Aging & Immunity

Question 1

What changes are seen in an aging immune system?

Answer 1

• Decreased T cell responses (decreased #, IL-2 production, diversity)
• Decreased T cell/APC interactions
• Antibodies have lower affinity for pathogens
• Decreased Treg leading to increased autoimmunity

Question 2

What should signs should raise concern for acute infection in an older adult?

Answer 2

• Lack of fever response, or temp >37.2
• Changes to mentation and LOC