MEN syndromes/Cofactors

Question 1

MEN 1:

Answer 1

parathyroid, pancreas, pituitary (3p’s)

Question 2

MEN 2a:

Answer 2

medullary, pheo, parathyroid (1m, 2p’s)

Question 3

MEN 2b:

Answer 3

medullary, marfanoid habitus, pheo (2m’s, 1p)

Question 4

B1 (name?) is a coenzyme for

Answer 4

B1 = thiamine.
Coenzyme for alpha-ketoacid decarboxylase (which degrades branched chain alpha-amino acids like leucine, isoleucine and valine)
B1 also cofactor for transkelotase

Question 5

Folic acid is required for

Answer 5

synthesis of purines, thymine, and certain amino acids. Plays role in single-carbon transfer reactions (as THF)

Question 6

Pyroxidine (B6) functions as a cofactor in which reactions/

Answer 6

transamination, decarboxylation, condensation and deamination