V - Blood-Brain Barrier Penetration Flashcards by Grazielle Verzosa | Brainscape

Q

Blood-Brain Barrier Penetration: Excellent with or without inflammation

A

Sulfonamides, Chloramphenicol, Trimethoprim, Metronidazole, Rifampicin, Isoniazid, Fluconazole, Flucytosine

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Q

Blood-Brain Barrier Penetration: Good only with inflammation

A

Cephalosporins (cefuroxime - 2nd gen., 3rd gen. parenteral except cefoperazone, 4th gen.), Imipinem + Cilastatin, Meropenem, Aztreonam, Ciprofloxacin, Vancomycin

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Q

Blood-Brain Barrier Penetration: Minimal or not good even with inflammation

A

Aminoglycosides, Tetracyclines, Lincosamides, Macrolides

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Q

Blood-Brain Barrier Penetration: No passage even with inflammation

A

Polymyxins, Cephalosporins (1st and 2nd gen. except cefuroxime), Amphotericin B

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Q

Blood-Brain Barrier Penetration: Sulfonamides

A

Excellent with or without inflammation

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Q

Blood-Brain Barrier Penetration: Chloramphenicol

A

Excellent with or without inflammation

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Q

Blood-Brain Barrier Penetration: Trimethoprim

A

Excellent with or without inflammation

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Q

Blood-Brain Barrier Penetration: Metronidazole

A

Excellent with or without inflammation

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Q

Blood-Brain Barrier Penetration: Rifampicin

A

Excellent with or without inflammation

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Q

Blood-Brain Barrier Penetration: Isoniazid

A

Excellent with or without inflammation

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Q

Blood-Brain Barrier Penetration: Fluconazole

A

Excellent with or without inflammation

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Q

Blood-Brain Barrier Penetration: Flucytosine

A

Excellent with or without inflammation

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Q

Blood-Brain Barrier Penetration: Cephalosporins (cefuroxime - 2nd gen., 3rd gen. parenteral except cefoperazone, 4th gen.)

A

Good only with inflammation

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Q

Blood-Brain Barrier Penetration: Imipinem + Cilastatin

A

Good only with inflammation

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Q

Blood-Brain Barrier Penetration: Meropenem

A

Good only with inflammation

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Q

Blood-Brain Barrier Penetration: Aztreonam

A

Good only with inflammation

Q

Blood-Brain Barrier Penetration: Ciprofloxacin

A

Good only with inflammation

Q

Blood-Brain Barrier Penetration: Vancomycin

A

Good only with inflammation

Q

Blood-Brain Barrier Penetration: Aminoglycosides

A

Minimal or not good even with inflammation

Q

Blood-Brain Barrier Penetration: Tetracyclines

A

Minimal or not good even with inflammation

Q

Blood-Brain Barrier Penetration: Lincosamides

A

Minimal or not good even with inflammation

Q

Blood-Brain Barrier Penetration: Macrolides

A

Minimal or not good even with inflammation

Q

Blood-Brain Barrier Penetration: Polymyxins

A

No passage even with inflammation

Q

Blood-Brain Barrier Penetration: Cephalosporins (1st and 2nd gen. except cefuroxime)

A

No passage even with inflammation

Q

Blood-Brain Barrier Penetration: Amphotericin B

A

No passage even with inflammation