Uveal Tract Flashcards

page 140-158

1
Q

Where does the choroid lie?

A

Between sclera and RPE. Extends from optic nerve to ciliary body.

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2
Q

Where is the chord thickest and where is it thinnest (include measurements)?

A

Thickest at posterior pole (022.mm)
Thins gradually anteriorly to 0.1mm

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3
Q

Describe inner vs outer surfaces of choroid?

A

Inner surface = smooth (firmly attached to RPE), outer surface = rough

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4
Q

Where is choroid adherent to sclera?

A

Site of exit of vortex veins and optic nerve head

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5
Q

What happens to choroid at optic nerve head?

A

Becomes continuous with Pia and arachnoid

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6
Q

Name the space found between sclera and choroid

A

perichoroidal space

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7
Q

What runs across and within perichoroidal space?

A

Across = thin, pigmented connective tissue - suprachoroid lamina

Within = long and short posterior ciliary arteries and nerves

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8
Q

Name the two layers of the choroid

A

1) vascular layer
2) Bruch’s membrane

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9
Q

VASCULAR LAYER CHOROID

Name three layers from inner to outer

A

Choriocapillaris (capillary layer)
Sattler’s layer (medium vessel layer)
Haller’s layer (Large vessel layer)

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10
Q

CAPILLARY LAYER CHOROID

What size and type of vessel?

What are these vessels supported by?

A
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11
Q

Sattler and Haller’s layers choroid:

a) What type of tissue found here
b) What kind of cells beside those forming blood vessel
c) size of blood vessels
d) where do they branch from and extend to
e) how do they compare to arteries found elsewhere in body
f) size of veins compared to arteries, what do they join to form?

A

VESSEL LAYER CHOROID

a) loose connective tisse
b) Melanocytes
c) large-medium sized blood vessels
d) Branches of short posterior ciliary arteries - extend anteriorly
e) both contain internal elastic lamina + smooth muscle media
f) veins = larger, join to form 4-5 vortex veins that pierce sclera to join ophthalmic veins

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12
Q

CHORIOCAPILLARIS

a) inner or outer layer?
b) diameter of capillaries
c) Features of vessel walls
d) supporting cell name and role
e) where is density highest and lumen widest?
f) What is supply and where do they drain to?

A

a) inner
b) 40-60microns
c) thin wall, fenestrated
d) pericytes
e) macula
f) arteries from vessel layer (Sattler’s and Haller’s), drain to veins in vessel layer

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13
Q

BRUCH’s MEMBRANE

a) how many layers
b) name the layers

A

a) five
b)
1) BM of endothelium of capillaries in choriocapillaris
2) outer layer of collagen
3) meshwork elastic fibres
4) inner layer collagen fibres
5) BM RPE

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14
Q

BRUCH’s MEMBRANE CONT

a) how thick is Bruch’s membrane?
b) what is it’s function?

A

a) 2-4microns
b) unknown ?fluid transport from choroid to retina

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15
Q

Nerve supply of choroid
- what other fibres do they carry?

A

long and short ciliary nerves
- long carry sensory and sympathetic
- short carry sympathetic and parasympathetic

pierce sclera around optic nerve, travel anteriorly through supra choroidal space

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16
Q

What are the long ciliary nerves branches of?

A

nasociliary nerve, branch of ophthalmic division of trigeminal nerve

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17
Q

Where do the short ciliary nerves arise from?

A

ciliary ganglion

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18
Q

What is the function of the choroid?

A
  • nourish outer layers of retina
  • conduct blood vessels forward to anterior portion of eye
  • heat exchange from retina
  • may assist in regulating IOP
  • absorb light penetrating retina, preventing reflection
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19
Q

CILIARY BODY

what are the functions of the ciliary body?

A
  • aqueous formation
  • lens accommodation
  • aqueous drainage via uveoscleral outflow and trabecular system
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20
Q

CILIARY BODY

gross structure of ciliary body
- shape + cross section
- width
- continuous with what structure anteriorly and posteriorly
- extends forwards and backwards to which structures

A

Doughnut-shaped, triangular in cross section (base faces AC, anterior outer angle faces scleral spur. Apex extends posteriorly and laterally to become continuous with choroid. Anterior surface = ridged and is called pars plicata)

6-7mm wide (temporal > nasal)
Anteriorly continuous with peripheral margin iris
posteriorly continuous with choroid

extends forwards to scleral spur and backwards to ora serrata

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21
Q

CILIARY BODY - origin and insertion points

originates how far posterior to limbus
how far posterior to this does it extend on temporal vs nasal side

A

starts 1.5mm posterior to limbus

temporally: extends a further 7.5-8mm posteriorly to this point

nasally: a further 6.5-7mm posterior to this point

(ie wider temporally than nasally)

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22
Q

CILIARY BODY

which two parts can the ciliary body be split into

A

pars plana and pars plicata

Plana - anterior surface
plicata - posterior surface

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23
Q

CILIARY BODY

In which part of the ciliary body are the ciliary processes found?

