UWorld Week 1 Flashcards

1
Q

what vitals can be abnormal in delirium tremens?

A

fever, tachycardia, hypertension, diaphoresis

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2
Q

what are two options for treatment of binge eating disorder?

A

lisdexamphetamine and SSRI

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3
Q

what is delayed sleep wake phase disorder?

A

sleep onset insomnia and morning sleepiness

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4
Q

what is advanced sleep wake phase disorder?

A

early sleep and morning insomnia with tiredness

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5
Q

what is the test for CJD?

A

real time quaking induced conversion test

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6
Q

what are the symptoms of CJD?

A

dementia, myoclonus, ataxia, UMN signs, mood and sleep disorders

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7
Q

doxepin is what class of drug?

A

TCA

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8
Q

what is a common GI symptom of anorexia?

A

constipation

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9
Q

what is first line option for adult ADHD, meds or CBT?

A

meds first even with addictive history

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10
Q

what med can you give to adult with ADHD with addiction history?

A

atomoxetine

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11
Q

what is MoA of atomoxetine?

A

NE uptake inhibitor

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12
Q

periodic sharp wave complexes on EEG is suggestive of what

A

CJD

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13
Q

how does depression often present in young kids?

A

with somatic symptoms like stomach aches and headaches

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14
Q

do imaginary friends help or hurt real relationships

A

help

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15
Q

what ages are appropriate for imaginary friends?

A

3-6 but any age in childhood is OK

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16
Q

what is hyperventilation syndrome?

A

hyperventilation without a cardiac or pulmonary etiology

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17
Q

what are signs of hyperventilation syndrome?

A

increased respiratory rate and tidal volume

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18
Q

what is treatment for hyperventilation syndrome?

A

reassurance and breathing teaching

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19
Q

what are the three key features of Rett syndrome?

A

loss of hand movements, gait abnormalities and loss of speech

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20
Q

who gets rett syndrome?

A

mainly girls 6-18 mos

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21
Q

what is another feature of Rett syndrome aside from hand movement loss, loss of speech and gait abnormality?

A

seizures

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22
Q

what is testing for Rett syndrome?

A

DNA analysis

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23
Q

what is treatment for body dysmorphic disorder?

A

SSRI and CBT

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24
Q

describe nightmare disorder

A

patient awakes and remembers dream and then can be consoled

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25
Q

describe night terror disorder

A

patient awakes and does not remember dream and cannot be consoled

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26
Q

when do nightmares occur? when do night terrors occur?

A

nightmares are in REM and terrors not in RME

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27
Q

what is initial management of serotonin syndrome?

A

supportive care and sedation with benzos

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28
Q

if sedation and support does not work with serotonin syndrome, what can you give?

A

cyproheptadine

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29
Q

what does persistent complex bereavement syndrome center around? how does this differ from MDD?

A

yearning for the lost…in MDD you dont yearn for the lost

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30
Q

what antipsychotics are worst about causing galactorrhea?

A

high potency first generation

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31
Q

when is a functional tremor present?

A

at rest and with movement

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32
Q

what makes a functional tremor stop?

A

any distractions

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33
Q

what age group has slight increased risk for suicidal thoughts on SSRI?

A

age less than 25 years of age…

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34
Q

if a patient with bipolar is stable on lithium and wants off, what can you offer them?

A

nothing…need to stay on lithium for life

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35
Q

when does a physiologic tremor occur? what can make it increase?

A

anytime..stress and caffeine

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36
Q

what four classes of drugs cause a physiologic tremor to increase?

A

beta agonists
TCAs
SSRI
roids

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37
Q

what are the main symptoms of heroin withdrawal?

A

nausea, diarrhea, vomiting, cramping muscle aches

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38
Q

what are the physical findings of heroin withdrawal?

A

piloerection, dilated pupils, yawning, hyperactive bowel sounds

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39
Q

what are the two sleep changes in depression?

A

decreased REM sleep latency and decreased slow wave sleep

40
Q

what is REM sleep latency?

A

time from onset of sleep to REM sleep

41
Q

what endocrine abnormality is associated with depression? why?

A

overactivity of HPA leads to increased levels of cortisol

42
Q

what are two common comorbid diagnoses with tourette syndrome?

A

ADHD and OCd

43
Q

is NMS or serotonin syndrome rapid onset?

A

serotonin syndrome is rapid and NMS is slow

44
Q

what does NMS have that serotonin syndrome doesnt?

A

lead pipe rigidity

45
Q

what does serotonin syndrome have that NMS does not?

A

hyperreflexia, clonus and nausea vomiting

46
Q

NMS is caused by what kind of drugs?

A

dopamine antagonist

47
Q

steroids can induce what psychiatric problem?

A

psychosis

48
Q

what nt is down in huntingtons?

A

GABA

49
Q

what areas of the brain are affected in Huntingotns?

A

caudate and putamen

50
Q

what is treatment for adjustment disorder?

