UWorld Test Questions

Question 1

What renal pathology has foci sclerosis and hyalinosis in some, but not all, glomeruli?

Answer 1

Focal segmental glomerulosclerosis

Question 2

What renal pathology has mesangial proliferation on light microscopy with mesangial immune deposits of IgA on electron microscopy?

Answer 2

IgA nephropathy

Question 3

What renal pathology has normal glomeruli on light microscopy, and diffuse effacement of podocytes on electron microscopy?

Answer 3

Minimal change disease

Question 4

What renal pathology has glomerular crescents composed of proliferating parietal and inflammatory cells on light microscopy?

Answer 4

Rapidly progressive glomerulonephritis

Question 5

What renal pathology has significant parenchymal ischemia that manifests as diffuse cortical tanning, tubular atrophy, and small crowded glomeruli?

Answer 5

Renal Artery Stenosis

Question 6

What renal pathology has mesangial expansion, glomerular basement membrane thickening, and nodular glomerular sclerosis?

Answer 6

Diabetic nephropathy

Question 7

What bone pathology shows radiographic findings of normal trabecular bone, mixed radio dense and radiolucent area, and periosteal new bone formation with lifting of the periosteum?

Answer 7

Osteosarcoma

Question 8

What bone pathology shows radiographic findings with a crescent sign showing subchondral collapse at the femoral head?

Answer 8

Avascular necrosis

Question 9

What bone pathology shows radiographic findings of osteophytes and joint-space narrowing?

Answer 9

Osteoarthritis

Question 10

What bone pathology shows trabecular thinning and possible fractures and is increased risk in patients with corticosteroid exposure?

Answer 10

Osteoporosis

Question 11

What bone pathology shows lytic or mixed/sclerotic lesions with cortical and trabecular thickening?

Answer 11

Paget’s disease of the bone

Question 12

What hematologic disease has round nuclei with basophilic cytoplasm containing prominent lipid vacuoles?

Answer 12

Burkett’s lymphoma t(8;14)

Question 13

What hematologic disease shows leukocytosis with many immature myeloid cells (myelocytes)?

Answer 13

CML t(9;22)

Question 14

What hematologic disease shows anemia, thrombocytopenia, and lymphoblasts?

Answer 14

ALL t(12;21)

Question 15

What hematologic disease shows malignant cells with notches or clefts (centrocytes)?

Answer 15

Follicular lymphoma t(14;18)

Question 16

What hematologic disease shows azurophilic, needle-shaped cytoplasmic inclusions?

Answer 16

APL (auer rods) t(15;17)

Question 17

What dermatologic condition consists of enlarged cells with intranuclear inclusions that fuse into ballooning multinucleate giant cells that ulcerate and form a crust?

Answer 17

Herpes simplex

Question 18

What dermatologic condition consists of have slow-growing papule with an ulcerated or rolled border with histopathology that shows nests or strands of basaxoid cells with hyper chromatic nuclei with peripheral palisading?

Answer 18

Basal cell carcinoma

Question 19

What dermatologic condition consists of non-umbilicate, skin-colored or pink papule and growths that show undulating epidermal hyperplasia with enlarged nuclei and cytoplasmic vacuolization (koilocytosis) that form perinuclear halos?

Answer 19

Verruca vulgaris

Question 20

What dermatologic condition consists of epidermal hyperplasia along with molluscum bodies with large cytoplasmic inclusions with papules that are pruritic with umbilicate centers of white, curd-like material?

Answer 20

Molluscum contagiosum

Question 21

What chemotherapy agent is known for causing ototoxicity?

Answer 21

Cisplatin

Question 22

What GI pathology shows cobblestone mucosa and transmural inflammation?

Answer 22

Crohn’s Disease

Question 23

What GI pathology shows crypt accesses and multiple pseudopolyps?

Answer 23

Ulcerative colitis

Question 24

What GI pathology shows neoplastic cells infiltrating beyond the lamina propria?

Answer 24

Colonic adenocarcinoma

Question 25

What GI pathology do macrophages with PAS-positive granules suggest with accompanying blood in the stool?

Answer 25

Whipple’s disease

Question 26

What GI pathology is strongly associated with cardiovascular disease and shoes mucosal hemorrhage, ecchymoses, and patchy necrosis?

Answer 26

Ischemic colitis