A

Pars plicata

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24
Q

CILIARY BODY

Where do the lens zones attach?

A

Attach to the pars plicata at intervals between the ciliary processes

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25
Q

CILIARY BODY

Where is the equator of the lens in relation to the ciliary processes?

A

0.5mm away

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26
Q

CILIARY BODY

Describe the appearance of the posterior margin of the pars plana, which structure is adjacent to this?

A

scalloped edge, fits into and corresponds with ora serrate of neural retina

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27
Q

The layer of choroid comprising large arteries and veins is which of the following:
Bruch’s membrane
Haller’s layer
Sattler’s layer
the choriocapillaris

A

Haller’s layer lies within the choroid and comprises large arteries and veins. Sattler’s layer, which lies above Haller’s layer, is composed of arterioles and venules which supply the choriocapillaris directly above.

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28
Q

Why is the pars plana surgically an important anatomic structure?

A

The pars plana is surgically an important anatomic structure. Because of its relative avascularity and position anterior to the retina, incisions through the sclera and choroid into the vitreous should be made at this point to avoid hemorrhagic complications and retinal detachments.

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29
Q

Why may a lesion in the choroid result in retinal atrophy?

A

Because the uveal tract provides nourishment for the outer part of the retina, a lesion of the choroid may interfere with nutrition to the adjacent retina and cause atrophy and destruction of the retina.

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30
Q

CILIARY BODY

Which three structures is the ciliary body made of? Which one forms the bulk of it?

A

Ciliary epithelium
Ciliary stroma
Ciliary muscles

Ciliary muscles

31
Q

CILIARY EPITHELIUM

a) How many layers
b) which type of cell
c) what does it correspond to embryologically
d) describe appearance of inner layer, what is it continuous with, do they line any other area of the eye?
e) Describe the appearance of the outer layer, what is it continuous with? What does it sit on?
f) describe orientation of cells of inner and outer epithelial layers relative to each other?
g) are these layers in contact with each other?

A

a) 2
b) cubical
c) two layers of optic cup
d) non-pigmented, continuous with nervous part of retina. Also lines AC
e) pigmented, continuous with RPE, sits on ciliary stroma (ie it is OUTER LAYER :p)
f) base of inner layer faces into eye, base of outer layer faces towards stroma of epithelium => cells sit apex-to-apex
g) at points separated by small ciliary channels

32
Q

CILIARY EPITHELIUM

a) What is the basement membrane of the non-pigmented layer continuous with?
b) what is the basement membrane of the pigmented cells continuous with?

A

a) inner limiting membrane of retina
b) basememnt membrane of pigmented epithelium of retina

33
Q

CILIARY EPITHELIUM - non-pigmented layer

Describe structure of non-pigmented cells
(plasma membrane structure + which organelles highest in number)

A

basal and lateral plasma membranes have extensive folds which interdigitate with neighbouring cells

well developed Golgi apparatus, lots of granular and granular endoplasmic reticulum, lots of mitochondria

Appearance = similar to that of cells involved in active transport of water + ions + secretions

34
Q

CILIARY EPITHELIUM - pigmented layer

Describe which organelles present and how abundant they are

Describe structure of plasma membranes

A

LOTS of melanosomes
Scanty, small Golgi apparatus
fair amount of mitochondria

basal plasma membrane - infolding because involved ion transport

35
Q

What is thought to be the role of ciliary epithelium

A

Both layers thought to have involvement in production of aqueous humor

Lots of cell attachment between layers means they are likely coordinated with each other

36
Q

CILIARY STROMA

Describe structure
Does it contain any other structures
Where does connective tissue extend to

A

bundles of loose connective tissue, rich in blood vessels and melanocytes

Contains embedded ciliary muscles

Connective tissue extends to ciliary processes to form connective tissue core

37
Q

CILIARY STROMA

a) Which blood vessels found in stroma?
b) What is found at the peripheral edge of the iris? What is it formed by?
c) describe the structure of the endothelium of the capillaries close to the ciliary epithelium

A

a) ciliary arteries, veins and capillary networks
b) Major arterial arcade - formed by branches of long posterior ciliary arteries
c) fenestrated

38
Q

CILIARY MUSCLE

a) where do most of the muscles attach?
b) which three groups of fibres can the muscle be split into?
c) which type of muscle are they?

