UW cases: Bipolar Flashcards
(1) ] A 19-year-old woman is brought to the emergency department by the police after she was found trespassing at an animal shelter. The patient had keys to a rental van, as well as numerous collars and leashes. She says, “The shelter is going to sell the animals to labs, where they’ll do horrible experiments on them. I’m the only one who can save them!” The patient quit her retail job a week ago to spend more time researching escape routes for the animals. Throughout the evaluation, she interrupts the physician to yell at other patients and hospital staff walking by the room. She repeatedly refers to herself as a “cat burglar” and then laughs loudly for a few minutes. Physical examination is unremarkable and urine drug screening is negative. Which of the following additional features is most likely in this patient?
Decreased need for sleep
A key feature of mania is decreased need for sleep due to increased energy.
(2) 25 y/o woman + 3-week history of depressed mood, low energy, loss of motivation, and oversleeping following the break-up of a relationship. The patient is sleeping 12 hours each day and describes difficulty getting out of bed and showering and dressing in the morning. Her concentration is poor at work, and she has difficulty completing everyday tasks. The patient has no psychotic symptoms or suicidal ideation. She has a history of major depressive episodes at age 16 and 20. The patient was treated briefly with fluoxetine at age 20 but stopped the medication after a week as she did not like the way it made her feel. Following a rape at age 22, she was treated with trauma-focused psychotherapy for 6 months. The patient has no significant medical history. She drinks a beer several times a week and uses cannabis approximately once every other month. Physical examination is normal. After the physician discusses treatment options for depression, the patient chooses to have combination treatment with psychotherapy and medication. Which of the following would be most important to obtain prior to initiating pharmacologic treatment for this patient?
History of elevated mood
(2) prior to initiating antidepressants for a major depressive episode, all patients should be screened for????? why?
all patients should be screened for a history of hypomania/mania to rule out bipolar disorder.
All antidepressants can induce mania, with the greatest risk occurring in patients with bipolar disorder.
(2) Patients who have a major depressive episode and meet criteria for a past manic or hypomanic episode should be diagnosed with?
With bipolar disorder rather than unipolar major depressive disorder.
Antidepressant monotherapy should be avoided in these patients due to the risk of inducing hypomania/mania.
(2) This patient’s history of early-onset depression, poor tolerability to a previous trial of antidepressant treatment, and a depressive episode characterized by lethargy and hypersomnia are especially characteristic of bipolar depression and should warrant careful assessment.
nu bbz ar cia differential tarp MDD ir bipolar depression
(3) A 20-year-old woman is brought to the emergency department by police at 2:30 AM after she was caught attempting to scale a fence at the White House. The patient appears highly agitated and paces around the examination room. She has just flown in from out of state to “meet with the president about a foolproof plan for eliminating worldwide terrorism.” The patient has barely slept for the past week due to her intensive work on this plan. She speaks rapidly but periodically stops to shout, “I’m going to sue all of you for interfering with my right to meet with the president.” She refuses a cup of water offered by a nurse, flinging it across the room. The evaluation has to be stopped when the patient begins banging on the door and demanding to leave. Family history is significant for major depression in her mother. Temperature is 37 C (98.6 F), blood pressure is 148/84 mm Hg, pulse is 98/min, and respirations are 22/min. Urine drug screen is negative. Administration of which of the following medications is the most appropriate next step in management of this patient?
OLANZAPINE (vs valproate)
maniac episode
(3) First-line treatments for mania include? 3
antipsychotics (eg, olanzapine), lithium,
and anticonvulsant mood stabilizers (eg, valproate).
(3) Why in case was first line olanzapine?
Because this patient exhibits acute psychosis (eg, grandiose delusions) and escalating agitation (eg, shouting, banging on the door, throwing a cup of water), an antipsychotic such as olanzapine would be the next step in management because it can be administered intramuscularly and has a rapid onset of action. Both first- and second-generation antipsychotics are effective in managing mania and associated acute behavioral agitation.
Once this patient is calmer and willing to take oral medication, lithium or an anticonvulsant mood stabilizer could be given. Combination therapy with an antipsychotic plus lithium or valproate is often necessary to treat severe mania (eg, psychotic features, aggressive behavior, risk of harm to self or others).
(3) olanzapine - i/m
vaproate and lithium - per os
.
(3) acute mania table. Mx. Lithium - avoid in what?
in renal disease
(3) acute mania table. Mx. Valproate - avoid in what?
in liver disease
(3) acute mania table. Mx. antipsychotic - groups?
first and second generation
(3) acute mania table. Mx.
Combination in severe mania?
eg. antiphychotic plius lithium or valproate
(3) acute mania table. Mx. Adjunctive for insomnia, agitation?
benzodiazepines
(4) A 35-year-old woman comes to the office due to poor energy. She says, “Although I have no energy, I still can’t sleep and am up most of the night. I drag myself to work but barely get anything done because I have no motivation and can hardly concentrate. I’m a horrible wife and mother. I don’t want to go out anymore or do anything. All I want to do is hide in my room and get into bed.” The patient has a history of 3 prior episodes of depression beginning at age 18. She was also hospitalized 3 years ago for aggressive behavior following an arrest for unauthorized use of her company’s funds to finance a personal business venture. At that time, she had excessive energy, slept 2 hours a night, and believed that she had a brilliant idea that would revolutionize the computer industry. The patient has no history of recreational substance use. There is a family history of depression in her mother, whose condition responded well to tricyclic antidepressants. Mental status examination is remarkable for psychomotor retardation, frequent tearfulness, depressed mood, and suicidal ideation. Which of the following is the most appropriate pharmacotherapy?
Quetiapine
Dx? Bipolar I
(4) bipolar Tx scheme. MANIA. while episode, you give first line antipsychotic. what drug?
Haloperidol
(4) bipolar Tx scheme. MANIA. during episode you give Haloperidol —> change to?
Lithium
Valproic
2nd generation antipsychotic
(4) bipolar Tx scheme. MANIA. during episode you give any of: Lithium; Valproic; 2nd generation antipsychotic ——> whats next?
CONTINUE THESE DRUGS
(4) bipolar Tx scheme. DEPRESSION. 4 drugs?
Lithium
Olanzapine-fluoxetine
Lamotrigine
2nd generation antipsychotic
(4) bipolar Tx scheme. DEPRESSION. You give any of these: Lithium; Olanzapine-fluoxetine; Lamotrigine; 2nd generation antipsychotic. Whats next?
CONTINUE
(4) bipolar Tx scheme.
2nd generation antipsychotics drugs?
Quetiapine, olanzapine,
lurasidone (only depression).
(4) Bipolar disorder has different phases (acute mania, acute bipolar depression, maintenance).
.
(4) Antidepressant monotherapy is avoided in patients with bipolar I disorder due to the risk for inducing mania. Antidepressants can sometimes be used with antipsychotics (eg, olanzapine plus fluoxetine) or mood stabilizers to decrease the risk for an antidepressant-induced switch from depression to mania.
.
(4) Mood stabilizers (eg, lithium, lamotrigine).
Haloperidol is a first-generation antipsychotic that can be used in acute mania but not in acute bipolar depression