Uveitis Flashcards

1
Q

uvea

A

vascular middle coat of the eye made of the

  • iris
  • choroid
  • ciliary body
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2
Q

what makes up the anterior uvea?

A

iris

ciliary body

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3
Q

What makes up the blood aqueous barrier?

A

Tight junctions b/w

  1. endothelial cells of iris vasculature
  2. nonpigmented epithelium of ciliary body
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4
Q

what is the term for inflammation of the iris?

A

iritis

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5
Q

Inflammation of iris and ciliary body

A

Iridocyclitis

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6
Q

inflammation of the whole uvea

A

Panuveitis

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7
Q

Inflammation of uveal tract and ocular cavities

A

Endophthalmitis

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8
Q

inflammation of all 3 tunics of the eye (nervous, vascular, fibrous)

A

Panophthalmitis

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9
Q

What are three effects of inflammation on the uveal tract?

A

vessels dilate
vessels leak
breakdown of BAB

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10
Q

What are important inflammatory mediator involved in uveitis? What is caused?

A

PG (especially PGF2alpha)

  • Hyperemia
  • Decreased IOP
  • Miosis
  • Pain (squinting, tearing, photophobic)

Leukotrienes: chemotactic

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11
Q

What is the hallmark of uveitis?

A

Aqueous flare

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12
Q

What is aqueous flare?

A

Increased protein in anterior chamber (proteins from vessel damage)

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13
Q

Term for pus in the eye

A

Hypopyon

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14
Q

Term for blood in the eye

A

Hyphema

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15
Q

What are keratic precipitates?

A

inflammatory cells stuck in the cornea

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16
Q

What are some chronic signs of inflammation?

A
  • cataracts
  • posterior synechia
  • deep corneal vascularization
  • iris bombe
  • lens luxation
  • secondary glaucoma
  • phthisis bulbi
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17
Q

what is posterior synechia?

A

iris adherent to anterior lens capsule

Looks like iris has been smeared on lens

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18
Q

what is the #1 cause of cataracts in horses and cats?

A

Uveitis

19
Q

What is rubeosis irididis?

A

A preiridal fibrovascular membrane formation due to chronic inflammation

20
Q

Describe deep corneal vascluarization

A

small, straight, deep vessels coming from the limbus

21
Q

What is iris bombe?

A

360 degree posterior synechia
traps aqueous humor
iris bows forward

22
Q

What makes the aqueous humor?

A

ciliary body

23
Q

What can cause secondary glaucoma with uveitis?

A
  • iris bombe
  • lens luxation
  • scarring of ICA
24
Q

How does uveitis cause lens luxation?

A

Inflammatory mediators and byproducts breakdown the zonular fibers

25
Q

What is the last thing to happen with chronic uveitis?

A

Phthisis bulbi

26
Q

What would cause you to worry about secondary glaucoma due to uveitis?

A

Aqueous flare + miosis with elevated IOP

If IOP is within normal limit – in danger of secondary glaucoma

27
Q

Why is there a decrease IOP with uveitis?

A

Draining angle is working properly

Ciliary body isn’t producing aqueous humor like it should

28
Q

What two topical steroids are used for anterior uveitis? Why are these used?

A
  1. Neomycin + Polymyxin B + Dexamethasone
  2. Prednisolone Acetate

both penetrate the eye

29
Q

What is the term for paralysis of the ciliary body?

A

Cycloplegia

30
Q

What are two topicals that dilate the pupil? Hint: one is used for eye exams, the other is used for therapy

A

Tropicamide

Atropine

31
Q

Causes of uveitis

A
  • idiopathic
  • lens induced
  • neoplasia
  • infectious causes
32
Q

What are the big 4 infectious causes of uveitis in cats?

A
  1. FeLV
  2. FIV
  3. FIP
  4. Toxoplasmosis
33
Q

Name two lens induced causes of uveitis

A
  1. Phacolytic - leaking of lens proteins through capsule

2. Phacoclastic - drastic: lens capsule ruptured and large amounts of lens protein exposed

34
Q

What are some neoplasia that can cause uveitis?

A
  1. Uveal melanoma
  2. Ciliary body adenoma
  3. Metastatic (often lymphoma)
35
Q

The uvea is responsible for what 3 things?

A
  1. regulating and controlling scatter of light
  2. providing nourishment to interior of eye
  3. removing waste products
36
Q

What are the two muscles of the iris?

A
Iris dilator (longitudinal muscle)
Iris constrictor (circular muscle located in pupillary zone)
37
Q

What are the two layers of the ciliary body?

A

Nonpigmented outer layer - produces aqueous humor

Pigmented inner layer - continuous with pigmented outer layer of iris

38
Q

Trace the flow of aqueous humor

A

produced by ciliary body –> posterior chamber –> pupil –> anterior chamber –> exits through iridocorneal angle

39
Q

What two parts make up the ciliary body?

A
  1. pars plicata (produces aqueous humor) - base of iris

2. pars plana - extends from pars plicata to retina

40
Q

What attaches to the ciliary body?

A

zonular fibers of the lens

41
Q

What is the general treatment for uveitis?

A
  1. Topical Steroids (neopolydex, or prednisolone acetate)
  2. Topical NSAID (flurbiprofen)
  3. Systemic NSAID
  4. +/- systemic corticosteroids
  5. Topical atropine
42
Q

How are we controlling inflammation in uveitis?

A

Topical steroid and NSAID only works for anterior uveitis because it is topical

systemic medications will help get the posterior segment

43
Q

Why are we giving atropine for treatment of uveitis?

A

relieves ciliary spasm that causes significant amount of discomfort
minimizes chance of posterior synechia