UWORLD tumor translocations Flashcards
1
Q
Burkitt lymphoma
A
t(8;14) –> c-myc activation
Round nuclei with basophilic cytoplasm containing prominent lipid vacuoles
2
Q
CML
A
t(9;22)
Myelocytes
3
Q
B-ALL
A
t(12;21)
anemia, thrombocytopenia, lymphoblasts
4
Q
follicular lymphoma
A
t(14;18) –> bcl2 activation
malignant cells with notches or clefts (centrocytes)
5
Q
APL
A
t(15;17)
Auer rods
6
Q
Mantle cell lymphoma
A
t(11; 14) –> cyclin D1 activation
7
Q
AML responsive to ATRA, M3 subtype
A
t(15;17)
look for DIC