A

a) scleral spur
b) Longitudinal/meridional fibres, oblique/radial fibres, circular fibres
c) smooth muscle

39
Q

CILIARY MUSCLE

a) where are the longitudinal/meridional fibres found?
b) where are the oblique/radial fibres found?
c) where are the circular fibres?

A

a) most external, closest to sclera - pass posteriorly into stroma of choroid
b) run from first to third layer of muscles and radiate out from scleral spur
c) most internal, run around eye like sphincter. Lie close to peripheral edge of lens

40
Q

CILIARY MUSCLE

a) what role does contraction of the ciliary muscle play?

A

Contraction of the ciliary muscle (especially longitudinal and ciruclar fibres) pulls ciliary body forward in accommodation.

Forwards movement –> less tension on suspensory ligament => elastic lens becomes more convex and refractive power increases

41
Q

CILIARY MUSCLE

What is the innervation of the ciliary muscle?

A

postganglionic parasympathetic fibres derived from oculomotor nerve

Reach muscle via ciliary nerve

42
Q

IRIS

Name the two margins of the pupil. What does the peripheral one attached to

A

Ciliary margin (peripheral) attached to anterior surface of ciliary body aka root of iris

Pupillary margin

43
Q

IRIS

What is the textbook description of the iris?

A

“thin, contractile, pigmentary diaphragm with central aperture. Suspended in AQ between cornea and lens. Divides space between lens and cornea into posterior and anterior chamber”

44
Q

IRIS

a) diameter
b) where is it thickest (+ how thick)
c) where is it thinnest

A

IRIS

a) 21mm
b) pupillary margin 2mm
c) ciliary margin

45
Q

IRIS

a) size of pupil
b) what percentage of the population have physiologic anisocoria
c) what is responsible for the colour of the iris
d) why do albino people have reddish irises?

A

a) 1mm-8mm
b) 25%
c) presence of pigment in melanocytes. Blue eyes don’t have much pigment => longer wavelengths absorbed, shorter wavelengths (blue) reflected.
d) melanocytes contain NO melanin => Hb in blood vessels of iris and retina give reddish colour

46
Q

IRIS

describe the flow of aqueous humor

A

formed in ciliary processes in posterior chamber, circulates through pupil to anterior chamber and exits into sinus venous sclerae at iris-corneal angle

47
Q

ANTERIOR SURFACE OF IRIS

a) what is the iris divided into?
b) which structure divides it?
c) where is this structure found?
d) describe the anterior surface of the iris
e) what produces the ridges in the ciliary region of the pupil
f) where do the branches of the major arterial circle anastomose? what do they form here?
g) where are the contraction furrows found and what is their purpose
h) what are the iris ruffs?

A

a) pupillary zone and ciliary sone
b) collarette (circular, wavy ridge)
c) 2mm from pupillary margin (NB - iris is thickest here)
d) No epithelium. Radial streaks formed by trabeculae/bands of connective tissue. These enclose Fuch’s crypts (oval shaped crypts that communicate with tissue space of iris)
e) underlying bloods vessels (branches of major arterial circle)
f) at the collarette
g) near outer part of colliery region, fold as pupil dilates
h) radial folds of pigmented posterior epithelium seen at pupillary margin where the epithelium wraps over edge of pupil for short distance

48
Q

IRIS

What is ectropion urea and what can it indicate?

A

when pigmented epithelium of it is extends around pupil margin more extensively than normal.
Indicates possible tumour/other serious pathology causing abnormal traction on iris

49
Q

POSTERIOR IRIS

what colour is the posterior surface of the iris?
Describe the shape its folds

A

black
lots of radial contraction folds, come circular folds at periphery

50
Q

IRIS

Name the two layers of the iris
Where are they derived from embryologically

A

Stroma (anterior) - from mesenchyme
TWO epithelial layers (posterior) - from neural ectoderm

51
Q

STROMA OF IRIS

a) describe the structure of the stroma of the iris (name 8 things it contains)

A

connective tissue, highly vascular. Contains:
- collagen fibres
- fibroblasts
- melanocytes
- matrix
- nerve fibres
- smooth muscle of sphincter pupillae
- myoepithelial cells of dilator papillae

52
Q

STROMA OF IRIS

ANTERIOR SURFACE OF STROMA

a) does it contain epithelium?
b) what three things does it contain?
c) Fuch’s crypts allow communication between the stroma and….?

