VAGINAL CANCER

Question 1

NAME THE MOST IMPORTANT VAGINAL CANCERS

Answer 1

VAGINAL CARCINOMA
CLEAR CELL CARCINOMA
VAGINAL ADENOSIS
SARCOMA BOTRYOIDES

Question 2

WHAT IS THE MOST COMMON TYPE OF VAGINAL CARCINOMA?

Answer 2

USUALLY SQUAMOUS CELL CARCINOMA

Question 3

RISK FACTOR OF VAGINAL CARCINOMA

Answer 3

ALMOST ALWAYS INVOLVES HPV
SAME RISK FACTORS AS CERVICAL CANCER

Question 4

EXPLAIN THE LYMPHATIC DRAINAGE OF VAGINA

Answer 4

UPPER VAGINA – FROM MULLERIAN DUCT - ILLIAC NODES
LOWER VAGINA – FROM UROGENITAL SINUS-INGUINAL NODES

Question 5

EXPLAIN WHAT CLEAR CELL CARCINOMA OF THE VAGINA IS

Answer 5

Clear cell carcinoma of the vagina is a rare type of vaginal cancer, typically associated with prenatal exposure to the drug diethylstilbestrol (DES)

DIETHYLSTILLBESTROL, USED TO PREVENT MISCARRIAGE, PREMATURE BIRTH, REMOVED FROM US MARKET 1971.

FEMALE BABIES // REPRODUCTIVE TRACT ABNORMALITIES

Question 6

DIETHYLSTILBESTROL

Answer 6

ABNORMAL UTERUS, CERVIX
VAGINAL ADENOSIS
VAGINAL CLEAR CELL ADENOCARCINOMA
HIGH RATE INFERTILITY

Question 7

WHAT IS THE VAGINAL ADENOSIS

Answer 7

BENIGN CONDITION WHERE GLANDULAR TISSUE OR IT IS SECRETIONS ARE PRESENT IN THE VAGINAL WALL.
IT CAN OCCUR WHEN THE SQUAMOUS EPITHELIUM DOES NOT REPLACE THE COLUMNAR EPITHELIUM DURING EMBRYOGENESIS.

Question 8

SARCOMA BOTRYOIDES

Answer 8

RARE VAGINAL TUMOR OF YOUNG CHILDREN
MAY ALSO DEVELOP IN BOYS-PARATESTICULAR TUMORS OR ESCROTAL OR INGUINAL ENLARGEMENT
DERIVES FROM EMBRYONAL RHABDOMYOBLASTS, IMMATURE MUSCLE CELLS.
<5YEARSOLD
GRAPE LIKE MASS GROWING FROM VAGINA
APPEARANCE OF BUNCH OF GRAPE
MAY INVADE PERITONEUM –> OBSTRUCT BLADDER

Question 9

WHAT IS THE TREATMENT FOR SARCOMA BOTRYOIDES?

Answer 9

SURGERY AND CHEMOTHERAPY

Question 10

DESMIN

Answer 10

MUSCLE FILAMENT
PART OF Z DISK IN SARCOMERES
MARKER OF RHABDOMYOSARCOMA (SARCOMA BOTRYOIDES)
99% OF RHABDOMYOSARCOMAS POSITIVE FOR DESMIN