Hypersensitivity Disorders - Autoantibodies

Question 1

What autoantibody is associated with … Antiphospholipid Syndrome (Hugh’s syndrome) ?

Answer 1

IgG Antibodies against cardiolipin and beta2 glycoprotein, lupus anticoagulant

Question 2

What autoantibody is associated with …Autoimmune Hepatitis?

Answer 2

IgG - Anti-smooth muscle antibody, anti-liver kidney microsomal-1 (anti-LKM-1). Anti Soluble Liver antigen (anti-SLA)

Question 3

What autoantibody is associated with …Autoimmune haemolytic anaemia?

Answer 3

IgG- Anti-Rh blood group antigen

Question 4

What autoantibody is associated with … Autoimmune Thrombocytopenic Purpura?

Answer 4

IgG - Anti-Glycoprotein IIb-IIIa or Ib-IX antibody

Question 5

What autoantibody is associated with … Churg-Strauss Syndrome (eGPA)?

Answer 5

Perinuclear/protoplasmic-stainng antineutrophil cytoplasmic antibodies (p-ANCA)

Question 6

What autoantibody is associated with … Coeliac disease?

Answer 6

IgA - Anti-tissue transglutaminase antibody, Anti-endomysial antibody

Question 7

What autoantibody is associated with … Congenital heart block in infants of mothers with SLE?

Answer 7

IgG - Anti-Ro antibody

Question 8

What autoantibody is associated with … Dermatitis hepetiformis?

Answer 8

IgA - anti-endomysial antibody

Question 9

What autoantibody is associated with …Dermatomyositis?

Answer 9

IgG - Anti-Jo-1 (t-RNA Synthetase)

Question 10

What autoantibody is associated with … Diffuse Cutaneous Scleroderma?

Answer 10

IgG - Antibodies to Topoisomerase/Scl70, RNA Pol I, II, III, Fibrillarin (nucleolar pattern)

Question 11

What autoantibody is associated with … Goodpasture’s Syndrome?

Answer 11

IgG - Anti-GBM antibody

Question 12

What autoantibody is associated with …Graves Disease?

Answer 12

IgG - Anti-TSH Receptor antibody (stimuatory antibody)

Question 13

What autoantibody is associated with … Hashimoto’s Thyroiditis?

Answer 13

IgG - Antibodies to Thyroiglobulin and thyroperoxidase

Question 14

What autoantibody is associated with … Limited Cutaneous scleroderma (CREST)

Answer 14

IgG - Anti-centromere antibody

Question 15

What autoantibody is associated with … Microscopic Polyangitis (MPA)?

Answer 15

IgG- Perinuclear.protoplasmic-staining antineutrophil cytoplasmic antibodies (p-ANCA)

Question 16

What autoantibody is associated with … Mixed connective tissue disease?

Answer 16

IgG- Anti-U1RNP antibody (speckled pattern)

Question 17

What autoantibody is associated with … Myasthenia Gravis?

Answer 17

IgG- Anti-ACh Receptor Antibody

Question 18

What autoantibody is associated with … Pernicious anaemia?

Answer 18

IgG - Antibodies to gastric parietal cells (90%) and intrinsic factor (50%)

Question 19

What autoantibody is associated with … Polymyositis?

Answer 19

IgG - Anti-Jo-1 (t-RNA Synthetase)

Question 20

What autoantibody is associated with … Primary Biliary Cirrhosis?

Answer 20

IgG- Anti-mitochondrial antibody

Question 21

What autoantibody is associated with … Rheumatoid Arthritis?

Answer 21

IgG- Anti-CCP antibodies, Rheumatoid factor

Question 22

What autoantibody is associated with … Sjogren’s Sundrome?

Answer 22

IgG - Anti-Ro, Anti-La antibody (speckled pattern), 60-70% have positive RF

Question 23

What autoantibody is associated with … Systemic Lupus Erthematosis?

Answer 23

IgG - Antibodies to dsDNA+ histones (Homogenous) and Ro LA, Sm, U1RNP (speckled)

Question 24

What autoantibody is associated with … Type 1 Diabetes Mellitus?

Answer 24

IgG - Antibodies to Glutamate Decarboxylase and pancreatic beta cells

Question 25

What autoantibody is associated with … Wegener’s Granulomatosis (GPA)?

Answer 25

IgG - Cytoplasmic antinutrophil cytoplasmic antibodies (c-ANCA)