Valve Disease Flashcards

1
Q

what is the structure of the aortic valve?

A

3 leaflets - left, right and posterior

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2
Q

when does the aortic valve open?

A

systole

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3
Q

when does the aortic valve close?

A

diastole

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4
Q

what happens to a valve in stenosis?

A

doesn’t open all the way

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5
Q

what happens to a valve in regurgitation?

A

doesn’t close all the way

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6
Q

how far does the aortic valve open in stenosis compared to normal

A

<1cm vs 3-4cm

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7
Q

what is the pathophysiology of aortic stenosis?

A

Mechanical stress or repeated inflammation over time which damages endothelial cells around the valves causing fibrosis an calcification
Valves become stiff and can’t open as easy

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8
Q

what is the impact on the heart in aortic stenosis?

A

left ventricle has to generate higher pressure to get same amount of blood through valve, undergoes hypertrophy

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9
Q

what causes the murmur in aortic stenosis?

A

• Since the blood has to flow though a narrow opening theres turbulence which creates a noise or a murmur which initially gets louder as more blood passes through the opening and then quitter as the amount of blood flowing subsides because less remains in the ventricle

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10
Q

what are the causes of aortic stenosis?

A

Congenital - bicuspid valve, Williams syndrome
Senile Calcification
Age
Chronic Rheumatic Fever

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11
Q

what murmur is heard in aortic stenosis?

A

Ejection Systolic murmur

crescendo-descendo murmur

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12
Q

what other clinical features are present in aortic stenosis?

A
Syncope, dyspnoea, fatigue 
Slow rising pulse with narrow pulse pressure difference
Heave - apex beat not displaced
Signs of HF
AF 
Angina
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13
Q

what three investigations can be done for aortic stenosis?

A

ECG, doppler echo, cardiac catheterisation

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14
Q

what features are present in the ECG of someone with aortic stenosis?

A

o L – LBBB – due do calcification
o L – Left Axis Deviation
o L – LVH
o P – Poor R wave progression (i.e. depolarisation of the ventricles is slow)

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15
Q

what are the pressures of the different types of aortic stenosis?

A

o 0 mmHg – normal valve
o <30 mmHg – mild aortic stenosis
o 30-50 mmHg – moderate aortic stenosis
o >50 mmHg – severe aortic stenosis

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16
Q

what is the management of aortic stenosis?

A

valve replacement (prosthetic or metal)

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17
Q

What are the complications associated with aortic stenosis?

A

HF, Microangiopathic haemolytic anaemia

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18
Q

What are the acute causes of aortic regurgitation?

A

infective endocarditis, ascending aortic dissection, chest trauma

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19
Q

what are the chronic causes of aortic regurgitation?

A

congenital, connective tissue dsorders (marfaans, ehlers-danlos), rheumatic fever, Takayasu arteritis, rheumatoid arthritis, SLe, pseudoxanthoma elasticum, appetite suppressants, seronegative arthroceles (ankylosing spondylitis, reiters syndrome, psoriatic arthropathic), hypertension, osteogenesis imperfecta, syphilitic aortitis

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20
Q

what is a common cause of aortic regurgitation?

A

aortic root dilation

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21
Q

what is the mechanism of aortic regurgitation?

A

valve does not close properly causing blood to flow back from the aorta into the left ventricle during diastole or ventricular filling

22
Q

what causes the murmur heard in aortic regurgitation

A

early decrescendo murmur caused by the flood flowing back through the valve

23
Q

what are the two consequences of aortic regurgitation?

A

Hyperdynamic circulation

Eccentric Ventricular Hypertrophy

24
Q

How does aortic regurgitation cause hyperdynamic circulation?

A
  • Systole more blood pumped out of the heart requires more pressure, so systolic blood pressure increases
  • Diastole if theres less blood volume in the aorta as some leaks back down, which means diastolic BP decreased
  • A higher systolic BP and lower diastolic BP means an increase in pulse pressure
25
Q

How does aortic regurgitation cause ventricular hypertrophy?

