UWorld Flashcards

1
Q

What is the frequency of a pill rolling tremor?

A

4-6 Hz

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2
Q

What patients have a festinating gait?

A

Parkinson’s

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3
Q

What are Lisch nodules? What disease are they seen in?

A

Tan, raised hamartomas of the iris; seen in NF1

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4
Q

What inherited neurocutaneous disorder are renal angiomyolipomas associated with?

A

Tuberous sclerosis

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5
Q

Deficiency of galactose-1-phosphate uridyl transferase causes what symptoms?

A

Infant with FTT, bilateral cataracts, jaundice, hypoglycemia; can see hepatomegaly and convulsions

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6
Q

How does galactokinase deficiency present?

A

Cataracts only

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7
Q

What dementia subtype presents with visual hallucinations and spontaneous parkinsonism?

A

Dementia with Lewy bodies

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8
Q

Patient presents with sudden loss of vision in right eye and h/o diabetes. Ophthalmoscopy reveals loss of fundus details, floating debris and dark red glow. What is the most likely diagnosis?

A

Vitreous hemorrhage - sudden vision loss and onset of floaters; fundus hard to visualize is key

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9
Q

What a frequently associated side effects of amitriptyline?

A

Orthostatic hypotension, lethargy (antihistamine effect), and anticholinergic effect (dry mouth, constipation, urinary retention)

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10
Q

How does Tick paralysis present?

A

Paresthesias and fatigue followed by ascending muscle paralysis.

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11
Q

How is Niemann-Pick disease differeant than Tay-Sachs disease?

A

NPD with HSM and areflexia; Tay-Sachs with hyperreflexia; NPD due to sphingomyelinase def.

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12
Q

What are the clinical features of Niemann-Pick Disease?

A

Loss of milestones, hepatosplenomegaly, cherry red spot macula, areflexia, feeding difficulties, hypotonia

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13
Q

What are the clinical features of Tay-Sachs disease?

A

Loss of milestones, feeding difficulties, hypotonia, cherry red macula, hyperreflexia

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14
Q

What enzyme is def. in Niemann-Pick disease?

A

Sphingomyelinase

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15
Q

What are the firstline treatments for cognitive symptoms of Alzheimer’s dementia?

A

Cholinesterase inhibitors: donepezil, galantamine, rivastigmine

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16
Q

What is amantadine? What is it used in?

A

Dopamine agonist; can be used in Parkinson’s

17
Q

What are the clinical features of hypothyroid myopathy?

A

Muscle pain, weakness in proximal muscles, delayed DTRs, myoedema, normal ESR, elevated CK