A

STROMA OF IRIS

ANTERIOR SURFACE OF IRIS

a) NO
b) fibroblasts, melanocytes, collagen fibres
c) anterior chamber

53
Q

STROMA OF IRIS

ANTERIOR SURFACE OF IRIS

a) what is the diameter of the collagen fibrils found here?
b) what is the distance between the collagen fibrils?
c) how are they arranged?
d)what is found in between collagen fibrils on the anterior surface of the iris?
e) are there any elastic fibres here?

A

STROMA OF IRIS

ANTERIOR SURFACE OF IRIS

a) 60nm
b) 50-60nm
c) loosely
d) fluid rich in mucopolysaccharides
e) NO

54
Q

STROMA OF IRIS

ANTERIOR SURFACE OF IRIS

a) describe the shape of the fibroblasts found here
b) what happens to the fibroblasts at the irido-corneal angle
c) describe the shape of the melanocytes
d) do all melanocytes found here contain the same amount of melanosomes

A

STROMA OF IRIS

ANTERIOR SURFACE OF IRIS

a) have numerous branching processes
b) blend in with the fibroblasts found in the TM
c) also have numerous branching dendritic procrsses
d) Nope

55
Q

STROMA OF IRIS

ANTERIOR SURFACE OF IRIS

a) where is the sphincter pupillae muscle found?
b) What kind of muscle is it?
c) how wide is it?
d) what separates the bundle of muscle and what does it contain?
e) how many muscle cells are connected in each bundle of muscle? What connects them?
f) Where do the nerve fibres typically end?
g) what happens when the sphincter pupillae contracts?
h) what is its nerve supply?

A

STROMA OF IRIS

ANTERIOR SURFACE OF IRIS

a) pupillary zone - ring around the pupil
b) smooth muscle
c) 1mm
d) connective tissue containing blood vessels, motor and sensory nerves
e) 6-8 cells connected by GAP JUNCTIONS
f) on one cell at the periphery of each muscle group
g) pupil constricts :p
h) parasympathetic postganglionic fibres of the short ciliary nerves. Derived from oculomotor nerve.

56
Q

What are gap junctions?

A

channels that connect the cytoplasm of adjacent cells, allowing the exchange of ions, small molecules, and second messengers.

57
Q

What are tight junctions?

A

Multi-protein complexes that act as cell-cell adhesion structures in epithelial and endothelial tissues:

Regulate the movement of water, nutrients, and ions across cells, and maintain cell polarity. They also create a barrier that separates the apical and basolateral plasma membrane domains.

58
Q

STROMA OF IRIS

ANTERIOR SURFACE OF IRIS

a) where is the dilator pupillae found?
b) What type of muscle is it?
c) where is it derived from?
d) what shape is the muscle process of this cell? how long and thick are they?
e) where do the nerve fibres supplying the dilator pupillae terminate? Are they myelinated?
f) What happens to the pupil when the dilator pupillae contracts?
g) What is the nerve supply to the dilator pupillae?

A

STROMA OF IRIS

ANTERIOR SURFACE OF IRIS

a) from iris root to sphincter pupillae
b) myoepithelium
c) anterior layer of the iris pigment epithelium that covers the posterior surface of the iris.
NB: whole cell contains myofilaments, but they are more concentrated in the muscular process
d) spindle shaped, 60 microns long and 4 microns thick
e) close to the plasma membrane. NON-myelinated
f) pupil dilates/enlarges :p
g) sympathetic post-ganglionic fibres via long ciliary nerves

59
Q

STROMA OF IRIS

ANTERIOR SURFACE OF IRIS

Where are they sphincter pupillae and dilator pupillae derived from embryologically?

A

STROMA OF IRIS

ANTERIOR SURFACE OF IRIS

  • external layer of optic cup

NB: sphincter acts in bright light and accommodation reflex
dilator acts in dim light + heightened sympathetic activity (eg fear)

60
Q

STROMA OF IRIS

TWO POSTERIOR EPITHELIAL LAYERS OF IRIS

a) where are the two posterior epithelial layers of the iris derived from embryologically?
b) how are the layers apposed to one another?
c) what is found between these two layers?
d) what happens if this is filled?

