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Advanced Drug Delivery > Vaginal Delivery > Flashcards

Vaginal Delivery Flashcards

1
Q

What is the surface area of the vagina mucosa?

A

90 cm²

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2
Q

How can the cells of the vaginal mucosa be described?

A

Stratified squamous and non-keratinised

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3
Q

Is the vagina mucosa epithelium vascularised?

A

No

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4
Q

What are characteristics of the lamina propria?

A

Loose
Highly vascularised

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5
Q

What hormone reduces vaginal mucosa thickness?

A

Progesterone

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6
Q

What is the sequence of the vagina blood supply?

A

Common iliac artery> internal iliac artery> vagina arteries

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7
Q

What is the sequence of vaginal blood drainage?

A

Vaginal Venus plexus> vaginal veins> internal iliac veins
(Bypasses liver and FPM)

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8
Q

How is drug transported in the vagina?

A

Drug is administered to vagina
Drug enters veins
Drug enters the arteries ( uterine )
Arteries deposit drug and uterus

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9
Q

What is vaginal fluid made from and how much is produced daily?

A

Vagina mucus
Cervical mucus
Menstruation fluid
Endometrial fluid
6 g

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10
Q

What is a healthy vagina pH and how is this maintained?

A

3.5 to 5
Lactobacillus

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11
Q

When does the vagina pH rise?

A

During menstruation
Sex
Infection

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12
Q

What are advantages of vagina delivery?

A

Accessible
Non-invasive
Nonparental
Highly perfused
Avoids first past metabolism
Local or systemic effect

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13
Q

What are disadvantages of vagina delivery?

A

Cultural
Hygiene
Messy for semisolids
Poor compliance
Tissue permeability is influenced by oestrogen and fluctuations affect pharmacokinetics for systemic drugs

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14
Q

When would vaginal delivery be used?

A

For women’s healthcare
Spermicidal contraception
Labour induction
Oestrogen replacement
Vagina infections
Treat cervical vaginal cancer

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15
Q

What are characteristics of vaginal rings?

A

Passive diffusion controlled
One or more drugs controlled overtime
Patient inserts and removes
Local or systemic

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16
Q

What two types of vagina rings are there?

A

Matrix type- drug dispersed through entire ring volume
Reservoir type- drug dispersed through central core. More complex.

17
Q

What is an example of a vaginal ring?

A

NuvaRing- combined contraceptive inserted for 21 days continuous

18
Q

What are vaginal gels?

A

Water-based semi solids
Made of water and a gelling agent (carbomer)
Preservative and active drug
Plastic applicator

19
Q

What is an example of a vaginal gel?

A

Metrogel- metronidazole for bacterial vaginosis

20
Q

What are vagina polymer films?

A

Thin water soluble and polymeric
Dissolve rapidly in vaginal cavity with minimal fluid
Rapid drug release- spermicide

21
Q

What is a vaginal pessary?

A

It melts at the body temperature in vaginal cavity

22
Q

What are examples of vaginal pessaries?

A

Canestan for thrush
Cervidil- to induce labour at 42 weeks

Advanced Drug Delivery (15 decks)

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