Vaccines/Immunizations Flashcards
Steroids and live immunizations
Delay all live vaccines for ONE MONTH after steroid treatment if:
- >20 mg/day OR >2 mg/kg/day
AND
- >14 days
Live vaccines
- MMR
- “Sabin”/oral polio
- Varicella/VZV
- Adenovirus (for military only)
- Yellow Fever
- Inhaled influenza
- Rotavirus
Patient populations that should not receive live vaccines
- Pregnant teen
- Severe immunocompromise (including patients with HIV and CD4 < 200 cells/microL
- *If patient has HIV and is generally healthy (CD4 >200), DO NOT withhold vaccines!**
Are lives vaccines contraindicated in patients with family members who are immunocompromised or pregnant?
NO!!
MMR and PPD
- PPD can be placed on the same day that MMR is given
- HOWEVER, if MMR was given < 6 weeks ago, DO NOT place PPD!
Side effects of MMR
- Fever 7-10 days after vaccine given
- Rash 7-10 days after vaccine given
- Joint pain of hands and knees for up to 1 month after vaccine given
Rotavirus vaccine
- DO NOT give at < 6 weeks or > 15 weeks of age
- 2 dose regimen: 2 & 4 months
- 3 dose regimen: 2, 4 and 6 months (max for 3 dose series is 8 months)
- DO NOT give to patients in the hospital
- Can be administered to patients with an immunocompromised family member
- Shed in stool
Influenza vaccine
- FluMist (currently off market) can be given to children >2 years of age, healthy, NOT pregnant, NOT immunocompromised, NOT asthmatic
- Children 6 months - 8 years receiving influenza vaccine for the first time should receive 2 doses (1 month apart)
Hepatitis A Vaccine
- Everyone receives Hep A vaccine
- First dose at 1 year. Second dose given at least 6 months later.
- Typically 12 and 18/24 months
Hepatitis B vaccination for infants >2000 g at birth
- Maternal Hep B negative = vaccine @ birth, then 2 additional doses given at 1-2 months, 4 months and 6 months. If combination vaccines are used -> birth, 2, 4 and 6 months.
- Maternal Hep B unknown = give vaccine within 12 hours of birth and test Mom. If Mom later found to be Hep B +, give HBIG within 7 days.
- Maternal Hep B positive = give Hep B and HBIG at birth, then complete series.
Hepatitis B vaccination for infants < 2000 g at birth
- Maternal positive OR unknown = vaccine AND HBIG at birth. THEN give normal 3 dose series as recommended.
- Maternal Hep B negative = delay first dose until age 1 month OR hospital discharge and complete series as usual.
Human Papilloma Virus (HPV) Vaccine
- Recommended for males and females
- Can be given as early as 9 years of age
- If < 15 years of age when first vaccine is given, give 2 doses (at least 6 months apart) starting at 11-12 years.
- If > 15 years of age when first vaccine given, give 3 doses on a 0, 1-2 month and 6 month schedule.
- Dose #3 has to be given at least 6 months after dose #1
- If dosing schedule is not followed, may continue dosing without having to restart series
Meningococcal Vaccine
- Give to ALL children at 11 years of age + booster at 16 years of age. Otherwise, give second dose about 3 years after first dose.
- For unimmunized college students living in a dorm, give ONE SHOT and NO BOOSTER
- Minimum age is 2 months.
- Children < 1 1 years may receive vaccine if at high risk (asplenic, having complement deficiency, generally immunocompromised, traveling to an endemic area)
Meningogoccal Subtype B vaccine
- Low risk patients -> given between 16-23 years old)
- High risk -> >10 years old after an outbreak, spleen damage or removal, compliment immune deficiency, taking eculizumab, microbiologists routinely working with N. meningitides
- ## Booster required
Postexposure prophylaxis of meningitis
- Only 1 case of exposure required for prophylaxis (in contrast, TWO documented cases are required to give prophylaxis for H. flu).
- If CLOSE INTIMATE contact of patient diagnosed with meningitis, give rifampin or ceftriaxone within 24 HOURS of diagnosis
- *Close, intimated contacts = person living in same home/roommate, nursery school, close contact with secretions (i.e. boy/girlfriend), HCPs who cam in contact w/ secretions (provided mouth-to-mouth, performed intubation or managed ETT)
Immunizations and pregnancy
- Tdap and inactivated influenza vaccine recommended in pregnancy
- Live vaccines are contraindicated
- HPV is not recommended
Postexposure prophylaxis of H. influenzae B
- TWO documented cases are required
- Treat with rifampin
- If immunization status unknown, also give Hib vaccine.
- If patient is FIRST PATIENT to be diagnosed, make sure to immunize household members
Postexposure prophylaxis of Pertussis
- Give macrolide to all household contacts, all high-risk contacts (infants, pregnant women in 3rd trimester, those with pre-existing illness and those with contact with infants and pregnant women).
- If unimmunized, give vaccine
- If < 6 weeks, give azithromycin
- If > 6 weeks, give erythromycin