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Uveitis Flashcards

1
Q

Which 6 retinal vasculitis affect venules?

A
  1. Sarcoid
  2. MS
  3. Birdshot
  4. Eales
  5. Bechets
  6. HIV paraviral syndrome
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2
Q

Which 7 retinal vasculitis affect arterioles?

A
  1. SLE
  2. PAN
  3. Necrotizing herpetic retinitis (ARN)
  4. Syphilis
  5. VZV (PORN)
  6. IRVAN
  7. Churg-Strauss syndrome
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3
Q

Which 2 bugs are the cause of late bleb associated endophthalmitis?

A
  1. H flu

2. Strep

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4
Q

Granular CMV retinitis occurs where?

A

Peripherally

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5
Q

What are 3 types of polymorphonuclear leukocytes?

A
  1. Neutrophils - most abundant granulocytes in the blood
  2. Eosinophils - IL-5 most impt mediator
  3. Basophil / mast cell
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6
Q

What are the steps of the immune response arc?

A
  1. Afferent
  2. Processing
  3. Effector
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7
Q

What is type V hypersensitivity?

A

Stimulatory

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8
Q

CAR is seen in what 2 dx?

A
  1. Small cell lung CA

2. Cutaneous melanoma

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9
Q

What is the outer layer of zonal inflm?

A

Fibrotic reparative or granulation tissue infiltrated with NONgranulomatous inflm and plasma cells, presumably secreting specific Antibodies.

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10
Q

What causes an eosinophilic granuloma in the eye?

A

Toxocara granuloma (strong Th2 response)

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11
Q

Which anterior uveitis has moderate severity (red, painful) that has a poor response to steroids?

A

Syphilis

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12
Q

Is vitiritis present in serpiginous choroidopathy?

A

NO

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13
Q

Which 5 Posterior Uveitis with Arteritis and Phlebitis?

A
  1. Toxoplasmosis
  2. Relapsing polychondritis
  3. Wegener granulomatosis
  4. Crohn dx
  5. FROSTED BRANCH ANGITIS
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14
Q

Which cell is the predominant inflm cell in the eye in uveitis?

A

lymphocytes

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15
Q

When are 3 instances when corticosteriods are not indicated?

A
  1. Fuchs heterochromic iridocyclitis
  2. Pars planitis WITHOUT CME
    * 3. peripheral lesions in toxoplasmosis not affecting optic disc or macula**
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16
Q

Recurrent anterior nongraunulomatous uveitis is what?

A

HLA-B27 - DDx

  1. Ankylosing spondylitis
  2. Reiter syndrome (reactive arthritis)
  3. Inflm bowel dz
  4. Psoriatic arthritis
  5. postinfectious, or reactive, arthritis
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17
Q

Pulmonary apical fibrosis and aortitis that is a/w aortic valve insufficiency are complications of what?

A

Ankylosing spondylitis

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18
Q

What is the most common eye lesion in Reiter syndrome?

A

Conjunctivitis - mucopurlent and papillary

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19
Q

What 4 drugs cause uveitis?

A
  1. Rifabutin
  2. biphosphanates
  3. sulfonamides
  4. diethylcarbamazine (an antifilarial agent)
  5. oral contraceptives
20
Q

What is the tx for Fuch’s heterochromic iridocyclitis?

A

Topical steriods BUT not aggressive tx because inflm persists for decades with good prognosis.

21
Q

HLA-DR15?

A

Multiple sclerosis

22
Q

HLA-DR15 and HLA-DR51?

A

Pars planitis

23
Q

What are the 4 tx steps for Pars planitis?

A
  1. Periocular steriods
  2. Peripheral ablation - PRP / cryo
  3. PPV, EL
  4. Systemic immunomodulatory agents
24
Q

Hep B as a causitive factor with hypertensive retinopathy, cranial nerve palsy, Horners is caused by what?

A

Polyarteritis nodosa

25
Q

Which surgery is the main risk for developing SO?

26
Q

How do PIC and MFC differ on FA?

A

Early hyperflurorescence in PIC; both have late staining. (MFC has early blockage)

27
Q

What type of inflm is seen in Bechets?

A

NONgranulomatous

28
Q

Which 3 d/o do u see stellate KP - diffuse corneal distribution?

A
  1. Fuch’s heterochromic iridocyclitis
  2. CMV
  3. Toxoplasmosis
29
Q

What are the 3 presentation of CMV-R?

A
  1. Classic or fulminant retinitis, typically appearing in the PP
  2. Granular or indolent - found more in the periphery
  3. Perivascular - similar to frosted branch angitis
30
Q

Migratory arthritis in white males with CN palsys with less than 5% of cases having b/l panuvetis and vasculitis is what?

A

Whipple dx. Tx with Bactrim

31
Q

A hypopyon occuring in the subretinal or subhyloidal space with hemorrhage in all retinal layers occurs in what?

A

Aspergillus endophthalmitis

32
Q

What 3 d/o present with a pseudohypopyon?

A
  1. Bechets
  2. Leukemia
  3. Retinoblastoma
33
Q

CWS with a lesion size over 750um is suggestive of what?

A

Very early CMV retinitis

34
Q

Cidofovir 2SE are what?

A
  1. Hypotony

2. Anterior uveitis (immune reconstitution uveitis)

35
Q

HLA-B7/ HLA-DR2?

36
Q

Cyclosporine / Tacrolimus SE and mechanism?

A

Nephrotoxicity; T cell signaling

37
Q

Sjogren’s causes what type of uveitis?

A

Intermediate

38
Q

Ig not in tears?

39
Q

Which drug is the best at treating Bechets?

A

Chlorambucil

40
Q

When should a steroid sparing agent be used when what level of steriod has been exceeded for a day?

41
Q

What cause drug induced lupus?

A

Inflixamab

42
Q

Which uveitis has an initial increase in IOP?

A

HERPETIC!!

43
Q

Bechcets is HLA?

44
Q

Which dz has life threatening laryngeal inflm?

A

Relapsing polychondritis

45
Q

Keratoderma blennorrhagicum is what and seen in what?

A
  1. Skin lesions on the palms and soles of feet

2. REITER’s syndrome

Retina / Uveitis (2 decks)

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