Vaccine Immunology Flashcards
1
Q
Inactivated vaccines require ___ to be effective.
A
Multiple doses
2
Q
What is the mechanism of a polysaccharide vaccine?
A
- Inactivated
- T-cell independent (since they can only recognize peptides)
- Stimulate B cells
- Not consistently immunogenic in children
- Repeated doses do NOT cause a booster response
3
Q
The immunogenicity of polysaccharide vaccines can be improved by…
A
Conjugation - adding a protein molecule, makes the response T cell-dependent, more effective in children and displays a booster response
4
Q
What are adjuvants?
A
Substance added to vaccine to enhance the immune response
