UWorld pearls Flashcards
HIT pathophys?
heparin causes conformational change on platelet surface protein (platelet factor 4) –> neoantigen exposed –> HIT antibodies form –> platelets aggregate
HIT diagnostic test?
immunoassay or functional assay (5-HT release assay)
What anticoag can cause protein C deficiency?
warfarin
What does protein C deficiency look like?
skin necrosis
Polycythemia vera tx?
phlebotomy
Uric acid stone prevention?
lots of fluids and potassium citrate
Name the 2 radiolucent stones.
uric acid, xanthine
Why potassium citrate in uric acid stones?
to alkalinize the urine, which makes the stones soluble
Best non-pharm BP tx?
DASH diet
Hairy cell leukemia diagnostic test?
bone marrow biopsy, flow cytometry
OD: hypoTN, bradycardia, diffuse bilateral wheezing, 1st degree AV block. Dx?
beta-blocker OD
Tx beta-blocker OD?
airway, fluids, IV atropine, IV glucagon
Dx? myopathy with anxiety, tachycardia, weight loss, fatigue
thyrotoxic myopathy (hyperthyroidism)
Pleural fluid protein / serum protein ratio in exudate?
> 0.5
Pleural fluid LDH / serum LDH in exudate?
> 0.6
Normal pleural fluid pH?
7.6
Normal transudate pH?
7.4-7.55
Normal exudate pH?
7.3-7.45
Tx candida esophagitis?
fluconazole
Aortic dissection sudden-onset SOB cause?
aortic valve regurg
Why is hypokalemia hard to correct in alcoholics?
hypomagnesemia
S/s acute digoxin tox?
GI symptoms, weakness, confusion
Pathogen of pityriasis?
Malassezia globosa
Tick bite, high fever, flu-like sxs?
Babesiosis
How to diagnose Babesiosis?
blood smear- Maltese cross
HIT sequelae?
thrombocytopenia
arterial and venous thrombi
S/s fibromuscular dysplasia?
female, tinnitus, HTN, HA, bruits
Tx actinomyces?
penicillin
PAS-positive macs?
Whipple’s disease
diarrhea, migratory arthritis, lymphadenopathy, low grade fever dx?
Whipple’s disease
Vesicles on cornea with dendritic ulcers?
herpes simplex keratitis
Tx Torsades in stable pt?
Magnesium
Med tx for SVT?
adenosine
Dx? recurrent sinusitis and otitis, auditory canal ulceration, fatigue, anemia, microscopic hematuria?
granulomatosis with polyangiitis
hypercalcemia + hypophos + high PTH + high urine Ca++?
primary hyperparathyroidism
hypercalcemia + hypophos + high PTH + low urine Ca++?
familial hypocalciuric hypocalcemia