

TPI values

A

ABPI
N: >0.9
occlusion: 0.5-0.9
non comp calcified vessel: >1.4

TBI
abN: <0.7

29
Q

lab Ix to do for asymptomatic patients to check risk of developing PAD

A

CRP

30
Q

Best medical therapy for PAD

A
smoking cessation (bupropion)
weight reduction
LDL < 2.6, high risk<1.8 (statin)
Hba1c<7%, podiatrist
BP<140/90, <130/80 if DM or renal dz - ACEi
SAPT - clopidogrel 75mg > aspirin 100mg
31
Q

Indications for amputation

A

4Ds: dead (ischemic), damaged (trauma), dangerous (gangrene, sepsis, Ca), damn nuisance (infx, neuropathy)

32
Q

Complications of amputation

A
Early:
- hematoma, wound infx (gas gangrene)
- DVT, PE
- phantom limb pain
- skin necrosis (poor perfusion of stump > refashioning)
- psychological/social coping
Late
- OM
- stump ulceration
- stump neuroma
- fixed flexion deformity
- difficulty mobilising
- spurs and osteophytes in underlying bone
33
Q

ddx for acute limb ischemia

A

acute DVT: phegmasia cerulean dolens
blue toe syndrome: atheroembolism from AAA
purple toe syndrome: cx of wafarin
venous insufficiency

34
Q

Causes of acute limb ischemia

A
arterial embolism
- cardiac: AF, recent AMI with LV mural thrombus, prosthetic heart valves
- non cardiac
acute thrombosis
- atherosclerosis
- hypercoag states: APS, HIT
- medium vessel vasculitis
arterial trauma
dissecting aortic aneurysm
35
Q

6Ps of acute limb ischemia

A

pain, paresthesia, pallor (mottled, duskiness, black), pulseless, paralysis, perishingly cold (heavy limb, intrinsic foot muscles > leg muscles)

paresthesia progression: light touch > V >P > deep pain> pressure sense

36
Q

LeRiche Syndrome

A

occlusion at bifurcation of terminal aorta

tetrad: buttock claud + impotence in men + absent femoral and distal pulses + aortoiliac bruits

37
Q

Ls of PAD

A

Life > Limb > Lifestyle

38
Q

Embolic vs thrombotic cause of acute limb ischemia

A

source, claud hx, PE, angio

EMBOLIC: source present - AF, AMI, no claud hx, pale white leg, contra pulses present, no collaterals on angio, sharp cut off, minimal atherosclerosis

THROMBOTIC: no source, claud hx, dusky, contra leg pulses diminished, angio - diffuse atherosclerosis, collaterals well formed, irregular cut off

39
Q

Management of Acute Limb Ischemia

A
  1. Doppler to determine severity via Rutherford Classification
  2. Prep for op: op bloods, ECG, CXR, call OT, call vascular surgeon
  3. Early coagulation: IV heparin bolus 70unit/kg, then infusion 15unit/kg/hr - maintain PTT 50-75s (2-2.5x normal)
  4. improve existing perfusion: dependent position, avoid injuries, heel pressure, extremes of temp, 100%O2, correct hypotension
  5. surgical emergency (+- fasiotomy) w on table angiogram (confirm occlusion, determine cause - thrombotic vs embolic, level of occlusion, anatomy)
  6. Post op anti coag w heparin and vasodilators if vasospasm
  7. mg risk factors (e.g AF)
40
Q

Surgical options for limb salvage

A
Open surgical
- embolectomy/ thrombectomy
- endarterectomy
- bypass grafting
- fasciotomy
- primary amputation
Endovascular
- thrombolysis
- angioplasty
- stenting
41
Q

Intra arterial catheter directed thrombolysis

  • how it works
  • contraindications
A

thrombolysis catheter into clot, infuse TPA (alteplase) for 6 hours (in HD) - angioplasty and stent after

Contraindications
Absolute
􏰀- CVA within past 2 months
􏰀- Active bleeding / recent BGIT past 10 days
􏰀- Intracranial haemorrhage/ vascular brain neoplasm/ neuroSx past 3 months

Relative
􏰀- CPR past 10 days
􏰀- Major Sx / trauma past 10 days
- 􏰀Uncontrolled HTN

42
Q

Complications of limb salvage

A
  1. Reperfusion injury
  2. Rhabdomyolysis > (release K, lactic acid, myoglobin, ) hyperkalemia - arrhythmias
    tx: hydrate + IV bicarb to alkalinise urine
  3. Compartment syndrome (>30mmhg or within 30 of DBP) - 4 compartment fasciotomy
43
Q

Differentials for ischemic rest pain

A
  • Diabetic Neuropathy
  • Complex Regional Pain Syndrome
  • Nerve Root Compression
  • Peripheral Sensory Neuropathy (other than diabetic neuropathy) - Night Cramps
  • Buerger‟s Disease (thromboangitis obliterans)
44
Q

locations of communicating veins

A
  • SFJunction (GSV into fem vein)
  • Hunterian perforator: mid-thigh
  • Dodd‟s perforator: distal thigh
  • Boyd‟s perforator: knee
  • Cockett (posterior tibial) perforators: at 5, 10, and 15 cm above the medial malleolus (connects posterior arch vein to posterior tibial vein)
45
Q

Complications of AV access

A

Mechanical
- Stenosis
- thrombosis
- infx (S aureus)
- aneurysm - rupture, bleeding, ulceration
Functional
- arterial steal syndrome (ischemic pain, neuropathy, ulceration/gangrene)
- venous HTN (skin discolouration, hyperpigmentation, ulceration)
- CCF (increased venous return)
- failure of fistula, graft

46
Q

AV graft

  • advantages
  • disadvantages
A
  • large surface area
  • easy cannulation
  • short maturation time (3-6w)
  • easy surgical handling
47
Q

AV fistula

  • types
  • advantages
  • disadvantages
  • suitability
  • how to prepare
A
  • Brachio-cephalic, Radio-cephalic, Brachio-Basilic
  • long term patency, low infx risk, high blood flow rate, least likely to clot, less arterial steal syndrome
  • long maturation time
  • presence of vein diameter >4mm (more likely to succeed)
  • Prep: avoid blood taking, venipuncture, tight clothing
48
Q

AV fistula assessment - rule of 6

A

at 6 w post creation, diameter of fistula body>6mm
depth no more than 0.6cm
blood flow rate >600ml/min
length of fistula 6cm

occlusion of outflow: augmentation of pulse (adequate inflow)

raise arm above heart should collapse fistula (adequate drainage)

Doppler us

49
Q

Fistula failure definition

A

fistula that never matured to be useful
difficult to cannulate
not enough blood flow for successful 2 needle dialysis

50
Q

types of aneurysms

A
Congenital: berry
Acquired:
- atheromatous (ab, pop, fem)
- mycotic (subacute IE)
- syphilitic (thoracic)
- dissecting (cx: inferior MI, AR)
- false
- arteriovenous