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UW3 (2020) > UW3 (10 HemeOnc) > Flashcards

UW3 (10 HemeOnc) Flashcards

1
Q

Prostate cancer

1) Common metastasis location?
2) Diagnostic? 2

A

1) Metastasis to Bones

2) X-ray, PET / Bone scan

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2
Q

ITP

1) Cause?
2) Labs? 5
3) Mild symptoms? Management?
4) Mod/Sev symptoms? Management? 4

A

1) ADAMS13↓
2) LDH ↑ / Hb ↓ / Haptoglobin ↓ / Schistocyte / Plt ↓ < 100
3) Asymptomatic / Petechia, Purpura = observation
4) Gingival bleed / epistaxis / Hemorrhage = Steroid, IVIG, Anti-D, Plasma Exchange

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3
Q

Doxorubicin

1) Common toxicity?
2) Baseline test before treatment? 2

A

1) Cardiotoxic

2) Baseline Echo / MUGA

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4
Q

NeoNatal PolyCythemia

  • Presentation / Complication?
  • Lab? 3
  • Management? 4
A
  • Hyperviscosity
  • Lethargy / Hypotonia
  • Hct > 65% , Gluc ↓, Bili ↑

1) Recheck @ venous sample
2) Asymptomatic = Observation (resolve < 24h)
3) IVF + Glucose
4) Exchange transfusion

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5
Q

IVC filter

  • Indications? 3
  • Complication
  • Does it provide mortality benefit?
A
  • AntiCoag complication
  • AngiCoag contraindication
  • AntiCoag failure @ DVT/PE
  • Recurrent DVT
  • No mortality benefit
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6
Q

Polycythemia

  • Definition? 2
  • Diagnostic? 3
A
  • Hb > 16.5 @ M
  • Hb > 18.5 @ F
  • Erythropoietin ↑ = chronic hypoxia / RCC
  • Erythropoietin ↓ = PC vera / MyeloProliferative
  • Carboxy Hb
  • Nocturnal pulse Ox
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7
Q

Metoclopromide

1) Mechanism?
2) Complication?

A

1) D2 blocker @ central & periphery

2) ExtraPhyamidal

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8
Q

Radiation CardioToxicity

  • Pathology / Mech?
  • Effects & presentation? 5
A

• Diffuse fibrosis @ myocardium interstitium

  • MI
  • Restrictive cardiomyopathy + Diastolic dysfunction
  • Constrictive pericarditis
  • Mitral/Aortic stenosis/regurgitation
  • Conduction defect (sick sinus / AV block)
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9
Q

CCL

Poor prognosis indication? 4

A
  • Multiple lymphadenopathy
  • HepatoSplenoMegaly
  • Anemia
  • Thrombocytopenia
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10
Q

HIT

  • Definition?
  • Management? 3
  • Follow up?
A

• Plt ↓ > 50%

  • Stop: heparin
  • Start: direct thrombin inhibitor (Argatroban, Bivdivudin, Fondaparinux)
  • Switch to warfarin after Plt > 150

• Avoid all heparin type for lifetime

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11
Q

Thalassemia minor / trait

Lab results? 4

A
  • MCV ↓
  • RDW n
  • RBC n
  • Ferritin n
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12
Q

Renal dysfuction coagulopathy

  • Labs? 4
  • Management? 5
A

• Bleed time ↑ / PT n / PTT n / Plt n

  • PRBC transfusion
  • Desmopressin (↑ F7 & vWF release)
  • Dialysis
  • Estrogen
  • Cryoprecipitate
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13
Q

SupraTherapeutic INR (management)

1) INR < 5
2) INR 5-9
3) INR > 9
4) Bleeding (active / severe)

A

1) Hold warfarin 1-2d / ↓ Warfarinn
2) Hold Warfarin / Monitor INR / Vit K PO (low dose)
3) Hold warfarin / Vit K PO (high dose)
4) Hold warfarin / Vit K 10mg IV / FFP & Factors

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14
Q

Patient with painless visual field disturbance, floater, eye pain, blurry vision. Diagnosed with Ocular Melanoma

1) Common location?
2) Diagnostic?
3) Management for small size?
4) Management for large size?
5) When is enucleation needed?

A

1) Pigmented nevous @ choroid
2) US / MRI
3) Small (< 10 mm dia, < 3mm thick) = Repeat exam q3-6m
4) Large (> 10mm dia, > 3mm thick) = Referral & Radiation
5) Enucleation @ Very large tumor, Extra scleral extension

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15
Q

OsteoMyelitis (treatment)

1) MSSA? 3
2) MrSA? 2
3) Sickle cell?
4) Sickle cell acute chest?

A

1) Nafcillin / Oxacillin / Cefazolin
2) Clindamycin / Vancomycin
3) MSSA/MRSA treatment + Ceftriaxone / Cefotaxime
4) Azithromycin + Ceftriaxone

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16
Q

Pancoast tumor

  • Horner syndrome presentation? 4
  • C8-T12 effects? 2
A
  • Ptosis
  • Meiosis
  • Enophthalmos
  • Anhidrosis
  • Weakness & Atrophy @ hands
  • Pain & Paresthesia @ hands / arm
17
Q

Warfarin OD

Reversal treatment?

A

• Prothrombin complex / FFP + Vit

18
Q

Iron deficiency @ children

Complications? 2

A
  • Psychomotor delay

* NeuroCognitive impairment

19
Q

SubTherapeutic INR (management)

A

• Admit + Heparin

20
Q

TTP

1) Labs? 4
2) Coag profile? 3
3) Treatment? 3

A

1) Hb ↓ / LDH ↑ / HaptoGlobin ↓ / Plt ↓
2) PT n / PTT n / Bleeding time ↑
3) Plasma exchange / Steroids / Rituximab

21
Q

What is Leukovorin?

When is it typically used?

A
  • Folinic acid (More potent than folic acid)

* Use with methotrexate

22
Q

Superior Vena Cava

  • Initial symptoms? 4
  • Cause?
  • Diagnostic?
A
  • Dyspnea
  • Persistent cough
  • Facial fullness
  • Neck pain
  • bronchogenic carcinoma
  • CT contrast @ neck & chest
23
Q

Sickle cell / Vaso occlusive pain

Treatment? 3

A

1) Pain control (NSAID + OP = Oxycodone / IP = Morphine)
2) Hydration
3) Transfusion

24
Q

Sickle cell / Acute chest

  • Symptoms? 4
  • X-ray finding?
  • Treatment? 3
A
  • Chest pain
  • Fever > 101.3
  • Wheeze / Cough / WOB ↑
  • Hypoxia

• New pulmonary infiltration

  • Ceftriazone + Azithromycin
  • IVF
  • Pain control

UW3 (2020) (19 decks)

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