UW 2 Flashcards
switching from fluoxetine to MAIi
wait 5 weeks to prevent seretonin syndrome (fluoxetine has long HT)
seretonin syndrome - treatment
- stop all seretonergic medications
- supportive care, sedation with benzo
- refractory –> cyproheptadine)
switch to clozapine if extrapyramidal symptoms under antipsychotics
only if tardive dyskinesia
REM sleep behavior disorder
complex motor behaviours that occur during REM
- dream enactment can occur if the muscle atonia that usually accompanies REM sleep is absent or incomplete
- latter of the night (higher % of REM)
- very transient confusion after awake
- recall heir dreams but not movements
- older adult men
- may be prodromal for Parkinson or Lewy
depression refractory to 1 SSRI - next step
try a 2nd SSRI (then other drugs) change class if 2 dif medication of the same class do not work
Best predictor of complication after TCA overdose
QRS longer than 100 msec
best initial therapy for major depression
SSRI with CBT
gambling disorder diagnosis is based on 4 or more of the following
- gambling when distressed
- depressed or anxious
- increased gambling to achieve the desired excitement
- frequently returning to gambling to recover past losses
- preocppation with gambling
- irritability and distress when trying to cut back on gambling
- repeated unsuccessful attempts to cut back
- trying to conceal the extend behaviors
- damaging relationships or jeopardizing employment
- relying on others to make up for financial loses
start SSRI for Major depression - when to stop them
if single episode of major depression –> continue for additional 6 months following acute response to reduce the risk of relapse
with chronic, recurrent or severe episodes –> 1-3 years
cancer patient with depression - what to say
offer treatment (don't say it is normal: it will negatively affect the treatment)
post traumatic stress disorder - treatment
- trauma focused CBT
- SSRI or SNRI
- prazosin for nightmares
drug of choice in pediatric depression
fluoxetine
Pharmacotherapy of psycjosis
- antipsychotics 2nd generation
- adjunctive benzo for agitation
- chronic nonadherence: lonsider long actinve injectable
- Treatment resistance (2 failed trials): consier clozapine
oppositional defiant disorder - time
at least 6 months
patient with acute mania and psychosis - best initial treatment
antipsychotic
causes of FP amphetamine urine test
selegiline, bupropion, decongestant pseudoephedrine
kelptomania - characteristics
stolen objects have little value
- increasing tension prior to theft –> pleasure or relief after
- guilt or remorse are common
- stolen objects given away, discharged or returned
kleptomania vs shoplifting
shoplifting is much more common, theft for personal gain
- In kleptomania, ovewrwhelming fellings of tension r anxiety precede impulses and are releived with the act of theft (guilty and shame)
kleptomani treatment
CBT oreientation focusing on techniques to resist and manage urges and anxiety
medications: SSRI, opiod antagonists, lithium, anticonvulsants
new onset (childhood) schizo - characteristic
poor prognosis
schizophreniform vs schizophrenia beside duration
only schizophrenia requires functional decline
antipsychitics vs prolactinoma regarding levels of prolactin
prolactinoma: more than 200
medications: 25-100
medications that decreases lithium levels
theophylline
K+ sparing diuretics
treatment of bipolar in renal failure
valproate
Marchiafava-Bgnami disease
dementia, motor dysfunction, dyrsarthria
- severe damage to the corpus callosum and surrounding white matter in the contex of chronic alcohol use disorder and malnutrition
Korsakoff - kind of amnesia / another characteristics)
retrograde and anterograde with intact long memory
sometimes develops without Wernicke - normal neurological examination
catatonia?
syndrome seen in severe psychiatric and medical illness and is characterized by immobility, mutism, posturing
Lorazepam and electroconvulsive therapy are the treatments of choice
antipsychotics - long QT?
only ziprasidone in very high doses
some chronic methammphetamine users can develop
persistent psychosis: difficult to distinguish from primary psychiatric disorders –> visual and tactile hallucinations tend to be more common in substance-induced psychotic disorders –> long term management with CBT and antipsychotics
narcolepsy - treatment
- sleep hygiene and scheduled naps
- if leepiness impairs daily functioning na dposes safety risks –> modafinil (nonamemphetamine medication)
- if significant cateplexy –> antidepressants and sodium oxybat
immediate treatment of depression with SSRI –>
it is not depression –> its bipolar
borderline - treatment
1st line: dialectical
- adjunctive pharmacotherapy to target mood instability + transient psychosis (2nd feneration antipsychotics, mood stabilizers)
- antidepressants if comorbid mood or anxiety disorder
alcohol withdrawal - which benzo
lorazepam (intermediate HT and does not metabolized by liver)
adjustment disorder
emotional or behavioral symptoms that develop within 3 months of exposure to an identifiable stressor and rarely last more than 6 months (no criteria for major depression)
- treatment: psychotheray
nightmare disorder
recurrent episodes of awakening from sleep with recall of highly disturbing and frightening dream content
- full alert on awakening
- usually consoled
another SE of marijuana overdose
dry mouth
tachycardia
slow reaction time
transient global amnesia
anterograde amnesia fro time and place that resolve in 24 h