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internship > UWORLD tumor translocations > Flashcards

UWORLD tumor translocations Flashcards

1
Q

Burkitt lymphoma

A

t(8;14) –> c-myc activation

Round nuclei with basophilic cytoplasm containing prominent lipid vacuoles

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2
Q

CML

A

t(9;22)

Myelocytes

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3
Q

B-ALL

A

t(12;21)

anemia, thrombocytopenia, lymphoblasts

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4
Q

follicular lymphoma

A

t(14;18) –> bcl2 activation

malignant cells with notches or clefts (centrocytes)

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5
Q

APL

A

t(15;17)

Auer rods

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6
Q

Mantle cell lymphoma

A

t(11; 14) –> cyclin D1 activation

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7
Q

AML responsive to ATRA, M3 subtype

A

t(15;17)

look for DIC

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internship (14 decks)

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