Vaccination Flashcards
Childhood Vaccination Schedule
2 Months - DTaP/IPV/HiB - Pneumococcal conjugate vaccine
3 Months - DTaP/IPV/HiB - Meningitis C
4 Months - DTaP/IPV/HiB - PCV - Mengitis C
12-13 Months - HiB/Men C - PCV - MMR
3 Years 4 Months - DTaP/IPV - MMR
13-18 Years - Td/IPV
Girls 12-13 Years - HPV
D - Diphtheria T - Tetanus aP - acellular Pertussis IPV - Inactivated Polio HiB - Haemophilus influenze type b
Vaccinations given to at risk groups?
Anthrax, Hep A/B, Men ACWY, Rabies, Varicella (if not immune)
Travel Vaccinations?
Cholera, Hep A/B, Jap Encheph, Tick-Bourne Encheph, Typhoid, Yellow Fever
Central Memory cells - where are they found?
Found in Lymph nodes and tonsils - roll along and extravasate in High Endothelial Venules (HEVs)
Central Memory Cells - what do they produce?
Produce IL-2 (to support other cells)
Central Memory Cells - in which population CD4/CD8 are they more prevalent in?
More central memory in CD4 population
Central Memory Cells - CCR7? CD62?
CCR7+ and CD62L+
Allow entry via HEVs to lymph nodes
Effector Memory Cells - Where are they found?
Liver and Lungs and Gut
Effector Memory Cells - CCR7? CD62?
CCR7-ve and CD62 low (therefore not found in lymph nodes
Effector Memory Cells - What do they produce?
Perforin and IFN- gamma
Effector Memory Cells - in which population CD4/CD8 are they more prevalent in?
More effector memory in CD8 population
How does CCR7 have its effects?
binds CCL19 and CCL21 present on the luminal surface of endothelial cells in lymph nodes which causes firm arrest and the initiation of extravasation
how does CD62L have its effects?
Interacts with a molecules on HEV, which mediates attachment and rolling
B cell Memory - what are they? what are their effects/ what do they produce?
Memory cells that can differentiate into plasma cells
Quicker response, more antibodies, higher affinity antibodies, more IgG and generally better antibodies
T helper cell response - Th1?
Cell mediated, involved cytokines IL-2, IFN-gamma, TNF