A

psychotherapy

51
Q

what are the two mainstays of treatment of anorexia nervosa?

A

psychotherapy and nutritional rehabilitation

52
Q

what eating disorder can you give SSRI for?

A

bulimia nervosa

53
Q

what is a common side effect of venlafaxine?

A

increased blood pressure…dose dependent

54
Q

what SNRI has increased BP as risk?

A

venlafaxine

55
Q

what is diagnosis of panic disorder?

A

recurrent attacks with worry or concern about more attacks or behavior changes due to attacks

56
Q

how long must you have the worry and behavior change related to panic attacks to be diagnosed with panic disordeR?

A

1 month

57
Q

what med can you give for nightmares in PTSD?

A

prazosin

58
Q

how long must symptoms last to get diagnosis of cyclothymic disorder?

A

more than 2 years

59
Q

what are the two criteria for diagnosis of bipolar II?

A

one MDD and hypomania

60
Q

how long does manic symptoms have to last to be called hypomanic?

A

more than 4 days

61
Q

what number of MDD episodes is considered chronic? what does this mean for treatment?

A

3 or more…means treatment for life

62
Q

what number of MDD episodes is considered recurrent? what does this mean for treatment?

A

2 or more…means eligibile for maintenance therapy

63
Q

how long does maintenance therapy for MDD last?

A

1-3 years

64
Q

when does adjustment disorder have to onset?

A

within 3 months of the stressor

65
Q

what are the two main criteria for adjustment disorder?

A

it doesnt match another DSM V diagnosis and it has an impact on function of patients life

66
Q

what is the initial management of NMS?

A

supportive care and stop meds

67
Q

if initial management of NMS fails, what two meds can be tried?

A

bromocriptine and dantrolene

68
Q

how does dantrolene help NMS

A

it is a muscle relaxant so decreases temperature

69
Q

how does bromocriptine help NMS?

A

dopamine agonist so helps minimize the blockade

70
Q

what two meds are used in bipolar depression?

A

quetiapine and lurasidone

71
Q

what SSRI is used in elderly population?

A

sertraline

72
Q

what SSRI is contraindicated in elderly? why?

A

citalopram…because can elongate QT

73
Q

2 main side effects of mirtazapine

A

weight gain and sedation

74
Q

what are the treatment options for body dysmorphic disorder?

A

SSRI and CBT

75
Q

aside from medication management, what else can be beneficial at reducing hospitalizations in patients with schizophrenia?

A

family therapy

76
Q

three vital signs for admission with anorexia

A

bradycardia <40
hypothermic <35
hypotensive <80/60

77
Q

what is indication of bad TCA toxicity?

A

QRS greater than 100 ms

78
Q

if TCA overdose leads to QRS greater than 100 ms, what is started?

A

sodium bicarbonate therapy

79
Q

name three indications for ECT in depression

A

emergency situations, treatment resistant, psychotic features

80
Q

what are some emergency situations in depression that mean you should use ECT?

A

pregnancy, refusal to eat or drink, and imminent suicide risk

81
Q

what must you use to formally diagnose a specific learning disorder?

A

standardized testing

82
Q

what is paradoxical agitation? what med is it associated with?

A

when taking benzos patients actually become agitated and aggressive and confused…common in elderly

83
Q

how do children with language disorder often express themselves?

A

they get irritated when no t understood and can thrown tantrums

84
Q

what does sulfonyurea do to levels of insulin and c peptide?

A

increases both

85
Q

what med group that is often used can contribute to memory impairment in elderly?

A

antihistamines due to anticholinergic effect

86
Q

when should you worry about meds causing cognitive decline in a patient?

A

if there is an abrupt onset

87
Q

how long to wait between stopping an SSRI and starting an MAO inhibitor to avoid serotonin syndrome?

A

2 weeks

88
Q

what are the features of reactive attachment disorder

A

child doesnt respond to comfort, poor social resposiveness, limited positive affect, unexpained irritability and aggressiveness

89
Q

what is cause of reactive attachment disorder?

A

insufficient care

90
Q

whatis treatment for reactive attachment disorder?

A

protective nurturing environment and therapy PRN

91
Q

what is difference in reactive attachment disorder and disinhibited social engagement disordeR?

A

Disinhited is an overfamiliarity with strangers following neglect/lack of care

92
Q

name two medication options for tourette syndrome

A

second gen antipsychotics and clonidine

93
Q

what is thought to be the mechanism of tardive dyskinesia?

A

upregulation of dopamine receptors that become super sensitive

94
Q

what two meds in parkinsons disease can be associated with psychosis?

A

dopamine precursors (carbidopa) and dopamine agonists (pramipexole)

95
Q

what are signs of stimulant intoxication?

A

irritable restless behavior, insomnia

96
Q

what are physical exam findings of stimulant intoxication? why?

A

sympathetic overactivity causes hypertension, hyperthermia diaphoresis and tachycardia

97
Q

what is first line med for stimulant intoxication?

A

benzos