A

Since the bloods leaking back into the left ventricle, the left ventricular blood volume increases which increases the stroke volume

26
Q

what murmur is heard in aortic regurgitation?

A

mid-systolic flow murmur with additional diastolic sound

Radiates to neck?

27
Q

what other signs can be present in aortic regurgitation?

A
  • Corrigans sign – carotid pulsation
  • De Mussets sign – head nodding with heart beat
  • Quinkes signs – capillary bed pulsation
  • Duroziezs sign – compressing femoral artery causes murmur
  • Traubes – pistol shot sound over femoral arteries
28
Q

what investigations can be done for aortic regurgitation?

A
ECG
LVH
CXR: cardiomegaly, dilatated ascending aorta, pulmonary oedema
Echo – diagnostic
Cardiac catherization
29
Q

what investigations can be done for aortic regurgitation?

A
ECG
LVH
CXR
Echo 
Cardiac catherization
30
Q

what is the treatment for aortic regurgitation?

A

valve replacement

31
Q

what features will be seen on CXR of someone with aortic regurgitation

A

cardiomegaly, dilatated ascending aorta, pulmonary oedema

32
Q

which investigation is diagnostic in aortic regurgitation?

A

echo

33
Q

what are the causes of tricuspid regurgitation

A
  • Functional: RV dilation e.g. due to pulmonary hypertension induced by LV failure
  • Rheumatic fever
  • Infective endocarditis
  • Carcinoid syndrome
  • Congenital (e.g. ASV, AV canal, ebsteins anomaly
  • Drugs (ergot-derived dopamine agonists
34
Q

what murmur is heard in tricuspid regurgitation?

A

• Pansystolic murmur heard best at lower sternal edge in inspiration

35
Q

What clinical features are present in tricuspid regurgitation?

A

Fatigue, Ascites, Oedema
Dunspnoea and orthopnoea if LV
Giant V waves and prominent y descent in JVP
RV heave
Liver pain, pulsatile hepatomegaly, jaundice

36
Q

what is the management of tricuspid regurgitation?

A

valve replacement

37
Q

what is the cause of tricuspid stenosis?

A
  • Rheumatic fever

* Also congenital, infective endocarditis

38
Q

what are the clinical features of tricuspid stenosis?

A

Fatigue, Ascites, Oedema
Giant a wave and slow y descent in JVP
Opening snap
AF

39
Q

what is the management of tricuspid stenosis?

A
  • Diuretics

* Surgical repair

40
Q

what murmur is heard in tricuspid stenosis?

A

early diastolic murmur heard at left sternal edge in inspiration

41
Q

what are the congenital causes of pulmonary stenosis?

A

turners, noonans, Williams, Fallots, rubella

42
Q

what are the acquired causes of pulmonary stenosis?

A

rheumatic fever, carcinoid syndrome

43
Q

what murmur is heard in pulmonary stenosis

A

ejection systolic murmur (radiates down left shoulder)

Widely split S2

44
Q

what are the clinical features of pulmonary stenosis?

A

Dyspnoea, Fatigue, Oedema, Ascites
Dysmorphic facies
Prominent a wave in JVP
RV heave

45
Q

what investigations can be used for pulmonary stenosis?

A

ECG, echo, CXR, cardiac catherization

46
Q

which investigation is diagnostic of pulmonary stenosis?

A

Cardiac catherization

47
Q

What can the ECG features of pulmonary stenosis show?

A

RAD, p-pulmonale, RVH, RBBB

48
Q

what are the features of CXR of pulmonary stenosis?

A

prominent main, right or left pulmonary arteries cause by post stenotic dilation

49
Q

what is the management of pulmonary stenosis?

A

Pulmonary valvuloplasty or valvotomy

50
Q

what murmur is heard in pulmonary regurgitation?

A

descencdo murmur is heard in early diastole at the left sternal edge

51
Q

what is the cause of pulmonary regurgitation?

A

pulmonary hypertension