A

STROMA OF IRIS

TWO POSTERIOR EPITHELIAL LAYERS OF IRIS

a) neuroectoderm of two layers of optic vesicle
b) apex to apex
c) potential space
d) iris cyst forms

61
Q

STROMA OF IRIS

TWO POSTERIOR EPITHELIAL LAYERS OF IRIS

a) what is the anterior epithelial layer in contact with?
b) do the cells of the anterior epithelium contain melanin?
c) what is the anterior layer continuous with?
d) what is the posterior layer in contact with?
e) which are bigger - cells in anterior or posterior layer?
f) do cells of posterior layer contain melanin?
g) what is the posterior layer continuous with?

A

STROMA OF IRIS

TWO POSTERIOR EPITHELIAL LAYERS OF IRIS

a) stroma of iris
b) a few
c) outer pigmented layer of ciliary epithelium
d) aqueous humor
e) posterior layer (cuboidal)
f) yes
g) inner non-pigmented layer of ciliary epithelium

62
Q

STROMA OF IRIS

TWO POSTERIOR EPITHELIAL LAYERS OF IRIS

a) describe the shape of the apical plasma membrane of the epithelial layers
b) what connects the later plasma membranes of adjacent cells of the two posterior epithelial layers together?

A

STROMA OF IRIS

TWO POSTERIOR EPITHELIAL LAYERS OF IRIS

a) microvilli that project into small intercellular spaces
b) tight junctions and desmosomes

63
Q

BLOOD SUPPLY OF IRIS

a) what is the blood supply of the iris?
b) how many vessels supply this?
c) what kind of pattern do the arteries of the iris form? What does this allow for?
d) what vascular structure is found at the collarette?

A

BLOOD SUPPLY OF IRIS

a) radial vessels in the iris stroma derived from major arterial arcade found in ciliary body
b) Two long posterior ciliary arteries and seven anterior ciliary arteries
c) spiral pattern (seen as radial ridges on anterior surface of iris) . Allows for movement of iris when it dilates/constricts
d) minor arterial circle of the iris

64
Q

BLOOD SUPPLY OF IRIS

a) describe the venous drainage of the iris
b) what do they drain into

A

BLOOD SUPPLY OF IRIS

a) follow arteries in forming minor venous circle
DOES NOT DRAIN INTO MAJOR VENOUS CIRCLE, rather drain into vortex veins

65
Q

BLOOD SUPPLY OF IRIS

a) are the blood vessels of the iris fenestrated or non fenestrated?
b) are there tight junctions between the endothelial cells lining the vessels of the iris?
c) what happens when the iris is inflamed as a result of this?

SEE PAGE 154 FOR MORE INFORMATION ON VESSELS

A

Blood supply of iris

a) non-fenestrated
b) nope
c) vessels become leaky - cells and proteins/other large molecules leak into AC.

66
Q

NERVE SUPPLY OF IRIS

a) where does the iris get its sensory and autonomic nerve supply from?
b) what are the long ciliary nerves branches of?
c) where do they get their sympathetic fibres from?
d) where do they get their sensory fibres from?
e) which structures of the long ciliary nerves innervate in the iris?

A

NERVE SUPPLY OF IRIS

a) long and short ciliary nerves
b) branches of nasociliary branch of ophthalmic division of trigeminal nerve
c) superior cervical sympathetic ganglion
d) trigeminal nerve
e) dilator pupillae and blood vessels

67
Q

NERVE SUPPLY OF IRIS

a) where do the short ciliary nerves arise from?
b) what other nerve fibres do they carry (+where from)?
c) Where does the parasympathetic pathway originate?
d) Which structures are innervated by the short ciliary nerves?

A

NERVE SUPPLY OF IRIS

a) ciliary ganglion
b) post-ganglionic parasympathetic nerve fibres + a few sympathetic fibres
c) Edinger Westphal nucleus of oculomotor nerve
d) sphincter pupillae

68
Q

a) what proportion of the light entering the eye is controlled by the iris ( + in log units)

A

1/10th (one log unit)

69
Q

What happens to the choroid with age? (3)

A

atrophy + depigmentation –> patchy appearance of red glow at periphery of Fundus
thickening of Bruch’s membrane, ‘drusen’
blood vessel sclerosis after age of 60

70
Q

What is the most common intraocular tumour and where is it derived from?

A

malignant melanoma
melaonocyte of choroid/ciliary body/iris

71
Q

What is pupillary block glaucoma?

A

When entire pupillary becomes stuck to lens secondary to inflammation (think synechiae but extreme)

72
Q

What percentage of the total ocular blood flow passes through the uveal layer?

A

98%
85% - choroid
7% - ciliary body
5% - iris

73
Q
A